公开(公告)号：US11192878B2

公开(公告)日：2021-12-07

申请号：US16609805

申请日：2018-05-11

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Jong Yeon Hwang ,  Jae Du Ha ,  Sung Yun Cho ,  Pil Ho Kim ,  Chang Soo Yun ,  Chi Hoon Park ,  Chong Ock Lee ,  Sang Un Choi ,  Joo Youn Lee ,  Sunjoo Ahn

IPC: C07D401/04 ,  A61P35/00 ,  C07D401/14

Abstract: The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

公开(公告)号：US11084824B2

公开(公告)日：2021-08-10

申请号：US16612592

申请日：2018-05-14

Applicant: Korea Research Institute of Chemical Technology

Inventor： Pilho Kim ,  Sung Yun Cho ,  Jae Du Ha ,  Hyoung Rae Kim ,  Jong Yeon Hwang ,  Chang Soo Yun ,  Hee Jung Jung ,  Chi Hoon Park ,  Chong Ock Lee ,  Chang Hoon Lee ,  Sunjoo Ahn

IPC: A61K31/519 ,  A61P25/16 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04 ,  A23L33/10

Abstract: The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

公开(公告)号：US20180111905A1

公开(公告)日：2018-04-26

申请号：US15565897

申请日：2016-04-06

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Pilho Kim ,  Hyoung Rae Kim ,  Sung Yun Cho ,  Jae Du Ha ,  Hee Jung Jung ,  Chang Soo Yun ,  Jong Yeon Hwang ,  Chi Hoon Park ,  Chong Ock Lee ,  Sunjoo Ahn ,  Chong Hak Chae

IPC: C07D239/48 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  A23L33/00 ,  A23L33/10

CPC classification number: C07D239/48 ,  A23L33/10 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/505 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.

公开(公告)号：US10369149B2

公开(公告)日：2019-08-06

申请号：US15567224

申请日：2015-12-30

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Jong Yeon Hwang ,  Hyoung Rae Kim ,  Jae Du Ha ,  Sung Yun Cho ,  Hee Jung Jung ,  Pilho Kim ,  Chang Soo Yun ,  Chong Ock Lee ,  Chi Hoon Park ,  Chong Hak Chae ,  Sunjoo Ahn

IPC: A61K31/506 ,  C07D239/30 ,  C07D239/48 ,  A23L33/10 ,  A61P35/00 ,  C07B43/04 ,  C07C13/48

Abstract: The present invention relates to a 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.

公开(公告)号：US10100019B2

公开(公告)日：2018-10-16

申请号：US15565897

申请日：2016-04-06

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Pilho Kim ,  Hyoung Rae Kim ,  Sung Yun Cho ,  Jae Du Ha ,  Hee Jung Jung ,  Chang Soo Yun ,  Jong Yeon Hwang ,  Chi Hoon Park ,  Chong Ock Lee ,  Sunjoo Ahn ,  Chong Hak Chae

IPC: C07D239/48 ,  A61K31/505 ,  A61P35/00 ,  A23L33/10 ,  A23L33/00 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.