公开(公告)号：USRE38425E1

公开(公告)日：2004-02-10

申请号：US09556910

申请日：2000-04-20

申请人： Jonathan Richard Dimmock ,  Ramanan Narayan Puthucode

发明人： Jonathan Richard Dimmock ,  Ramanan Narayan Puthucode

IPC分类号： A61K31375

CPC分类号： C07C281/14

摘要： A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: wherein: R1, R2, R3 and R4 may be the same or different and each represents a hydrogen or halogen atom, or a C1-9 alkyl, C3-9cycloalkyl, cyano, C1-9alkoxy or C6-10aryloxy group; R5 represents a hydrogen atom or a C1-9alkyl, C3-9cycloalkyl or C6-10aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.

公开(公告)号：US5741818A

公开(公告)日：1998-04-21

申请号：US475313

申请日：1995-06-07

申请人： Jonathan Richard Dimmock

发明人： Jonathan Richard Dimmock

IPC分类号： A61K31/175 ,  A61P25/00 ,  A61P25/08 ,  C07C281/14

CPC分类号： C07C281/14

摘要： A compound of general formula I below useful as an anticonvulsant for disorders of the central nervous system: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen or halogen atom, or a C.sub.1-9 alkyl, C.sub.3-9 cycloalkyl, cyano, C.sub.1-9 alkoxy or C.sub.6-10 aryloxy group; R.sup.5 represents a hydrogen atom or a C.sub.1-9 alkyl, C.sub.3-9 cycloalkyl or C.sub.6-10 aryl group; and X is oxygen or sulfur; or a pharmaceutically-acceptable salt thereof. The compound may be adimistered orally for treating convulsions in humans or animals.

摘要翻译： 可用作中枢神经系统疾病的抗惊厥药的下式通式I的化合物：其中：R1，R2，R3和R4可以相同或不同，各自表示氢或卤素原子，或C1- 烷基，C3-9环烷基，氰基，C1-9烷氧基或C6-10芳氧基; R5表示氢原子或C1-9烷基，C3-9环烷基或C6-10芳基; X为氧或硫; 或其药学上可接受的盐。 该化合物可以口服给药以治疗人或动物的抽搐。