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公开(公告)号：US09365838B2
公开(公告)日：2016-06-14
申请号：US14087307
申请日：2013-11-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph Treadway
CPC classification number: C12Q1/6869 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12N9/96 , C12Q1/6818 , C12Y207/07 , C12Y207/07007 , G01N21/6428 , G01N33/582 , G01N2021/6432
Abstract: Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
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公开(公告)号：US20140206096A1
公开(公告)日：2014-07-24
申请号：US14170349
申请日：2014-01-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Joseph BARTEL , Yongfen Chen , Eric Tulsky , Joseph Treadway
CPC classification number: G01N21/6486 , B82Y5/00 , B82Y15/00 , C01B25/082 , C09K11/02 , C09K11/565 , C09K11/70 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/588 , H01L21/02392 , H01L21/02557 , H01L21/02601 , H01L21/02628 , H01L33/06
Abstract: Nanocrystals having an indium-based core and methods for making them and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide higher quantum yields than known nanocrystals of similar composition, and they provide special advantages for certain applications because of their small size.
Abstract translation: 描述了具有铟基核的纳米晶体及其制备方法和用于构建核壳纳米晶体的方法。 这些核 - 壳纳米晶体是高度稳定的并且提供比已知具有类似组成的纳米晶体更高的量子产率，并且由于它们的小尺寸，它们为某些应用提供了特殊的优点。
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3.发明授权公开(公告)号：US10084042B2
公开(公告)日：2018-09-25
申请号：US15867684
申请日：2018-01-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eric Welch , Joseph Bartel , Eric Tulsky , Joseph Treadway , Yongfen Chen
IPC: H01L29/06 , H01L33/04 , H01L31/0352 , G01N33/58 , H01L21/02 , H01L51/00 , G01N33/533 , B82Y30/00 , C30B29/60 , C30B29/48 , C30B29/40 , C30B7/00 , B82Y20/00 , B82Y40/00
CPC classification number: H01L29/0665 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/533 , G01N33/588 , H01L21/02628 , H01L31/035209 , H01L33/04 , H01L51/0007
Abstract: A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.
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公开(公告)号：US11015220B2
公开(公告)日：2021-05-25
申请号：US16123166
申请日：2018-09-06
Applicant: Life Technologies Corporation
Inventor： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph Treadway
IPC: C12Q1/6869 , C07H19/20 , C12N9/12 , C12N9/96 , C12Q1/6818 , G01N33/58 , G01N21/64
Abstract: Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
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5.发明申请公开(公告)号：US20180158907A1
公开(公告)日：2018-06-07
申请号：US15867684
申请日：2018-01-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eric WELCH , Joseph Bartel , Eric Tulsky , Joseph Treadway , Yongfen Chen
CPC classification number: H01L29/0665 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/533 , G01N33/588 , H01L21/02628 , H01L31/035209 , H01L33/04 , H01L51/0007
Abstract: A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.
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Patent Agency Ranking
公开(公告)号：US09476885B2
公开(公告)日：2016-10-25
申请号：US14590840
申请日：2015-01-06
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eric Tulsky , Kari Haley , Imad Naasani , John Mauro , Roman Rozhkov , Joseph Treadway
CPC classification number: G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
Abstract: Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
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7.发明授权公开(公告)号：US10686034B2
公开(公告)日：2020-06-16
申请号：US16107953
申请日：2018-08-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eric Welch , Joseph Bartel , Eric Tulsky , Joseph Treadway , Yongfen Chen
IPC: H01L29/06 , B82Y30/00 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/533 , H01L51/00 , H01L21/02 , G01N33/58 , H01L31/0352 , H01L33/04 , B82Y40/00 , B82Y20/00
Abstract: A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.
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公开(公告)号：US10093972B2
公开(公告)日：2018-10-09
申请号：US15166372
申请日：2016-05-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Theo Nikiforov , Daniel Mazur , Xinzhan Peng , Tommie Lloyd Lincecum , Yuri Belosludtsev , Howard Reese , Dmitriy Gremyachinskiy , Roman Rozhkov , John Mauro , Joseph Beechem , Eric Tulsky , Imad Naasani , Kari Haley , Joseph Treadway
IPC: C07K14/00 , C12Q1/6869 , C07H19/20 , C12N9/12 , C12N9/96 , C12Q1/6818 , G01N33/58 , G01N21/64
Abstract: Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.
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9.发明申请公开(公告)号：US20170186840A1
公开(公告)日：2017-06-29
申请号：US15401216
申请日：2017-01-09
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Eric WELCH , Joseph Bartel , Eric Tulsky , Joseph Treadway , Yongfen Chen
IPC: H01L29/06 , H01L33/04 , G01N33/58 , H01L31/0352
CPC classification number: H01L29/0665 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/533 , G01N33/588 , H01L21/02628 , H01L31/035209 , H01L33/04 , H01L51/0007
Abstract: A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.
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公开(公告)号：US09291566B2
公开(公告)日：2016-03-22
申请号：US14170349
申请日：2014-01-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Joseph Bartel , Yongfen Chen , Eric Tulsky , Joseph Treadway
IPC: A61K9/14 , G01N21/64 , B82Y5/00 , B82Y15/00 , C01B25/08 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/58 , H01L33/06 , C09K11/02 , C09K11/56 , C09K11/70 , H01L21/02
CPC classification number: G01N21/6486 , B82Y5/00 , B82Y15/00 , C01B25/082 , C09K11/02 , C09K11/565 , C09K11/70 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/588 , H01L21/02392 , H01L21/02557 , H01L21/02601 , H01L21/02628 , H01L33/06
Abstract: Nanocrystals having an indium-based core and methods for making them and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide higher quantum yields than known nanocrystals of similar composition, and they provide special advantages for certain applications because of their small size.
Abstract translation: 描述了具有铟基核的纳米晶体及其制备方法和用于构建核壳纳米晶体的方法。 这些核 - 壳纳米晶体是高度稳定的并且提供比已知具有类似组成的纳米晶体更高的量子产率，并且由于它们的小尺寸，它们为某些应用提供了特殊的优点。
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