公开(公告)号：US20160202208A1

公开(公告)日：2016-07-14

申请号：US14925172

申请日：2015-10-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Seok LEE ,  Minhong JEUN ,  Inkyu LEE ,  Jung Hoon PARK ,  Won-Ju CHO ,  Hyun-June JANG

IPC: G01N27/414

CPC classification number: G01N27/4145

Abstract: A multiplexing detection system of a dual gate ion-sensitive field effect transistor bio sensor of the present invention includes: a first dual gate ion-sensitive field effect transistor bio sensor; and a second dual gate ion-sensitive field effect transistor bio sensor, wherein a first bio signal is sensed through the first dual gate ion-sensitive field effect transistor bio sensor, and a second bio signal is sensed through the second dual gate ion-sensitive field effect transistor bio sensor, and the first bio signal and the second bio signal are different in type from each other.

Abstract translation: 本发明的双栅离子敏感场效应晶体管生物传感器的复用检测系统包括：第一双栅极离子敏感场效应晶体管生物传感器; 以及第二双栅极离子敏感场效应晶体管生物传感器，其中通过第一双栅离子敏感场效应晶体管生物传感器感测第一生物信号，并且通过第二双栅离子敏感感测第二生物信号 场效应晶体管生物传感器，第一生物信号和第二生物信号的类型彼此不同。

公开(公告)号：US20210130613A1

公开(公告)日：2021-05-06

申请号：US16855547

申请日：2020-04-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Youngdo JEONG ,  Kwan Hyi LEE ,  Hyojin LEE

IPC: C08L79/04 ,  C08G73/06 ,  A61K9/51

Abstract: Provided are positively charged nanoparticles and use thereof. According to the nanoparticles of an aspect, cucurbituril may limit electrostatic attraction between a guest for cucurbituril and a metal salt, thereby generating nanoparticles with a uniform size. Accordingly, the nanoparticles may have an effect of being capable of efficient intracellular gene delivery.

公开(公告)号：US20240002945A1

公开(公告)日：2024-01-04

申请号：US18038454

申请日：2021-11-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Youngdo JEONG ,  Ho Jun KIM ,  Sungwook PARK ,  Seongchan KIM

IPC: C12Q1/6886 ,  C12Q1/6837

CPC classification number: C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/156 ,  C12Q2600/178

Abstract: The present disclosure relates to a biosensor with surface-modified with reduced graphene oxide and a detection method using the same. The biosensor according to an aspect can effectively detect a target material in a urine sample, and thus, the use of the biosensor has an advantage in that prostate cancer can be diagnosed in a non-invasive, fast, and accurate manner.

公开(公告)号：US20190204321A1

公开(公告)日：2019-07-04

申请号：US16314253

申请日：2017-07-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Kwan Hyi LEE ,  Min Hong JEUN ,  Sung Wook PARK ,  Seung Jae MYUNG ,  Choung Soo KIM ,  Sang Yeob KIM ,  Eun Ju DO ,  Ja Young KANG

IPC: G01N33/574 ,  G01N33/543 ,  G01N27/414

CPC classification number: G01N33/57419 ,  A61B5/00 ,  G01N27/414 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/543 ,  G01N33/5438 ,  G01N33/54386 ,  G01N33/574 ,  G01N33/57484 ,  G01N2800/50

Abstract: The present invention relates to a high-sensitivity liquid field-effect sensor for colon cancer, applicable to a sample such as blood or stool. The sensor according to one aspect enables ultra-high precision/low-concentration detection of colon cancer biomarkers, thereby having an effect of enabling early diagnosis of colon cancer even with a very small amount of a sample.

公开(公告)号：US20240011996A1

公开(公告)日：2024-01-11

申请号：US18038453

申请日：2021-11-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Ho Jun KIM ,  Youngdo JEONG ,  Sungwook PARK

IPC: G01N33/574

CPC classification number: G01N33/57492 ,  G01N33/57434 ,  G01N33/57488

Abstract: The present disclosure relates to a biomarker for diagnosis of prostate cancer and use of the biomarker. According to a biomarker composition for diagnosis of prostate cancer of the present disclosure, an optimal biomarker combination capable of effectively diagnosing prostate cancer has been discovered, and there is an advantage in that prostate cancer can be diagnosed with high accuracy by using the biomarker combination and a machine learning algorithm model.

