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公开(公告)号：US20190137931A1
公开(公告)日：2019-05-09
申请号：US16239297
申请日：2019-01-03
Applicant: Premium Genetics (UK) LTD
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G03H1/00 , G01N21/64 , G01N33/50 , B01L3/00 , B01D21/01 , B01D21/26 , B03C1/00 , A61L2/08 , G01N27/447 , G21K5/08 , G02B21/32 , H05H3/04 , G01N33/487 , B04B13/00
Abstract: The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage,
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公开(公告)号：US10216144B2
公开(公告)日：2019-02-26
申请号：US15099891
申请日：2016-04-15
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G03H1/00 , G02B21/32 , H05H3/04 , B01D21/01 , G01N33/487 , G01N21/64 , G01N33/50 , A61L2/08 , B01D21/26 , B03C1/00 , B04B13/00 , G01N27/447 , G21K5/08 , B01L3/00 , G03H1/08 , G03H1/22 , B03C1/28 , B03C5/00 , G01N15/00 , G01N15/02 , B01D21/00
Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
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公开(公告)号：US09000357B2
公开(公告)日：2015-04-07
申请号：US14317738
申请日：2014-06-27
Applicant: Premium Genetics (UK) Ltd.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture.
Abstract translation: 一种用于从流体混合物中的多个组分中鉴定至少一种组分的装置和方法，包括含有组分的流体混合物的第一输入通道; 至少一个缓冲器输入通道，其中引入至少一个额外的缓冲溶液流; 设置在所述装置的另一端的多个区域，所述多个区域适于接收所述多个部件中的至少一个选定部件的输出，所述选择部件被选择性地从所述第一流程移除到所述区域之一; 废物通道，从第一流中除去未选择的组分; 连接到至少一个储存器的多个泵，以控制第一流量和附加流量的流量; 以及计算机，其从所述流体混合物控制所述多个部件之一的选择。
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4.发明申请MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING 审中-公开多层次流动粒子和细胞分离与激光转向公开(公告)号：US20160299469A1
公开(公告)日：2016-10-13
申请号：US15099891
申请日：2016-04-15
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G03H1/00 , G01N33/50 , G21K5/08 , G01N33/487
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
Abstract translation: 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。
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公开(公告)号：US20160299120A1
公开(公告)日：2016-10-13
申请号：US15099900
申请日：2016-04-15
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G01N33/487 , H05H3/04 , G03H1/00 , G01N21/64 , G02B21/32
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
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Patent Agency Ranking
公开(公告)号：US09140690B2
公开(公告)日：2015-09-22
申请号：US14663012
申请日：2015-03-19
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G01N33/50 , G02B21/32 , H05H3/04 , B01D21/01 , G01N33/487 , G01N21/64 , G03H1/08 , G03H1/22 , G03H1/00
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: A method of identifying at least one component from a plurality of components in a fluid mixture introduced into a flow apparatus, includes: introducing a first flow into a first input channel in the apparatus which contains the fluid mixture; introducing additional flows of buffer solution into a plurality of buffer input channels in the apparatus, the plurality of buffer channels which are disposed on either side of the first input channel; wherein the first flow and additional flows have a flow direction along a length of the apparatus; identifying selected components of the plurality of components using a detector apparatus; emitting a light beam from a laser which damages or kills selected components of the plurality of components; receiving the first flow and the additional flows in at least one channel disposed at the other end of the apparatus, after operation of the light beam on the selected components.
Abstract translation: 一种从引入到流动装置中的流体混合物中的多个部件中鉴定至少一个部件的方法，包括：将第一流引入到包含流体混合物的装置中的第一输入通道中; 将附加的缓冲溶液流引入所述装置中的多个缓冲器输入通道中，所述多个缓冲通道设置在所述第一输入通道的任一侧上; 其中所述第一流和附加流具有沿所述装置的长度的流动方向; 使用检测器装置识别所述多个部件中的选定部件; 发射来自激光器的光束，其损坏或杀死所述多个部件中的所选部件; 在所选择的部件上操作光束之后，在设置在设备的另一端的至少一个通道中接收第一流和附加流。
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公开(公告)号：US09335295B2
公开(公告)日：2016-05-10
申请号：US14829993
申请日：2015-08-19
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G01N27/447 , G01N33/487 , B03C1/00 , B01D21/26 , B04B13/00 , A61L2/08
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
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公开(公告)号：USRE46992E1
公开(公告)日：2018-08-14
申请号：US15284238
申请日：2016-10-03
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Amy L. Morjal , Christopher R. Knutson , Joseph Plewa
CPC classification number: G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
Abstract: Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.
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公开(公告)号：US09977401B2
公开(公告)日：2018-05-22
申请号：US15099900
申请日：2016-04-15
Applicant: PREMIUM GENETICS (UK) LTD.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC: G03H1/00 , G02B21/32 , H05H3/04 , B01D21/01 , G01N33/487 , G01N21/64 , G01N33/50 , A61L2/08 , B01D21/26 , B03C1/00 , B04B13/00 , G01N27/447 , G21K5/08 , G03H1/08 , G03H1/22 , B03C1/28 , B03C5/00 , G01N15/00 , G01N15/02
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
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公开(公告)号：US08933395B2
公开(公告)日：2015-01-13
申请号：US14169927
申请日：2014-01-31
Applicant: Premium Genetics (UK) Ltd.
Inventor： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
CPC classification number: G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
Abstract: The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components.
Abstract translation: 本发明提供了一种从流体混合物中的多个组分中鉴定至少一种组分的方法和装置，该装置包括：第一输入通道，其中引入包含多个组分的第一流; 设置在第一输入通道的任一侧的多个缓冲器输入通道，其中引入了附加的缓冲溶液流; 其中所述第一流和所述附加流具有沿所述装置的长度的流动方向; 检测装置，其检测并识别所述多个部件的选定部件; 发射激光束的激光器，其损坏或杀死所述多个部件的选定部件; 以及设置在设备的另一端的至少一个通道，其适于在所选择的部件上操作激光器之后接收第一流量和附加流量。
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