公开(公告)号：US20210196608A1

公开(公告)日：2021-07-01

申请号：US17138312

申请日：2020-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Sungdo HA ,  Seok LEE ,  Jin-Chul KIM ,  Pilju CHOI ,  Bong Geun SONG

IPC: A61K8/49 ,  C07D311/80 ,  A23L33/105 ,  A23L5/30

Abstract: Provided are: a method of preparing a Cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a Cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

公开(公告)号：US20210308648A1

公开(公告)日：2021-10-07

申请号：US17221591

申请日：2021-04-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Sungdo HA ,  Seok LEE ,  Young Tae PARK ,  Pilju CHOI

IPC: B01J19/12

Abstract: A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.

公开(公告)号：US20210100864A1

公开(公告)日：2021-04-08

申请号：US17035690

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Seok LEE ,  Bong Geun SONG ,  Sungdo HA ,  Young Tae PARK ,  Pilju CHOI ,  Hoon RYU

IPC: A61K36/185 ,  A61K31/05 ,  A23L33/105 ,  A61K8/34 ,  A61K8/9789 ,  B01J19/12

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US20210002247A1

公开(公告)日：2021-01-07

申请号：US16916920

申请日：2020-06-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Sungdo HA ,  Seok LEE ,  Deok Ha WOO ,  Pilju CHOI ,  Bong Geun SONG

IPC: C07D311/80 ,  A61K8/49 ,  A61Q19/00 ,  A23L33/105 ,  B01D11/02

Abstract: Provided are a method of preparing a cannabis processed product having an increased Δ9-THC content in an efficient and economic manner, through a cyclization reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased Δ9-THC content prepared by the method, a fraction thereof, and a single ingredient of THC, in foods, drugs, and cosmetics.

公开(公告)号：US20180280456A1

公开(公告)日：2018-10-04

申请号：US15935634

申请日：2018-03-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Bong Chul CHUNG ,  Taejung KIM ,  Pilju CHOI ,  Ki Sung KANG ,  Buyng Su HWANG ,  Kyu Sun KIM

IPC: A61K36/062 ,  A61P3/10 ,  A61K31/122 ,  A61K31/05

Abstract: Provided are a composition for stimulating insulin secretion from cells, the composition including a Hypoxylon truncatum extract or an active ingredient thereof, and a method of stimulating insulin secretion from cells.

公开(公告)号：US20150336938A1

公开(公告)日：2015-11-26

申请号：US14760400

申请日：2014-01-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Tae Jung KIM ,  Hak Cheol KWON ,  Kyu Hyuk JEONG ,  Jungho SONG ,  Bong Chul CHUNG

IPC: C07D407/04 ,  C07D405/04 ,  C07D493/04 ,  C07D307/88 ,  C07D409/04

CPC classification number: C07D307/88 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D493/04

Abstract: The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

Abstract translation: 本公开涉及一种制备芳基萘酚化合物的新方法。 在根据本公开的芳基萘木酚素化合物和衍生物的合成中，可以首先构建萘主链，并且可以在最后阶段引入芳基。 通过这种方法，可以有效地合成不能用现有方法准备的各种衍生物。 此外，根据本公开的合成方法适用于大规模生产。