公开(公告)号：US20160264579A1

公开(公告)日：2016-09-15

申请号：US15034905

申请日：2014-11-06

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Takayuki INUKAI ,  Jun TAKEUCHI ,  Tomoko YASUHIRO ,  Mark Allan WOLF ,  Vijay Dattaram PAWAR ,  Anjan CHAKRABARTI ,  Santhosh Kumar CHITTIMALLA

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A compound represented by the general formula (1) has a pyridone ring structure introduced into a pyrrolo pyrimidine skeleton, so that the compound has a strong Axl inhibitory activity. Consequently, the compound can be used as a therapeutic agent for Axl-related diseases including cancers such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.

Abstract translation: 由通式（1）表示的化合物具有引入吡咯并嘧啶骨架的吡啶酮环结构，使得该化合物具有强的Axl抑制活性。 因此，该化合物可以用作Axl相关疾病的治疗剂，包括急性骨髓性白血病，黑素瘤，乳腺癌，胰腺癌，神经胶质瘤，肾脏疾病，免疫系统疾病和循环系统疾病等癌症。

公开(公告)号：US20170327439A1

公开(公告)日：2017-11-16

申请号：US15532389

申请日：2014-12-03

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Kensuke KUSUMI ,  Haruto KURATA ,  Atsushi NAGANAWA ,  Yasuyo KODERA ,  Yuichi INAGAKI ,  Hiroya TAKIZAWA ,  Mark Allan WOLF ,  Joseph RAKER

IPC: C07C13/48 ,  C07D205/04 ,  A61K31/397 ,  A61K31/19 ,  A61K31/015 ,  C07D401/10 ,  C07C13/20 ,  C07C2602/10

CPC classification number: C07C13/48 ,  A61K31/015 ,  A61K31/19 ,  A61K31/397 ,  C07C13/20 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/16 ,  C07D401/10 ,  C07D403/10

Abstract: A compound represented by general formula (I) (wherein, all the symbols are as defined in the specification) has a selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skeleton; .i.e., due to having a short linker of one atom or less as L in general formula (I), and can therefore serve as an agent for treating S1P5-mediated disease, e.g., neurodegenerative disease such as schizophrenia.