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    APPARATUS FOR THE SEPARATION OF PLASMA
    1.
    发明申请
    APPARATUS FOR THE SEPARATION OF PLASMA 有权
    用于分离等离子体的装置

    公开(公告)号：US20110011781A1

    公开(公告)日：2011-01-20

    申请号：US12867335

    申请日：2009-02-26

    Applicant: Gert Blankenstein ,  Holger Bartos ,  Ralf-Peter Peters ,  Christian Schoen

    Inventor： Gert Blankenstein ,  Holger Bartos ,  Ralf-Peter Peters ,  Christian Schoen

    IPC: B01D63/00 ,  B01D35/00 ,  B01D35/02

    CPC classification number: B01L3/502753 ,  B01D29/014 ,  B01D29/05 ,  B01D61/18 ,  B01D63/08 ,  B01D63/087 ,  B01D63/088 ,  B01D2201/0415 ,  B01D2201/44 ,  B01L3/502715 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/0406 ,  G01N33/491

    Abstract: The invention relates to an apparatus for separating blood, more particularly an apparatus (1) for absorbing blood (19) and separating blood components, e.g. blood plasma, as a sample liquid (2). Said apparatus (1) comprises a feeding device (13) for absorbing the blood (2), a device (15) for separating blood components as a sample liquid (2), a duct which preferably absorbs the sample liquid (2) exclusively by means of capillary forces, and a device for filling the duct (3) with sample liquid (2) in an inlet or feeding zone (18) of the duct (3). The separating device (15), in particular a membrane, is curved, especially convexly shaped, and the apex of said curved, especially convex shape projects into the filling device.

    Abstract translation: 本发明涉及一种用于分离血液的装置，更具体地说，涉及用于吸收血液（19）并分离血液成分的装置（1）。 血浆，作为样品液体（2）。 所述装置（1）包括用于吸收血液（2）的供给装置（13），用于分离作为样品液体（2）的血液成分的装置（15），优选地通过以下方式吸收样品液体 以及用于在管道（3）的入口或进料区（18）中用样品液体（2）填充管道（3）的装置。 分离装置（15），特别是膜是弯曲的，特别是凸形的，并且所述弯曲的，特别是凸形的顶点突出到填充装置中。

    PLASMA SEPARATION RESERVOIR
    4.
    发明申请
    PLASMA SEPARATION RESERVOIR 有权
    等离子体分离储器

    公开(公告)号：US20120118392A1

    公开(公告)日：2012-05-17

    申请号：US13381148

    申请日：2010-06-08

    Applicant: Gert Blankenstein ,  Christian Schoen

    Inventor： Gert Blankenstein ,  Christian Schoen

    IPC: E03B7/07 ,  B01D63/00

    CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/086 ,  B01L2400/088 ,  G01N33/491 ,  Y10T137/0318 ,  Y10T137/794

    Abstract: The invention relates to a microfluidic apparatus for producing a volume flow that is uniform over time in a metering process. In various solution processes or reaction processes it is essential to have a specified given volume flow or mass flow of fluid available to ensure reliable dissolution of the reagent or ensure that the reaction takes place. In microfluidic apparatus in which separation of particles from a fluid, particularly blood, is carried out through a membrane, the volume flow through the membrane decreases continuously. In order to achieve a uniform volume flow during metering, it is envisaged that first of all a reservoir is filled from a first channel, so that the contents of the reservoir can then be fed to the metering process by opening a fluid stop. The emptying of the reservoir takes place with a uniform volume flow of 0.05 microlitres per second to 10 microlitres per second.

    Abstract translation: 本发明涉及用于在计量过程中产生随时间均匀的体积流的微流体装置。 在各种溶液方法或反应过程中，必须具有指定的给定体积流量或质量流量的流体，以确保试剂的可靠溶解或确保反应发生。 在通过膜进行颗粒与流体特别是血液分离的微流体装置中，通过膜的体积流量连续减小。 为了在计量期间实现均匀的体积流量，设想首先从第一通道填充储存器，以便随后通过打开流体阻塞将储存器的内容物送入计量过程。 储存器的排空以0.05微升/秒至10微升/秒的均匀体积流量进行。

    Device and process for testing a sample liquid
    5.
    发明申请
    Device and process for testing a sample liquid 审中-公开
    用于测试样品液体的装置和过程

    公开(公告)号：US20060216195A1

    公开(公告)日：2006-09-28

    申请号：US11340837

    申请日：2006-01-27

    Applicant: Gert Blankenstein ,  Ralf-Peter Peters ,  Thomas Willms ,  Claus Marquordt ,  Christian Schoen

