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公开(公告)号：US20240299622A1
公开(公告)日：2024-09-12
申请号：US18597085
申请日：2024-03-06
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Phillip MCCLELLAN , Ozan AKKUS , Michael MASTRAN , Subbakrishna SHANKAR
CPC classification number: A61L27/24 , A61L27/12 , A61L27/3687 , A61L27/3834 , A61L27/46 , A61L2300/64 , A61L2430/02 , A61L2430/10
Abstract: A biphasic osteotendinous repair scaffold is disclosed. The biphasic osteotendinous repair scaffold comprises a first phase comprising electrochemically aligned collagen (ELAC) threads and a calcium phosphate mineral and having a major surface. The biphasic osteotendinous repair scaffold also comprises a second phase comprising ELAC threads and having a major surface. The ELAC threads of the first phase are braided and crosslinked. The ELAC threads of the second phase are braided and crosslinked. The ELAC threads of the first and second phases form first and second interconnected macroporosities throughout the first and second phases, respectively. The calcium phosphate mineral of the first phase is distributed on the major surface of the first phase and within the interconnected macroporosity of the first phase. The second phase is adjacent to the first phase.
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公开(公告)号：US20180313762A1
公开(公告)日：2018-11-01
申请号：US16028998
申请日：2018-07-06
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Shan YANG
CPC classification number: G01N21/65 , G01J3/0205 , G01J3/0208 , G01J3/0224 , G01J3/0227 , G01J3/0235 , G01J3/0294 , G01J3/10 , G01J3/26 , G01J3/2823 , G01J3/44 , G01J3/4412 , G01J3/508 , G01N2201/06113
Abstract: A hyperspectral Raman imaging system having the ability to focus on excitation laser beam over a relatively wide field of view due to the use of a lens array, in particular a microlens array. Hyperspectral selection is provided in one embodiment through the use of dual-axis controlled dielectric filtration. Methods for analyzing materials with the system are disclosed. The device or system can be used in generally any application where investigation of materials is required.
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Patent Agency Ranking
公开(公告)号：US20180312988A1
公开(公告)日：2018-11-01
申请号：US16028926
申请日：2018-07-06
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Vipuil KISHORE , Mousa YOUNESI , Anowarul ISLAM
CPC classification number: C25D1/18 , A61L26/0033 , A61L27/24 , A61L27/26 , B05D1/18 , C07K14/78 , D01D5/0076 , D01F4/00
Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.
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公开(公告)号：US20230203692A1
公开(公告)日：2023-06-29
申请号：US18169365
申请日：2023-02-15
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Mousa YOUNESI , Umit Levent EROL
Abstract: A method for producing an electrocompacted and aligned strand is disclosed. The method includes the steps of: providing a channel having an anode on one side and a cathode on the other side separated by a non-conductive material to form an electrode; dispensing a solution comprising one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature into the channel to complete a circuit between the anode and the cathode; applying a DC current in the range of 1-200 volts to the electrode through the solution in the channel to form an electrocompacted and aligned strand; and transferring the aligned strand out of the electrode. The one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature can comprise collagen molecules that have different charges at different pH values. Materials including electrochemically aligned and compacted compounds are also disclosed.
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公开(公告)号：US20210228771A1
公开(公告)日：2021-07-29
申请号：US17158424
申请日：2021-01-26
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Adonis HIJAZ
Abstract: A biologic material is disclosed. The biologic material comprises a crosslinked structural protein and macrophages seeded on the crosslinked structural protein. A method of use of the biologic material for an immunoregenerative treatment in a patient in need thereof also is disclosed. The method comprises steps of: (1) seeding the macrophages on the crosslinked structural protein, thereby obtaining the biologic material; and (2) implanting the biologic material into the patient.
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公开(公告)号：US20210108321A1
公开(公告)日：2021-04-15
申请号：US16605859
申请日：2018-04-20
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Mousa YOUNESI , Umit Levent EROL
Abstract: Devices suitable for the production of electrochemically aligned materials such as strands, threads or fibers. The device includes a substantially horizontally aligned electrochemical cell in one embodiment, with the arrangement producing highly compacted materials. Materials including electrochemically aligned and compacted compounds are also disclosed, along with methods for making and using the materials.
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公开(公告)号：US20150376806A1
公开(公告)日：2015-12-31
申请号：US14766656
申请日：2014-02-11
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan AKKUS , Vipuil KISHORE , Mousa YOUNESI , Anowarul ISLAM
CPC classification number: C25D1/18 , A61L26/0033 , A61L27/24 , A61L27/26 , B05D1/18 , C07K14/78 , D01D5/0076 , D01F4/00
Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.
Abstract translation: 电化学排列和压实的分子，具有两性性质的纳米颗粒和微粒，例如胶原蛋白，弹性蛋白，角蛋白和带电的纳米颗粒材料，制备和使用材料以及相关生产相关装置的方法。 在一个实施例中，公开了一种用于生产连续电化学排列的线，线或纤维的装置。 在另一个实施方案中，公开了通过生物分子的3D电化学压实制备组成和几何复杂的解剖形式。 在另一个实施方案中，还公开了用于制造图案化晶格结构，特别是具有可控孔径和形态以及晶格结构本身的方法。
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