公开(公告)号：US20190055181A1

公开(公告)日：2019-02-21

申请号：US16070687

申请日：2017-02-13

Applicant: Givaudan, S.A.

Inventor： Simon ELLWOOD ,  William Alexander THIAM

IPC: C07C45/51 ,  C07C41/01 ,  C07C41/30 ,  C07C41/18 ,  C07C49/557

Abstract: A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalisation reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.