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公开(公告)号：US20200291113A1
公开(公告)日：2020-09-17
申请号：US16723809
申请日：2019-12-20
Applicant: CytomX Therapeutics, Inc.
Inventor： James William WEST , Jason Gary Sagert , Jonathan Alexander Terrett , Annie Yang Weaver , Luc Roland Desnoyers , Shweta Singh
IPC: C07K16/28 , A61K47/68 , A61K31/537
Abstract: The invention relates generally to antibodies that bind CD166, activatable antibodies that specifically bind to CD166 and methods of making and using these anti-CD166 antibodies and anti-CD166 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US10179817B2
公开(公告)日：2019-01-15
申请号：US15146294
申请日：2016-05-04
Applicant: CytomX Therapeutics, Inc.
Inventor： Jason Gary Sagert , Kimberly Ann Tipton , Jonathan Alexander Terrett , Shweta Singh , Annie Yang Weaver , Luc Roland Desnoyers
Abstract: The invention relates generally to antibodies that bind CD71, activatable antibodies that specifically bind to CD71 and methods of making and using these anti-CD71 antibodies and anti-CD71 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US20170072067A1
公开(公告)日：2017-03-16
申请号：US15359100
申请日：2016-11-22
Applicant: CytomX Therapeutics, Inc.
Inventor： Henry Bernard Lowman , Luc Roland Desnoyers , Tony W. Liang , Andrei William Konradi , Shweta Singh
CPC classification number: A61K39/3955 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K49/00 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/00
Abstract: The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.
Abstract translation: 本发明一般涉及用于缀合抗体和可激活抗体的组合物和方法，以及在缀合之前部分还原抗体和/或可激活抗体的方法，例如基于硫醇的缀合，与试剂，例如治疗和/或诊断剂 。
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4.发明申请ANTI-ITGA3 ANTIBODIES, ACTIVATABLE ANTI-ITGA3 ANTIBODIES, AND METHODS OF USE THEREOF 审中-公开抗ITGA3抗体，可激活的抗ITGA3抗体及其使用方法
公开(公告)号：US20160355592A1
公开(公告)日：2016-12-08
申请号：US15146868
申请日：2016-05-04
Applicant: CytomX Therapeutics, Inc.
Inventor： Jason Gary Sagert , Jonathan Alexander Terrett , Luc Roland Desnoyers , Shweta Singh , Annie Yang Weaver
CPC classification number: C07K16/2839 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K16/2842 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/732 , C07K2317/92 , C07K2319/00 , C07K2319/50
Abstract: The invention relates generally to antibodies that bind ITGa3, activatable antibodies that specifically bind to ITGa3 and methods of making and using these anti-ITGa3 antibodies and anti-ITGa3 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
Abstract translation: 本发明一般涉及结合ITGa3，特异性结合ITGa3的可激活抗体的抗体以及在各种治疗，诊断和预防指征中制备和使用这些抗ITGa3抗体和抗ITGa3可激活抗体的方法。
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公开(公告)号：US11753466B2
公开(公告)日：2023-09-12
申请号：US16723809
申请日：2019-12-20
Applicant: CytomX Therapeutics, Inc.
Inventor： James William West , Jason Gary Sagert , Jonathan Alexander Terrett , Annie Yang Weaver , Luc Roland Desnoyers , Shweta Singh
IPC: C07K16/28 , A61K47/68 , A61K31/537 , A61K39/00
CPC classification number: C07K16/2803 , A61K31/537 , A61K47/6873 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/50 , C07K2319/55
Abstract: The invention relates generally to antibodies that bind CD166, activatable antibodies that specifically bind to CD166 and methods of making and using these anti-CD166 antibodies and anti-CD166 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US20190309072A1
公开(公告)日：2019-10-10
申请号：US16251919
申请日：2019-01-18
Applicant: CytomX Therapeutics, Inc.
Inventor： Jason Gary SAGERT , Jonathan Alexander Terrett , Luc Roland Desnoyers , Shweta Singh , Annie Yang Weaver
Abstract: The invention relates generally to antibodies that bind ITGa3, activatable antibodies that specifically bind to ITGa3 and methods of making and using these anti-ITGa3 antibodies and anti-ITGa3 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US11992528B2
公开(公告)日：2024-05-28
申请号：US17227004
申请日：2021-04-09
Applicant: CytomX Therapeutics, Inc.
Inventor： Henry Bernard Lowman , Luc Roland Desnoyers , Tony W. Liang , Andrei William Konradi , Shweta Singh
CPC classification number: A61K39/3955 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K49/00 , C07K16/18 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/00
Abstract: The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.
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公开(公告)号：US10577420B2
公开(公告)日：2020-03-03
申请号：US15146603
申请日：2016-05-04
Applicant: CytomX Therapeutics, Inc.
Inventor： James William West , Jason Gary Sagert , Jonathan Alexander Terrett , Annie Yang Weaver , Luc Roland Desnoyers , Shweta Singh
IPC: C07K16/28 , A61K31/537 , A61K39/00
Abstract: The invention relates generally to antibodies that bind CD166, activatable antibodies that specifically bind to CD166 and methods of making and using these anti-CD166 antibodies and anti-CD166 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US10233244B2
公开(公告)日：2019-03-19
申请号：US15146868
申请日：2016-05-04
Applicant: CytomX Therapeutics, Inc.
Inventor： Jason Gary Sagert , Jonathan Alexander Terrett , Luc Roland Desnoyers , Shweta Singh , Annie Yang Weaver
Abstract: The invention relates generally to antibodies that bind ITGa3, activatable antibodies that specifically bind to ITGa3 and methods of making and using these anti-ITGa3 antibodies and anti-ITGa3 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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公开(公告)号：US09517276B2
公开(公告)日：2016-12-13
申请号：US14296207
申请日：2014-06-04
Applicant: CytomX Therapeutics, Inc.
Inventor： Henry Bernard Lowman , Luc Roland Desnoyers , Tony W. Liang , Andrei William Konradi , Shweta Singh
CPC classification number: A61K47/48715 , A61K39/3955 , A61K47/6803 , A61K47/6851 , A61K47/6889 , A61K49/00 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K2317/21 , C07K2317/76
Abstract: The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.
Abstract translation: 本发明一般涉及用于缀合抗体和可激活抗体的组合物和方法，以及在缀合之前部分还原抗体和/或可激活抗体的方法，例如基于硫醇的缀合，与试剂，例如治疗和/或诊断剂 。
