公开(公告)号：US20150357174A1

公开(公告)日：2015-12-10

申请号：US14733517

申请日：2015-06-08

Applicant: Yehia M. Ibrahim ,  Tsung-Chi Chen ,  Marques B. Harrer ,  Keqi Tang ,  Richard D. Smith

Inventor： Yehia M. Ibrahim ,  Tsung-Chi Chen ,  Marques B. Harrer ,  Keqi Tang ,  Richard D. Smith

IPC: H01J49/06

CPC classification number: H01J49/066

Abstract: An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.

Abstract translation: 公开了一种离子漏斗装置。 第一对电极位于第一方向。 第二对电极位于第二方向。 该器件包括一个RF电压源和一个直流电压源。 将具有叠加的DC电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。

公开(公告)号：US20130299690A1

公开(公告)日：2013-11-14

申请号：US13861511

申请日：2013-04-12

Applicant: Alexandre A. Shvartsburg ,  Keqi Tang ,  Richard D. Smith

Inventor： Alexandre A. Shvartsburg ,  Keqi Tang ,  Richard D. Smith

IPC: H01J49/00

CPC classification number: H01J49/0031 ,  G01N27/622

Abstract: A method for raising the resolving power, specificity, and peak capacity of conventional ion mobility spectrometry is disclosed. Ions are separated in a dynamic electric field comprising an oscillatory field wave and opposing static field, or at least two counter propagating waves with different parameters (amplitude, profile, frequency, or speed). As the functional dependencies of mean drift velocity on the ion mobility in a wave and static field or in unequal waves differ, only single species is equilibrated while others drift in either direction and are mobility-separated. An ion mobility spectrum over a limited range is then acquired by measuring ion drift times through a fixed distance inside the gas-filled enclosure. The resolving power in the vicinity of equilibrium mobility substantially exceeds that for known traveling-wave or drift-tube IMS separations, with spectra over wider ranges obtainable by stitching multiple segments. The approach also enables low-cutoff, high-cutoff, and bandpass ion mobility filters.

Abstract translation: 公开了提高常规离子迁移光谱法的分辨能力，特异性和峰值能力的方法。 离子在包括振荡场波和相对静电场的动态电场中分离，或至少两个具有不同参数（幅度，分布，频率或速度）的反向传播波。 由于平均漂移速度对波和静电场或不相等波的离子迁移率的功能依赖性不同，只有单个物质平衡，而其他物质在任一方向上漂移并且是迁移率分离的。 然后通过在充满气体的外壳内的固定距离测量离子漂移时间来获得在有限范围内的离子迁移谱。 在平衡迁移附近的分辨能力基本上超过已知的行波或漂移管IMS分离的分辨能力，其中可以通过缝合多个段获得更宽范围的光谱。 该方法还可实现低截止，高截止和带通离子迁移率滤波器。

公开(公告)号：US08454093B2

公开(公告)日：2013-06-04

申请号：US12748823

申请日：2010-03-29

Applicant: Richard D. Smith

Inventor： Richard D. Smith

IPC: A47C7/00

CPC classification number: A47C3/04 ,  A47C4/28 ,  A47C4/48 ,  A47C7/282

Abstract: A folding or stacking chair has a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. One or both of the seat and the backrest has a continuous sheet of flexible and elastic knitted mesh or patterned open texture plastic held across and substantially covering an opening in an open-end hoop coupled between the frame sides. An open-end of the hoop faces in a front or a back orientation for the seat, or a top or a bottom orientation for the backrest, with sides of the hoop attached to the frame sides. The sheet of mesh or textured plastic has a finished edge spanning the open-end of the hoop.

Abstract translation: 折叠或折叠椅子具有座椅和靠背，其在相对的框架侧面之间承载，每个座椅具有靠背支撑件，前腿部和后腿部。 座椅和靠背中的一个或两个具有柔性和弹性的针织网或图案化的开放纹理塑料的连续片，该织物保持横跨并且基本上覆盖耦合在框架侧之间的开口箍中的开口。 箍的开口端面朝向座椅的前方或后方，或用于靠背的顶部或底部方向，箍的侧面连接到框架侧。 网状或纹理化的塑料片具有跨越箍的开口端的成品边缘。

公开(公告)号：US08038221B2

公开(公告)日：2011-10-18

申请号：US12422821

申请日：2009-04-13

Applicant: Richard D. Smith ,  Orrin C. Farnsworth

Inventor： Richard D. Smith ,  Orrin C. Farnsworth

IPC: A47C7/00

CPC classification number: A47C4/44 ,  A47C3/04 ,  A47C4/28 ,  A47C4/38 ,  A47C5/06 ,  A47C7/002 ,  A47C7/282

Abstract: A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides. The hoop includes inner and outer plastic mating hoops with the mesh extending over an outer perimeter of the inner hoop and into an interface between the inner and outer hoops.

Abstract translation: 折叠网椅包括座位和靠在相对的框架侧之间的靠背。 椅子具有展开的就座位置，其中座椅从框架侧面枢转并从前腿和后腿的底部移开，折叠位置，座位朝向框架侧摆动，前后腿一起移动。 座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。 箍包括内部和外部塑料配合箍，其中网状物在内箍的外周延伸并且进入内圈和外箍之间的界面。

公开(公告)号：US20100207022A1

公开(公告)日：2010-08-19

申请号：US12690818

申请日：2010-01-20

Applicant: Keqi Tang ,  Alexandre A. Shvartsburg ,  Richard D. Smith

Inventor： Keqi Tang ,  Alexandre A. Shvartsburg ,  Richard D. Smith

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/02

CPC classification number: G01N27/624

Abstract: A differential ion mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) platform is disclosed that utilizes both gas flow and electric field, consecutively or simultaneously, to move ions through the analytical gap. The consecutive combination of flow and field enables rapid and flexible switching of the FAIMS stage “on” (for ion separation) and “off” (for high non-selective transmission) with no hardware modifications. This capability is needed for effective use of multidimensional instrument systems that couple FAIMS to mass spectrometry and/or conventional ion mobility spectrometry. The joint application of flow and field allows controlling the discrimination against high-mobility ions, maximizing it to remove the chemical noise or minimizing it to make the analyses of complex samples more predictable and uniform.