公开(公告)号：US20180364194A1

公开(公告)日：2018-12-20

申请号：US15684939

申请日：2017-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Minhong JEUN ,  Seok LEE ,  Sang Kyung KIM ,  Sungwook PARK

IPC: G01N27/414 ,  H01L29/45

Abstract: Provided is a field-effect transistor that can reduce noise, be produced by a simplified manufacturing method, and also have a plurality of active patterns and gate patterns designed to be combinable according to a detection purpose. The field-effect transistor includes a lower silicon layer and a buried oxide layer disposed on the lower silicon layer; an active pattern disposed on the buried oxide layer and including a channel region, a source region, and a drain region; a gate pattern disposed on the active pattern to at least partially overlap the active pattern; a source electrode disposed in direct contact with the source region on the active pattern, and a drain electrode disposed in direct contact with the drain region on the active pattern; and a gate insulating film disposed between the active pattern and the gate pattern.

公开(公告)号：US20170219518A1

公开(公告)日：2017-08-03

申请号：US15371284

申请日：2016-12-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Kwan Hyi LEE ,  Min Hong JEUN ,  Sung Wook PARK ,  Seung Jae MYUNG ,  Choung Soo KIM ,  In Gab JEONG ,  Sang Hoon SONG

IPC: G01N27/414 ,  C12Q1/68 ,  G01N33/493 ,  G01N33/543 ,  G01N33/574

CPC classification number: G01N27/4145 ,  C12Q1/682 ,  C12Q1/6825 ,  G01N27/4146 ,  G01N33/493 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/57434 ,  G01N33/57484 ,  G01N33/587

Abstract: Provided is a semiconductor-based ion-responsive urine sensor (IRUS) capable of detecting an analyte in urine by a non-invasive method. When a urine sensor according to an aspect is used, it is possible to diagnose a patient accurately in a comfortable condition and to use the urine sensor for point-of-care (POC) diagnosis.

公开(公告)号：US20160041172A1

公开(公告)日：2016-02-11

申请号：US14486251

申请日：2014-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Hyun Kwang Seok ,  Seok Lee ,  Gunhyuk Jang ,  Minhong Jeun

IPC: G01N33/574 ,  G01N33/569

CPC classification number: G01N33/57434 ,  G01N33/56983 ,  G01N33/57411 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/085 ,  G01N2333/09 ,  G01N2333/11 ,  G01N2333/16

Abstract: The present disclosure relates to a composition or a kit that can be used for detection or diagnosis of various diseases.

Abstract translation: 本公开涉及可用于各种疾病的检测或诊断的组合物或试剂盒。

公开(公告)号：US20150198532A1

公开(公告)日：2015-07-16

申请号：US14292197

申请日：2014-05-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Minhong JEUN ,  Yu Chan KIM ,  Seok LEE ,  Hyun Kwang SEOK

IPC: G01N21/64 ,  C07K16/08

CPC classification number: G01N33/54326 ,  C07K16/082 ,  G01N33/588 ,  G01N33/90 ,  G01N2021/6439

Abstract: The invention relates to a biomarker detecting probe which is capable of early detection of a biomarker and precise quantification thereof at the same time, and a method of detecting a biomarker using the same. More particularly, it relates to a biomarker detecting probe comprising a ferritin protein, and a targeting antibody linked with a fluorescent material, superparamagnetic nano particle, and conductive particle, and a method of detecting a biomarker using the same.

Abstract translation: 本发明涉及能够同时早期检测生物标志物和精确定量的生物标志物检测探针，以及使用其的生物标志物的检测方法。 更具体地，本发明涉及包含铁蛋白的生物标志物检测探针和与荧光材料，超顺磁性纳米颗粒和导电性粒子连接的靶向抗体，以及使用其的生物标志物的检测方法。

公开(公告)号：US20140170767A1

公开(公告)日：2014-06-19

申请号：US14093305

申请日：2013-11-29

Applicant: Korea Institute of Science and Technology

Inventor： Kwan Hyi LEE ,  Ho Young PARK ,  Yu Chan KIM ,  Hyun Kwang SEOK ,  Seok LEE

IPC: G01N33/543

CPC classification number: G01N33/54326

Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.

Abstract translation: 提供了使用磁性粒子和量子点进行定量分析的生物标志物的诊断方法以及生物标志物诊断试剂盒。 用于诊断生物标志物的方法包括：ii）提供具有表面的磁性颗粒，所述表面能够使用接头固定生物标志物的一级抗体; ii）提供具有能够检测生物标志物的二级抗体固定的表面的量子点; iii）通过磁性颗粒和量子点夹心靶向生物标志物; iv）选择性地分离量子点之间的夹心靶向生物标志物的量子点; 和v）通过测量分离的量子点的荧光的吸光度或强度来量化生物标志物的浓度。