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1.发明申请公开(公告)号：US20210085762A1
公开(公告)日：2021-03-25
申请号：US16943933
申请日：2020-07-30
Applicant: Portola Pharmaceuticals, Inc.
Inventor： Uma Sinha , Genmin Lu , Athiwat Hutchaleelaha , Stanley J. Hollenbach
Abstract: The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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2.发明授权
公开(公告)号：US10765726B2
公开(公告)日：2020-09-08
申请号：US15833520
申请日：2017-12-06
Applicant: Portola Pharmaceuticals, Inc.
Inventor： Uma Sinha , Genmin Lu , Athiwat Hutchaleelaha , Stanley J. Hollenbach
Abstract: The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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3.发明申请
公开(公告)号：US20180236049A1
公开(公告)日：2018-08-23
申请号：US15833520
申请日：2017-12-06
Applicant: Portola Pharmaceuticals, Inc.
Inventor： Uma Sinha , Genmin Lu , Athiwat Hutchaleelaha , Stanley J. Hollenbach
Abstract: The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
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4.发明申请
公开(公告)号：US20180185459A1
公开(公告)日：2018-07-05
申请号：US15902886
申请日：2018-02-22
Applicant: Portola Pharmaceuticals, Inc.
Inventor： Stanley J. Hollenbach , Genmin Lu , Uma Sinha
CPC classification number: A61K38/4846 , C12N9/6432 , C12Y304/21006
Abstract: The present disclosure provides unit dose formulations and methods to reduce, stop or prevent bleeding in a patient undergoing anticoagulant therapy with a factor Xa inhibitor. The methods entail at least partial neutralization of the factor Xa inhibitors The unit dose formulations and methods of the present disclosure can be effective even after actual bleeding has initiated.
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5.发明申请UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME 审中-公开单元剂量制剂对于XA抑制因子的抗体及其使用方法
公开(公告)号：US20170014492A1
公开(公告)日：2017-01-19
申请号：US15212105
申请日：2016-07-15
Applicant: Portola Pharmaceuticals, Inc.
Inventor： Uma Sinha , Genmin Lu , Athiwat Hutchaleelaha , Stanley J. Hollenbach
CPC classification number: A61K38/4846 , A61K9/0019 , C12N9/6432 , C12Y304/21006
Abstract: The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Abstract translation: 本发明涉及解毒剂的单位剂量制剂与靶向因子Xa的抗凝剂。 本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。
