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公开(公告)号：US20150315182A1
公开(公告)日：2015-11-05
申请号：US14443911
申请日：2013-11-21
Applicant: PTC THERAPEUTICS, INC.
Inventor： Chang-Sun Lee , Ramil Baiazitov , Liangxian Cao , Thomas W Davis , Wu Du , Ronggang Liu , Young-choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D471/04 , A61N5/10 , C07D403/04 , C07D487/04 , A61K31/506 , A61K45/06
CPC classification number: C07D403/12 , A61K31/506 , A61K45/06 , A61N5/10 , C07D403/04 , C07D471/04 , C07D487/04 , Y02A50/411
Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
Abstract translation: 胺取代的反向嘧啶化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平降低，以及用于抑制Bmi-1功能并降低其水平的方法 本文描述了用于治疗由Bmi-1介导的癌症的Bmi-1。
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公开(公告)号：US11180483B2
公开(公告)日：2021-11-23
申请号：US16583442
申请日：2019-09-26
Applicant: PTC Therapeutics, Inc.
Inventor： Chang-Sun Lee , Ramil Baiazitov , Liangxian Cao , Thomas W. Davis , Wu Du , Ronggang Liu , Young-Choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: A61K31/506 , A61K45/06 , A61N5/10 , C07D403/04 , C07D471/04 , C07D487/04 , C07D403/12
Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
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公开(公告)号：US10584115B2
公开(公告)日：2020-03-10
申请号：US15037514
申请日：2013-11-21
Applicant: PTC Therapeutics, Inc.
Inventor： Ramil Baiazitov , Soongyu Choi , Wu Du , Seongwoo Hwang , Chang-Sun Lee , Ronggang Liu , Young-Choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D403/04 , C07D401/14 , C07F5/04 , A61K31/69 , C07D471/04 , A61K31/519 , C07D405/14 , C07D417/14 , C07D401/04 , A61K31/4985 , C07D413/04 , C07D403/14 , A61K45/06 , C07D487/04 , A61K31/497 , C07D513/04
Abstract: Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
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公开(公告)号：US20160280685A1
公开(公告)日：2016-09-29
申请号：US15037514
申请日：2013-11-21
Applicant: PTC THERAPEUTICS, INC
Inventor： Ramil Baiazitov , Soongyu Choi , Wu Du , Seongwoo Hwang , Chang-Sun Lee , Ronggang Liu , Young-Choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D403/04 , C07D401/14 , C07F5/04 , A61K31/69 , C07D471/04 , A61K31/519 , C07D405/14 , C07D417/14 , C07D401/04 , A61K31/4985 , C07D413/04 , C07D403/14 , A61K45/06 , C07D487/04 , A61K31/497
Abstract: Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
Abstract translation: 胺取代的吡啶和吡嗪化合物及其形式，其抑制B细胞特异性莫洛尼鼠白血病病毒整合位点1（Bmi-1）蛋白的功能和水平降低，以及它们用于抑制Bmi-1功能和降低水平的方法 的Bmi-1治疗由Bmi-1介导的癌症。
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公开(公告)号：US20220064150A1
公开(公告)日：2022-03-03
申请号：US17523480
申请日：2021-11-10
Applicant: PTC Therapeutics, Inc.
Inventor： Chang-Sun Lee , Ramil Baiazitov , Liangxian Cao , Thomas W. Davis , Wu Du , Ronggang Liu , Young-Choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D403/12 , A61K31/506 , A61K45/06 , C07D487/04 , A61N5/10 , C07D403/04 , C07D471/04
Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
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公开(公告)号：US20200024260A1
公开(公告)日：2020-01-23
申请号：US16583442
申请日：2019-09-26
Applicant: PTC Therapeutics, Inc.
Inventor： Chang-Sun Lee , Ramil Baiazitov , Liangxian Cao , Thomas W. Davis , Wu Du , Ronggang Liu , Young-Choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D403/12 , A61K31/506 , A61K45/06 , C07D487/04 , A61N5/10 , C07D403/04 , C07D471/04
Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
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公开(公告)号：US10428050B2
公开(公告)日：2019-10-01
申请号：US14443911
申请日：2013-11-21
Applicant: PTC Therapeutics, Inc.
Inventor： Chang-Sun Lee , Ramil Baiazitov , Liangxian Cao , Thomas W Davis , Wu Du , Ronggang Liu , Young-choon Moon , Steven D. Paget , Hongyu Ren , Nadiya Sydorenko , Richard Gerald Wilde
IPC: C07D471/04 , C07D403/04 , C07D487/04 , A61K31/506 , A61K45/06 , A61N5/10 , C07D403/12
Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.
