公开(公告)号：US20240417408A1

公开(公告)日：2024-12-19

申请号：US18564799

申请日：2022-05-27

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Kazuaki SHIBATA ,  Yu KOBAYAKAWA ,  Tadashi IMAOKA ,  Toshihiro SAKAMOTO ,  Risako MIURA ,  Elisabeth HENNESSY ,  Juan DEL POZO

IPC: C07D491/052 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I) or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.