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公开(公告)号:US20050072686A1
公开(公告)日:2005-04-07
申请号:US10671694
申请日:2003-09-29
Applicant: John Shaw , Richard Shute
Inventor: John Shaw , Richard Shute
IPC: B01J19/00 , B01J19/08 , C07C1/26 , C07C29/70 , C07F1/00 , C07F1/04 , C07F3/02 , C07F7/22 , C07F9/535 , C25B3/00 , C25B3/12 , C25B9/00 , C25B11/03 , C25D17/00
CPC classification number: C25B3/12 , B01J19/0093 , B01J2219/00835 , B01J2219/00853 , B01J2219/0086 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00936 , B01J2219/00995 , C07C1/26 , C07F1/00 , C07F1/04 , C07F3/02 , C07F7/2208 , C07F9/5352 , C25B3/00 , C07C15/04
Abstract: The invention relates to a micro-engineered reactor device comprising a closely coupled reactor and electrochemical cell, and a method of using such a reactor for the synthesis of organic compounds by a process involving an electrochemical reaction. The synthetic processes are of a type in which a source material is electrochemically converted to a reactive primary product which is exposed at a reaction region within a channel, or chamber, to a precursor material so that the primary product and precursor material react to generate a secondary product.
Abstract translation: 本发明涉及包括紧密耦合的反应器和电化学电池的微型工程反应器装置,以及使用这种反应器通过涉及电化学反应的方法合成有机化合物的方法。 合成方法是将源材料电化学转化为在通道或室内的反应区域暴露于前体材料的反应性初级产物的类型,使得初级产物和前体材料反应以产生 次要产品。
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公开(公告)号:US20050002835A1
公开(公告)日:2005-01-06
申请号:US10836250
申请日:2004-05-03
Applicant: John Shaw , Richard Shute
Inventor: John Shaw , Richard Shute
IPC: B01F3/20 , B01F5/06 , B01F13/00 , B01J19/00 , B01J19/12 , C07B61/00 , C07C2/42 , C07C13/44 , C07C243/26 , C07C247/20 , C07C247/22 , C07C263/12 , C07C273/18 , C40B60/14
CPC classification number: C40B60/14 , B01F3/20 , B01F3/2035 , B01F3/2085 , B01F5/06 , B01F13/0001 , B01F13/0059 , B01F13/0093 , B01J19/0093 , B01J2219/00286 , B01J2219/0031 , B01J2219/00479 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01J2219/00783 , B01J2219/00869 , B01J2219/00871 , B01J2219/00943 , C07C247/22 , C07C273/1809
Abstract: A chemical reactor and method of using the same. The reactor comprises first and second micro-engineered discrete flow passages for receiving chemical fluids. The first fluid passage receives a first chemical fluid in which a chemical change or reaction in the fluid can be initiated by subjecting the fluid to a stimulus. A stimulation means is located in, or adjacent to, the first flow passage, and is operable to stimulate a chemical change or reaction in the first fluid. The second micro-engineered discrete flow passage receives a second chemical fluid which will interact with the stimulated first fluid when contacted by the stimulated first fluid. The first and second flow passages converge at a first region to form an outlet passage within which the first and second fluids may contact each other.
Abstract translation: 一种化学反应器及其使用方法。 反应器包括用于接收化学流体的第一和第二微型工程离散流动通道。 第一流体通道接收第一化学流体,其中可以通过使流体经受刺激来引发流体中的化学变化或反应。 刺激装置位于或邻近第一流动通道,并且可操作以刺激第一流体中的化学变化或反应。 第二微型工程离散流动通道接收第二化学流体,当被受刺激的第一流体接触时,该第二化学流体将与受刺激的第一流体相互作用。 第一和第二流动通道在第一区域处会聚,以形成第一和第二流体可以彼此接触的出口通道。
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公开(公告)号:US20070179315A1
公开(公告)日:2007-08-02
申请号:US10593212
申请日:2005-03-18
Applicant: Andrew Holmes , Catherine Smith , Melanie Tsang , Theresa Early , Richard Shute
Inventor: Andrew Holmes , Catherine Smith , Melanie Tsang , Theresa Early , Richard Shute
IPC: C07C209/00
CPC classification number: C07C227/08 , C07C209/10 , C07C213/02 , C07D207/325 , C07D207/327 , C07C211/55 , C07C217/92 , C07C229/60
Abstract: A method of synthesizing a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is a labile leaving group; RN1 is optionally substituted C5-20 aryl; RN2 is selected from optionally substituted C5-20aryl, optionally substituted C3-20 heterocyclyl, optionally substituted C3-7 alkyl, and optionally substituted sulfonyl; RN3 is selected from H and optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl; or RN2 and RN3 together with the nitrogen atom to which they are attached form optionally substituted nitrogen-containing C3-20 heterocylyl or C5-20 heteroaryl; and R1 R2 and R3 are independently selected from optionally substituted C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, hydroxy, halo, amino and C1-7 alkoxy, or two of R1, R2 and R3, together with the silicon atom to which they are attached, may form a silicon containing C5-7 heterocyclyl group.
Abstract translation: 合成式I化合物的方法:包括使式II部分与式III部分反应的步骤:在过渡金属催化剂和碱的存在下,在压缩二氧化碳中,其中L是不稳定的离去 组; R 01是任选取代的C 5-20芳基; R N2选自任选取代的C 5-20芳基,任选取代的C 3-20杂环基,任选取代的C 3-8芳基, 7烷基和任选取代的磺酰基; R N 3选自H和任选取代的C 1-7 - 烷基,C 3-20 - 杂环基和C 5-20杂环基, / SUB>芳基; 或R N2和R N3与它们所连接的氮原子一起形成任选取代的含氮C 3-20异氰酸酯或C 5-20杂芳基; R 1和R 3独立地选自任选取代的C 1-7烷基,C 1 -C 6烷基, 羟基,卤素,氨基和C 1-7 - 烷氧基,或者R 1,R 2,R 2, 1,R 2和R 3与它们所连接的硅原子一起可以形成含有C 5-7的硅, / SO 2杂环基。