    Inventor： Gert Blankenstein ,  Ralf-Peter Peters ,  Thomas Willms ,  Claus Marquordt ,  Christian Schoen

    IPC: G01N31/22

    CPC classification number: B01L3/502738 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2300/165 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086

    Abstract: A device and a process for testing a sample liquid wherein the sample liquid flows laminarly by capillary forces over a flat side of a channel to completely filling a reaction area which has a soluble and/or reacting reagent on the flat side and defines a reaction volume of the sample liquid, the reaction volume being temporarily stopped in the reaction area for dissolving or reacting at least 90% of the reagent in the defined reaction volume of the sample liquid, and at least 90% of the dissolved reagent or a reaction product, after stopping, flows together with the reaction volume into the test area which is formed by the channel downstream of the reaction area, the sample liquid flowing with an at least essentially straight liquid front and/or at least essentially without a change in the flow cross section from the reaction area into the test area.

    Abstract translation: 一种用于测试样品液体的装置和方法，其中样品液体通过毛细管在通道的平坦侧面上层流地流动，以在平坦侧面上完全填充具有可溶性和/或反应试剂的反应区域，并限定反应体积 的样品液体的反应体积暂时停留在反应区域中，用于使至少90％的试剂溶解或反应在试样液体的规定反应体积中，并且至少90％的溶解试剂或反应产物， 在停止后，与反应体积一起流入由反应区域下游的通道形成的测试区域，样品液体以至少基本上直的液体前部和/或至少基本上没有流动交叉的变化流动 部分从反应区进入试验区。

    Component of a biosensor and process for production
    10.
    发明授权
    Component of a biosensor and process for production 有权
    生物传感器的组成部分和生产过程

    公开(公告)号：US09364807B2

    公开(公告)日：2016-06-14

    申请号：US13635972

    申请日：2011-03-10

    Applicant: Christian Schoen ,  Michael Wagner

    Inventor： Christian Schoen ,  Michael Wagner

    IPC: B01J4/00 ,  B01D3/00 ,  B81C1/00 ,  B01L3/00

    CPC classification number: B01J4/001 ,  B01L3/502707 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/088 ,  B81C1/00047 ,  B81C1/00063 ,  B81C2201/0105 ,  B81C2201/0143 ,  B81C2201/0156 ,  Y10T137/85938

    Abstract: The invention relates to a component (4) of a biosensor, comprising at least one first device (6) for receiving a sample liquid, wherein the device (6) is connected via a distributor channel (7) to further receiving devices (8 to 11), into each of which a feed channel (71, 72, 73, 74) branching off from the distributor channel (7) opens, and the feed channels (71, 72, 73, 74) are arranged in succession in flow direction (S) of the sample liquid passed on through the distributor channel (7). In accordance with the invention, it is envisaged that, in the distributor channel (7), in each case between two immediately successive feed channels (71, 72; 72, 73; 73, 74) in flow direction (S), at least one region (K) for at least temporary slowing or stoppage of the capillary flow of the sample liquid has been inserted. It is thus possible to control the capillary flow of the sample liquid such that always only one receiving device (8, 9, 10, 11) is filled with the volume flow of sample liquid available before the next is filled, and effectively simultaneous filling of the receiving devices (8, 9, 10, 11) is prevented. This leads to rapid and complete filling of the respective receiving device (8, 9, 10, 11). Additionally presented is a process with which the regions (K) can be inserted into the distributor channel (7) in a simple manner.

    Abstract translation: 本发明涉及生物传感器的组件（4），其包括用于接收样品液体的至少一个第一装置（6），其中所述装置（6）经由分配器通道（7）连接到另外的接收装置（8至 其中，从分配器通道（7）分支出的进料通道（71,72,73,74）打开，并且进料通道（71,72,73,74）在流动方向上连续地排列 （S）通过分配器通道（7）通过的样品液体。 根据本发明，设想在分配器通道（7）中，在每种情况下，在流动方向（S）处的两个紧邻的供给通道（71,72; 72,73; 73,74）之间至少 已经插入了用于至少暂时放慢或停止样品液体的毛细管流动的区域（K）。 因此，可以控制样品液体的毛细管流动，使得总是只有一个接收装置（8,9,10,11）填充下一个填充之前可用的样品液体的体积流量，并且有效地同时填充 接收装置（8,9,10,11）被防止。 这导致相应的接收装置（8,9,10,11）的快速和完全的填充。 另外提出了一种可以简单地将区域（K）插入到分配器通道（7）中的过程。

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