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1.发明授权公开(公告)号：US08722938B2
公开(公告)日：2014-05-13
申请号：US13504167
申请日：2010-11-18
Applicant: Raphael Mechoulam , Lital Magid , Esther Shohami , Itai Bab
Inventor： Raphael Mechoulam , Lital Magid , Esther Shohami , Itai Bab
CPC classification number: C07D311/94 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/70 , C07C51/00 , C07C51/09 , C07C69/757 , C07C2602/42 , C07D311/80 , C07D311/96 , C07C49/753 , C07C62/24 , C07C62/34
Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
Abstract translation: 本发明涉及芳基化的Camphenes，其制备方法及其用途，用于制备用于治疗与CB2受体相关或有利于CB2受体的疾病，病症或病症的药物。
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2.发明申请NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF 有权新的ARYLATED CAMPHENES，其制备方法及其用途
公开(公告)号：US20120245366A1
公开(公告)日：2012-09-27
申请号：US13504167
申请日：2010-11-18
Applicant: Raphael Mechoulam , Lital Magid , Esther Shohami , Itai Bab
Inventor： Raphael Mechoulam , Lital Magid , Esther Shohami , Itai Bab
IPC: C07C43/215 , C07C43/23 , C07C62/34 , C07D311/94 , C07C67/31 , C07C41/30 , C07C51/367 , C07C45/64 , C07C69/757 , C07C49/753
CPC classification number: C07D311/94 , C07C39/23 , C07C43/215 , C07C43/23 , C07C45/70 , C07C51/00 , C07C51/09 , C07C69/757 , C07C2602/42 , C07D311/80 , C07D311/96 , C07C49/753 , C07C62/24 , C07C62/34
Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
Abstract translation: 本发明涉及芳基化的Camphenes，其制备方法及其用途，用于制备用于治疗与CB2受体相关或有利于CB2受体的疾病，病症或病症的药物。
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3.发明申请
公开(公告)号：US20100222438A1
公开(公告)日：2010-09-02
申请号：US12710540
申请日：2010-02-23
Applicant: Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
Inventor： Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
IPC: A61K31/085 , A61P19/00 , C12Q1/02 , C12Q1/68
CPC classification number: A61K38/1875 , A61K31/00 , A61K31/232 , A61K31/353 , A61K31/454 , A61K31/663 , A61K38/1825 , A61K38/27 , A61K38/29 , A61K38/553 , A61K45/06 , G01N33/566 , A61K2300/00
Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.
Abstract translation: 公开了适用于调节骨生长和重塑，预防骨骼疾病，诱导骨生长或通过大麻素受体介导的对骨细胞的影响的修复的新型方法和药物组合物。 还公开了鉴定骨生长调节剂的方法。
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4.发明申请Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis 失效用于诊断，延缓发病，预防和/或治疗骨质疏松症的方法，试剂盒和药物组合物
公开(公告)号：US20050260608A1
公开(公告)日：2005-11-24
申请号：US10851667
申请日：2004-05-24
Applicant: Andreas Zimmer , Meliha Karsak , Marie-Christine De Vernejoul , Itai Bab , Esther Shohami , Raphael Mechoulam
Inventor： Andreas Zimmer , Meliha Karsak , Marie-Christine De Vernejoul , Itai Bab , Esther Shohami , Raphael Mechoulam
CPC classification number: C07K16/18 , C12Q1/6886 , C12Q2600/16 , C12Q2600/172
Abstract: The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.
Abstract translation: 本发明揭示了编码大麻素受体2蛋白的CNR2基因座中的SNP与骨质疏松症的高度显着的关联。 提供了确定骨质疏松症倾向的方法和试剂盒，改善疑似患有骨质疏松症的个体的诊断。 还提供了鉴定受试者中推定的引起骨质疏松症的遗传突变的方法。
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5.发明授权
公开(公告)号：US07749953B2
公开(公告)日：2010-07-06
申请号：US11003939
申请日：2004-12-06
Applicant: Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
Inventor： Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
CPC classification number: A61K38/1875 , A61K31/00 , A61K31/232 , A61K31/353 , A61K31/454 , A61K31/663 , A61K38/1825 , A61K38/27 , A61K38/29 , A61K38/553 , A61K45/06 , G01N33/566 , A61K2300/00
Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.
