公开(公告)号：US10092692B2

公开(公告)日：2018-10-09

申请号：US15783963

申请日：2017-10-13

Applicant: Gearbox, LLC

Inventor： Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

IPC: A61N1/18 ,  A61M35/00 ,  A61M5/142 ,  A61B5/00 ,  A61M5/172 ,  A61B5/0402 ,  A61M5/168 ,  A61M37/00 ,  A61B5/0476 ,  A61B5/0205 ,  A61B5/021

Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

公开(公告)号：US20180104407A1

公开(公告)日：2018-04-19

申请号：US15783963

申请日：2017-10-13

Applicant: Gearbox, LLC

Inventor： Ralph G. Dacey, JR. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood ,  Gregory J. Zipfel

IPC: A61M5/142 ,  A61B5/00

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

公开(公告)号：US09789315B2

公开(公告)日：2017-10-17

申请号：US15173957

申请日：2016-06-06

Applicant: Gearbox, LLC

Inventor： Ralph G. Dacey, Jr. ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt

IPC: A61N1/18 ,  A61M35/00 ,  A61N1/36 ,  A61B5/11 ,  A61B5/00 ,  A61F7/00 ,  A61M5/142 ,  A61M5/172 ,  A61M37/00 ,  A61N1/04 ,  A61N7/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/145 ,  A61M5/168 ,  A61N1/30 ,  A61N1/32 ,  A61N1/372 ,  A61N2/00

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

公开(公告)号：US20190038831A1

公开(公告)日：2019-02-07

申请号：US16154036

申请日：2018-10-08

Applicant: Gearbox LLC

Inventor： Ralph G. Dacey, JR. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood ,  Gregory J. Zipfel

IPC: A61M5/142 ,  A61N1/36 ,  A61B5/11 ,  A61N1/32 ,  A61F7/00 ,  A61M37/00 ,  A61B5/00

Abstract: Methods and related systems for modulating neural activity by modulating neural activity in a nerve plexus of a subject are disclosed. Neural activity may be modulated by stimuli delivered via various types of stimulus sources. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain. Delivery of stimuli for modulating neural activity may be controlled in part in based on an activity state of the subject.

公开(公告)号：US20160354606A1

公开(公告)日：2016-12-08

申请号：US15173957

申请日：2016-06-06

Applicant: Gearbox, LLC

Inventor： Ralph G. Dacey, JR. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood ,  Gregory J. Zipfel

IPC: A61N1/36 ,  A61N2/00 ,  A61M35/00 ,  A61N1/32 ,  A61N1/30 ,  A61F7/00 ,  A61M5/142 ,  A61N7/00 ,  A61M37/00

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

Abstract translation: 公开了通过循环调节外周神经结构中的神经活动来调节神经活动的方法和相关系统。 神经活动可以通过经由各种类型的刺激源递送的刺激来周期性地调节。 在一方面，调节感觉神经的活动。 例如，可以使用神经调节来调节不期望的感觉，例如疼痛，或免疫或炎症反应或过程。 可以部分地响应于来自用户输入装置的输入来控制用于调节神经活动的刺激的递送。