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公开(公告)号：US20240295566A1
公开(公告)日：2024-09-05
申请号：US18169934
申请日：2023-02-16
Inventor： Zhaoxiang BIAN , Hoi Leong Xavier WONG , Lixiang ZHAI , Johnson Yiu-Nam LAU , Chengyuan LIN , Haitao XIAO
IPC: G01N33/68 , A61K31/40 , A61K31/44 , A61P3/00 , G01N33/569
CPC classification number: G01N33/6893 , A61K31/40 , A61K31/44 , A61P3/00 , G01N33/56911 , G01N2800/04
Abstract: Provided herein is a method of diagnosing a metabolic disorder in a subject involving determining the amount of at least one of Ruminococcus gnavus, phenethylamine, and tryptamine in a fecal sample obtained from the subject. Also provided is a method of treating a metabolic disorder in a subject in need thereof involving the administration of a therapeutically effective amount of a trace amine-associated receptor 1 inhibitor.
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公开(公告)号：US20240269211A1
公开(公告)日：2024-08-15
申请号：US18167842
申请日：2023-02-11
Inventor： Zhaoxiang BIAN , Chengyuan LIN , Haitao XIAO , Lixiang ZHAI , Hor Yue TAN
IPC: A61K36/344 , A61K36/076 , A61K36/284 , A61K36/40 , A61K36/484 , A61K36/718 , A61K36/74 , A61K36/898 , A61K36/9066 , A61P1/12
CPC classification number: A61K36/344 , A61K36/076 , A61K36/284 , A61K36/40 , A61K36/484 , A61K36/718 , A61K36/74 , A61K36/898 , A61K36/9066 , A61P1/12
Abstract: The present invention belongs to the technical field of pharmaceuticals, and particularly relates to a green and healthy medicine composition for preventing and treating inflammatory bowel disease. The medicine composition comprises: 15-25 g of roots of Codonopsis pilosula (Franch.) Nannf., 5-15 g of Atractylodes macrocephala Koidz., 15-25 g of Poria cocos (Schw.) Wolf, 1-10 g of Cornus officinalis Sieb. et Zucc., 1-10 g of Coptis chinensis Franch., 1-10 g of Curcuma Longa L., 5-15 g of Paederia scandens (Lour.) Merr., 5-15 g of Bletilla striata (Thunb.) Reichb.f., and 1-10 g of Glycyrrhiza uralensis Fisch. The solution disclosed by the present application has significant beneficial effect on the prevention and treatment of inflammatory bowel disease, and the herbs used in the present application are widely used traditional Chinese medicine products with no or low toxic effect; therefore, the green and healthy medicine composition has green, healthy and safe technical advantages.
