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公开(公告)号:US09701706B2
公开(公告)日:2017-07-11
申请号:US15358938
申请日:2016-11-22
Applicant: Chimerix, Inc. , The Regents of The University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , John C. Drach , Ernest Randall Lanier, Jr. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
IPC: A01N43/04 , A61K31/70 , C07H19/14 , A61K31/7064 , A61K31/706 , A61K31/7052
CPC classification number: C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US10941175B2
公开(公告)日:2021-03-09
申请号:US16533194
申请日:2019-08-06
Applicant: Chimerix, Inc. , The Regents of the University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , Aaron Leigh Downey , John C. Drach , Ernest Randall Lanier, Jr. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
IPC: A01N43/04 , A61K31/70 , C07H19/14 , C07D239/70 , C07H19/16 , A61K31/7052 , A61K31/706 , A61K31/7064
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US09708359B2
公开(公告)日:2017-07-18
申请号:US15231528
申请日:2016-08-08
Applicant: Chimerix, Inc. , The Regents of the University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , Aaron Leigh Downey , John C. Drach , Ernest Randall Lanier, Jr. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
IPC: C07C19/14 , C07H19/16 , C07D239/70 , C07H19/14
CPC classification number: C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US20170253628A1
公开(公告)日:2017-09-07
申请号:US15599056
申请日:2017-05-18
Applicant: Chimerix, Inc. , The Regents of The University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , Aaron Leigh Downey , John C. Drach , Ernest Randall Lanier, JR. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
CPC classification number: C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US20170137454A1
公开(公告)日:2017-05-18
申请号:US15358938
申请日:2016-11-22
Applicant: Chimerix, Inc. , The Regents of The University of Michigan
Inventor: Roy W. Ware , Leroy Townsend , John C. Drach
IPC: C07H19/14
CPC classification number: C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US11981700B2
公开(公告)日:2024-05-14
申请号:US17159451
申请日:2021-01-27
Applicant: Chimerix, Inc. , The Regents of the University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , Aaron Leigh Downey , John C. Drach , Ernest Randall Lanier, Jr. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
IPC: A01N43/04 , A61K31/70 , C07D239/70 , C07H19/14 , C07H19/16 , A61K31/7052 , A61K31/706 , A61K31/7064
CPC classification number: C07H19/14 , C07D239/70 , C07H19/16 , A61K31/7052 , A61K31/706 , A61K31/7064
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
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公开(公告)号:US10407457B2
公开(公告)日:2019-09-10
申请号:US15599056
申请日:2017-05-18
Applicant: Chimerix, Inc. , The Regents of The University of Michigan
Inventor: John Henry Bougher, III , Ramamurty V S Changalvala , John C. Drach , Ernest Randall Lanier, Jr. , Andrew Louis McIver , Bradley David Robertson , Dean Wallace Selleseth , Phiroze Behram Sethna , Leroy Townsend , Roy W. Ware
IPC: A01N43/04 , A61K31/70 , C07H19/14 , C07D239/70 , C07H19/16 , A61K31/7052 , A61K31/706 , A61K31/7064
Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.