公开(公告)号：US20160069889A1

公开(公告)日：2016-03-10

申请号：US14652728

申请日：2013-12-19

Applicant: CARIS SCIENCE, INC.

Inventor： David SPETZLER ,  Valeriy DOMENYUK ,  Tassilo HORNUNG ,  Günter MAYER ,  Michael FAMULOK

IPC: G01N33/574 ,  G01N33/53 ,  C12N15/10

CPC classification number: G01N33/57488 ,  C12N15/1048 ,  C12Q1/6811 ,  C12Q1/6886 ,  G01N33/5076 ,  G01N33/5308 ,  C12Q2525/205

Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.

Abstract translation: 提供了从潜在的适配子序列库中选择特异于目的靶标的适体的方法。 所公开的适配子可用于检测和/或表征感兴趣的生物实体，例如， 微泡和/或表面抗原。 进一步公开的是可用于诊断不同类型癌症的不同疾病的生物标志物。