Abstract translation: 公开了差分离子迁移谱或场非对称波形离子迁移谱（FAIMS）平台，其利用气流和电场连续或同时地将离子移动通过分析间隙。 流程和现场的连续组合使得无需硬件修改即可快速灵活地切换FAIMS阶段（离子分离）和“关闭”（用于高非选择性传输）。 需要这种能力来有效利用将FAIMS耦合到质谱和/或常规离子迁移谱的多维仪器系统。 流量和场的联合应用允许控制对高迁移率离子的鉴别，使其最大化以消除化学噪声或使其最小化，使得复杂样品的分析更可预测和均匀。

公开(公告)号：US20100156148A1

公开(公告)日：2010-06-24

申请号：US12422792

申请日：2009-04-13

Applicant: Richard D. Smith ,  Orrin C. Farnsworth

Inventor： Richard D. Smith ,  Orrin C. Farnsworth

IPC: A47C4/28

CPC classification number: A47C4/44 ,  A47C3/04 ,  A47C4/28 ,  A47C4/38 ,  A47C5/06 ,  A47C7/002 ,  A47C7/282

Abstract: A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides.

Abstract translation: 折叠网椅包括座位和靠在相对的框架侧之间的靠背。 椅子具有展开的就座位置，其中座椅枢转以从框架侧面延伸，前后腿的底部移动分开，并且座椅朝向框架侧部枢转并且前后腿部一起移动的折叠位置。 座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。

公开(公告)号：US20090117578A1

公开(公告)日：2009-05-07

申请号：US12291173

申请日：2008-11-05

Applicant: Thomas O. Metz ,  Weijun Qian ,  Jon M. Jacobs ,  David G. Camp, II ,  Richard D. Smith

Inventor： Thomas O. Metz ,  Weijun Qian ,  Jon M. Jacobs ,  David G. Camp, II ,  Richard D. Smith

IPC: C12Q1/68

CPC classification number: G01N33/6893 ,  G01N2333/4728 ,  G01N2333/723 ,  G01N2333/775 ,  G01N2333/79 ,  G01N2800/042 ,  G01N2800/50

Abstract: A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.

Abstract translation: 一种利用I型糖尿病预测和诊断生物标志物分类受试者群体的方法和系统。 该方法包括确定目标生物体的血清或血浆内的各种标志物的水平，并将该水平与一般群体相关联作为疾病存在或倾向性的倾向或逐步监测的屏幕。

公开(公告)号：US20090108194A1

公开(公告)日：2009-04-30

申请号：US11251529

申请日：2005-09-30

Applicant: Jason S. Page ,  Keqi Tang ,  Richard D. Smith

Inventor： Jason S. Page ,  Keqi Tang ,  Richard D. Smith

IPC: B01D59/44

CPC classification number: H01J49/066 ,  G01N27/622

Abstract: An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution.

Abstract translation: 公开了一种可调节的低质量 - 电荷（m / z）滤波器，其使用电喷雾电离来阻挡与不想要的低m / z物质相关的离子进入质谱仪并且为下游离子累积步骤贡献其空间电荷。 低质量过滤器通过使用来自电动离子漏斗的电导限制端子电极的可调势势垒来制造，其阻止具有较高离子迁移率的物质被传输。 滤波器提供从大约50到大约500的m / z值的低质量滤波的线性电压调节。也可以执行m / z 500以上的质量过滤; 然而，更高的m / z物种减弱。 通过对白蛋白胰蛋白酶消化物的液相色谱 - 质谱分析来评估质量过滤器，并且导致阻断低质量“背景”离子的能力，其占离子源的总离子电流的40-70％ 峰洗脱。

公开(公告)号：US07499807B1

公开(公告)日：2009-03-03

申请号：US11524028

申请日：2006-09-19

Applicant: Aleksey V. Tolmachev ,  Richard D. Smith

Inventor： Aleksey V. Tolmachev ,  Richard D. Smith

IPC: G06F3/00

CPC classification number: H01J49/0009

Abstract: Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.

Abstract translation: 公开了重新校准质谱数据的方法，其通过调整对质量测量精度具有实质性影响的参数的实验方差来提高质量精度和精度。 使用通过匹配集合的测量和推定质量值编译的相关质量值对来确定最优系数，从而使总体有效质量误差和质量误差扩展最小化。 随后使用系数来校正在测量数据集中检测到的峰的质量值，从而提供其重新校准。 在重新校准后，在复杂的真菌蛋白质组上已经证明了亚ppm质量测量精度，为肽鉴定提供了改进的置信度。

公开(公告)号：US07148474B2

公开(公告)日：2006-12-12

申请号：US11103984

申请日：2005-04-11

Applicant: Keqi Tang ,  Alexandre A. Shvartsburg ,  Richard D. Smith

Inventor： Keqi Tang ,  Alexandre A. Shvartsburg ,  Richard D. Smith

IPC: H01J49/40 ,  H01J49/26 ,  B01D59/44

CPC classification number: G01N27/624 ,  H01J49/004

Abstract: The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.

Abstract translation: 本发明涉及气相离子的分离和表征装置。 该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。 在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。 另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。 本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。