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    METHODS AND COMPOSITIONS FOR IMPROVING DETECTION AND/OR CAPTURE OF A TARGET ENTITY
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR IMPROVING DETECTION AND/OR CAPTURE OF A TARGET ENTITY 审中-公开
    用于改善目标实体的检测和/或捕获的方法和组合物

    公开(公告)号：US20150377881A1

    公开(公告)日：2015-12-31

    申请号：US14766575

    申请日：2014-03-14

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Michael SUPER ,  Mark J. CARTWRIGHT ,  Martin M. ROTTMAN ,  Julie A. TOMOLONIS

    IPC: G01N33/569

    CPC classification number: G01N33/569 ,  G01N33/5306 ,  G01N33/54393 ,  G01N2400/00 ,  G01N2469/10

    Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample. In particular, the methods, compositions and kits described herein relate to pretreatment of target-binding agents with a blocking agent described herein to reduce non-target binding in a complex matrix (e.g., blood). In some embodiments, methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also provided herein.

    Abstract translation: 本文描述的各个方面的实施例涉及用于检测和/或捕获样品中的目标实体的方法，组合物，试剂盒和系统。 特别地，本文所述的方法，组合物和试剂盒涉及用本文所述的封闭剂预处理靶结合剂以减少复合基质（例如血液）中的非靶结合。 在一些实施方案中，本文还提供了用于在测试样品中检测和/或捕获微生物的方法和组合物，包括体液如受试者的血液和组织，食物，水和环境表面。

    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
    8.
    发明申请
    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 审中-公开

    公开(公告)号：US20200239552A1

    公开(公告)日：2020-07-30

    申请号：US16683630

    申请日：2019-11-14

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Donald E. INGBER ,  Michael SUPER ,  Jeffrey Charles WAY ,  Mark J. CARTWRIGHT ,  Julia B. BERTHET ,  Dinah R. SUPER ,  Martin ROTTMAN ,  Alexander L. WATTERS

    IPC: C07K16/12 ,  A61K47/68 ,  G01N33/543 ,  G01N33/569 ,  C07K14/42

    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
    9.
    发明申请
    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 有权

    公开(公告)号：US20210155677A1

    公开(公告)日：2021-05-27

    申请号：US17093781

    申请日：2020-11-10

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Donald E. INGBER ,  Michael SUPER ,  Jeffrey Charles WAY ,  Mark J. CARTWRIGHT ,  Julia B. BERTHET ,  Dinah R. SUPER ,  Martin ROTTMAN ,  Alexander L. WATTERS

    IPC: C07K16/12 ,  A61K47/68 ,  G01N33/543 ,  G01N33/569 ,  C07K14/42

    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

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