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公开(公告)号：US20210267968A1
公开(公告)日：2021-09-02
申请号：US17319882
申请日：2021-05-13
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Anthony A. McKinney , Gary D. Tollefson , Michael Alexander Cowley
IPC: A61K31/485 , A61K31/136 , A61K31/137 , A61K31/138 , A61K31/15 , A61K31/19 , A61K31/197 , A61K31/343 , A61K31/351 , A61K31/381 , A61K31/4166 , A61K31/423 , A61K31/451 , A61K31/4525 , A61K31/55 , A61K31/5513 , A61K45/06
Abstract: Disclosed are compositions for reducing food cravings, comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound is an α-MSH agonist. Also disclosed are methods of reducing food cravings, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance α-MSH activity.
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公开(公告)号：US20240366513A1
公开(公告)日：2024-11-07
申请号：US18770144
申请日：2024-07-11
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Anthony A. McKinney , Gary D. Tollefson , Eckard Weber , Richard Soltero
IPC: A61K9/24 , A61J1/03 , A61J7/04 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36
Abstract: Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
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公开(公告)号：US20230301922A1
公开(公告)日：2023-09-28
申请号：US18143254
申请日：2023-05-04
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Anthony A. McKinney , Gary D. Tollefson , Eckard Weber , Richard Soltero
IPC: A61K9/24 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/423 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K9/00 , A61K31/42 , A61K47/26 , A61K9/20 , A61K31/357 , A61K31/551
CPC classification number: A61K9/209 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/423 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K9/0002 , A61K31/42 , A61K47/26 , A61K9/2018 , A61K9/2054 , A61K31/357 , A61K31/551
Abstract: In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
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公开(公告)号：US20210346469A1
公开(公告)日：2021-11-11
申请号：US17335646
申请日：2021-06-01
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Michael Alexander Cowley , Anthony A. McKinney , Gary D. Tollefson
IPC: A61K38/28 , A61K31/135 , A61K31/138 , A61K31/423 , A61K31/445 , A61K31/4525 , A61K31/485 , A61K31/519 , A61K31/5415 , A61K31/551 , A61K31/554 , A61K31/7048 , A61K45/06 , A61K31/55 , A61K31/5513 , A61K31/35 , A61K31/137 , A61K31/357
Abstract: Methods and compositions for treating a blood glucose condition involve identifying a suitable subject and administering an effective amount of a composition that contains one or more of an opioid antagonist, an anticonvulsant, and a psychotherapeutic agent. The compositions can include insulin. In some embodiments, such methods and compositions can be used to modulate a blood glucose level. In preferred embodiments, such methods and compositions are useful for increasing a subject's sensitivity to insulin.
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公开(公告)号：US20210299119A1
公开(公告)日：2021-09-30
申请号：US17346902
申请日：2021-06-14
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Eduardo Dunayevich , Gary D. Tollefson
IPC: A61K31/485 , A61P3/04 , A61K31/439 , A61K9/00 , A61K31/137
Abstract: Disclosed are methods of providing weight loss therapy, particularly for patients suffering from major depression.
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公开(公告)号：US12048769B2
公开(公告)日：2024-07-30
申请号：US16938443
申请日：2020-07-24
Applicant: Nalpropion Pharmaceuticals LLC
Inventor： Anthony A McKinney , Gary D. Tollefson , Eckard Weber , Richard Soltero
IPC: A61K9/24 , A61J1/03 , A61J7/04 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36
CPC classification number: A61K9/209 , A61J1/035 , A61J7/04 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36 , A61J7/0454 , A61K31/135 , A61K2300/00 , A61K31/137 , A61K2300/00 , A61K31/35 , A61K2300/00 , A61K31/42 , A61K2300/00 , A61K31/485 , A61K2300/00 , A61K31/551 , A61K2300/00
Abstract: Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
