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公开(公告)号：US12139471B2
公开(公告)日：2024-11-12
申请号：US17574820
申请日：2022-01-13
Applicant: Novartis AG
Inventor： Christopher Farady , Nina Gommermann , Philipp Janser , Angela Mackay , Henri Mattes , Nichola Smith , Catherine Fooks Solovay , Nikolaus Johannes Stiefl , Eric Vangrevelinghe , Juraj Velcicky , Anette von Matt
IPC: C07D401/12 , C07D237/14 , C07D237/20 , C07D403/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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公开(公告)号：US11208399B2
公开(公告)日：2021-12-28
申请号：US16874862
申请日：2020-05-15
Applicant: Novartis AG
Inventor： Christopher Farady , Nina Gommermann , Philipp Janser , Angela Mackay , Henri Mattes , Nichola Smith , Catherine Fooks Solovay , Nikolaus Johannes Stiefl , Eric Vangrevelinghe , Juraj Velcicky , Anette von Matt
IPC: C07D401/12 , C07D237/14 , C07D237/20 , C07D403/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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公开(公告)号：US12168012B2
公开(公告)日：2024-12-17
申请号：US17259252
申请日：2019-07-23
Applicant: Novartis AG
Inventor： Christopher Farady , Nina Gommermann , Philipp Janser , Angela MacKay , Henri Mattes , Nikolaus Johannes Stiefl , Juraj Velcicky
IPC: A61K31/53 , A61K31/616 , A61K45/06 , C07D495/14 , C07D513/14 , C07D515/14
Abstract: The present invention relates to novel thienopyrrolotriazinacetamide compounds of Formula (I): wherein R1, R2 and R3 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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公开(公告)号：US11254653B2
公开(公告)日：2022-02-22
申请号：US16874905
申请日：2020-05-15
Applicant: Novartis AG
Inventor： Christopher Farady , Nina Gommermann , Philipp Janser , Angela Mackay , Henri Mattes , Nichola Smith , Catherine Fooks Solovay , Nikolaus Johannes Stiefl , Eric Vangrevelinghe , Juraj Velcicky , Anette von Matt
IPC: C07D401/12 , C07D237/14 , C07D237/20 , C07D403/12 , C07D413/12 , C07D451/04
Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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公开(公告)号：US20250034114A1
公开(公告)日：2025-01-30
申请号：US18917653
申请日：2024-10-16
Applicant: Novartis AG
Inventor： Xiaobin Ge , Henri Mattes , Zhicong Shi , Mei Xia , Ning Ye
IPC: C07D401/12 , A61K45/06 , C07D491/048
Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I): wherein R1, R2, R3, R4 and R5 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
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公开(公告)号：US20240067627A1
公开(公告)日：2024-02-29
申请号：US18363207
申请日：2023-08-01
Applicant: Novartis AG
Inventor： Xiaobin Ge , Henri Mattes , Zhicong Shi , Mei Xia , Ning Ye
IPC: C07D401/12 , A61K45/06 , C07D491/048
CPC classification number: C07D401/12 , A61K45/06 , C07D491/048
Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I):
wherein R1, R2, R3, R4 and R5 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