Abstract translation: 公开了适用于调节骨生长和重塑，预防骨骼疾病，诱导骨生长或通过大麻素受体介导的对骨细胞的影响的修复的新型方法和药物组合物。 还公开了鉴定骨生长调节剂的方法。
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6.发明授权Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis 失效用于诊断，延缓发病，预防和/或治疗骨质疏松症的方法，试剂盒和药物组合物
公开(公告)号：US07407753B2
公开(公告)日：2008-08-05
申请号：US10851667
申请日：2004-05-24
Applicant: Andreas Zimmer , Meliha Karsak , Marie-Christine De Vernejoul , Itai Bab , Esther Shohami , Raphael Mechoulam
Inventor： Andreas Zimmer , Meliha Karsak , Marie-Christine De Vernejoul , Itai Bab , Esther Shohami , Raphael Mechoulam
CPC classification number: C07K16/18 , C12Q1/6886 , C12Q2600/16 , C12Q2600/172
Abstract: The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.
Abstract translation: 本发明揭示了编码大麻素受体2蛋白的CNR2基因座中的SNP与骨质疏松症的高度显着的关联。 提供了确定骨质疏松症倾向的方法和试剂盒，改善疑似患有骨质疏松症的个体的诊断。 还提供了鉴定受试者中推定的引起骨质疏松症的遗传突变的方法。
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7.发明申请
公开(公告)号：US20050137159A1
公开(公告)日：2005-06-23
申请号：US11003939
申请日：2004-12-06
Applicant: Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
Inventor： Itai Bab , Raphael Mechoulam , Andreas Zimmer , Esther Shohami
IPC: A61K31/00 , A61K31/232 , A61K31/353 , A61K31/454 , A61K31/663 , A61K38/18 , A61K38/27 , A61K38/29 , A61K38/55 , A61K45/06 , A61K48/00 , C07K14/72 , G01N33/566
CPC classification number: A61K38/1875 , A61K31/00 , A61K31/232 , A61K31/353 , A61K31/454 , A61K31/663 , A61K38/1825 , A61K38/27 , A61K38/29 , A61K38/553 , A61K45/06 , G01N33/566 , A61K2300/00
Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.
Abstract translation: 公开了适用于调节骨生长和重塑，预防骨骼疾病，诱导骨生长或通过大麻素受体介导的对骨细胞的影响的修复的新型方法和药物组合物。 还公开了鉴定骨生长调节剂的方法。
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公开(公告)号：US20110046222A1
公开(公告)日：2011-02-24
申请号：US12936498
申请日：2009-04-07
Applicant: Raphael Mechoulam , Itai Bab , Gary Milman , Reem Smoum
Inventor： Raphael Mechoulam , Itai Bab , Gary Milman , Reem Smoum
IPC: A61K31/20 , C07C229/30 , A61P19/08
CPC classification number: C07C233/49
Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.
Abstract translation: 提供氨基酸的脂肪酸酰胺，其用途和包括它们的药物组合物。
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公开(公告)号：US08198327B2
公开(公告)日：2012-06-12
申请号：US12936498
申请日：2009-04-07
Applicant: Raphael Mechoulam , Itai Bab , Gary Milman , Reem Smoum
Inventor： Raphael Mechoulam , Itai Bab , Gary Milman , Reem Smoum
IPC: A61K31/20
CPC classification number: C07C233/49
Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.
Abstract translation: 提供氨基酸的脂肪酸酰胺，其用途和包括它们的药物组合物。
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10.发明授权Compositions comprising CB receptor agonists, uses thereof and methods for their preparation 有权包含CB受体激动剂的组合物，其用途及其制备方法
公开(公告)号：US09428431B2
公开(公告)日：2016-08-30
申请号：US13122662
申请日：2009-10-11
Applicant: Itai Bab , Raphael Mechoulam , Aviva Breuer , Naama Mussai
Inventor： Itai Bab , Raphael Mechoulam , Aviva Breuer , Naama Mussai
IPC: C07C43/23 , C07C67/14 , C07C67/29 , C07C67/293 , C07C41/26
CPC classification number: C07C43/23 , C07B2200/07 , C07C41/26 , C07C67/14 , C07C67/29 , C07C67/293 , C07C2601/16 , C07C2602/42 , C07C69/24 , C07C69/14
Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
Abstract translation: 提供了包含具有CB受体激动剂性质的苯基取代的蒎烯的（3R，4R，6R） - 立体异构体的组合物，以及用该药物组合物治疗疾病或病症的方法及其制备方法。
