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公开(公告)号：US20140051692A1
公开(公告)日：2014-02-20
申请号：US13959268
申请日：2013-08-05
Applicant: Bristol-Myers Squibb Company
Inventor： B. Narasimhulu Naidu , Manoj Patel , Stanley D'Andrea , Zhizhen Barbara Zheng , Timothy P. Connolly , David R. Langley , Kevin Peese , Zhongyu Wang , Michael A. Walker , John F. Kadow
IPC: A61K31/5383 , A61K45/06 , C07D491/22 , C07D498/22 , A61K31/519
CPC classification number: A61K31/5383 , A61K31/519 , A61K45/06 , C07D487/16 , C07D491/22 , C07D498/16 , C07D498/22
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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公开(公告)号：US09006235B2
公开(公告)日：2015-04-14
申请号：US13782996
申请日：2013-03-01
Applicant: Bristol-Myers Squibb Company
Inventor： Zhizhen Barbara Zheng , Stanley D'Andrea , David R. Langley , B. Narasimhulu Naidu
IPC: A61K31/535 , A61K31/519 , C07D487/00 , C07D413/00 , C07D498/02 , C07D487/04 , A61K45/06 , C07F7/08 , A61K31/695
CPC classification number: C07D487/04 , A61K31/519 , A61K31/695 , A61K45/06 , C07F7/0812
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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Patent Agency Ranking
公开(公告)号：US20130237499A1
公开(公告)日：2013-09-12
申请号：US13782996
申请日：2013-03-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zhizhen Barbara Zheng , Stanley D'Andrea , David R. Langley , B. Narasimhulu Naidu
IPC: C07D487/04 , A61K31/695 , A61K31/519 , A61K45/06 , C07F7/08
CPC classification number: C07D487/04 , A61K31/519 , A61K31/695 , A61K45/06 , C07F7/0812
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US20130102589A1
公开(公告)日：2013-04-25
申请号：US13651538
申请日：2012-10-15
Applicant: Bristol-Myers Squibb Company
Inventor： Zhizhen Barbara Zheng , Stanley D'Andrea
IPC: C07D519/00 , A61P31/14 , A61K31/55
CPC classification number: C07D487/04
Abstract: The present invention provides (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Abstract translation: 本发明提供（1aR，12bS）-8-环己基-11-氟-N - （（1-甲基环丙基）磺酰基）-1a - （（3-甲基-3,8-二氮杂双环[3.2.1] - 基）羰基）-1,1a，2,12b-四氢环丙[d]吲哚并[2,1-a] [2]苯并氮杂-5-甲酰胺（式I），包括药学上可接受的盐，以及组合物和方法 使用该化合物。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US09034882B2
公开(公告)日：2015-05-19
申请号：US13782198
申请日：2013-03-01
Applicant: Bristol-Myers Squibb Company
Inventor： Annapurna Pendri , David R. Langley , Samuel Gerritz , Guo Li , Weixu Zhai , Stanley D'Andrea , Manoj Patel , B. Narasimhulu Naidu , Kevin Peese , Zhongyu Wang
IPC: A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D498/08 , C07D519/00
CPC classification number: C07D487/04 , C07D498/08 , C07D519/00
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US08906929B2
公开(公告)日：2014-12-09
申请号：US13959268
申请日：2013-08-05
Applicant: Bristol-Myers Squibb Company
Inventor： B. Narasimhulu Naidu , Manoj Patel , Stanley D'Andrea , Zhizhen Barbara Zheng , Timothy P. Connolly , David R. Langley , Kevin Peese , Zhongyu Wang , Michael A. Walker , John F. Kadow
IPC: C07D471/04 , C07D471/22 , C07D487/04 , A61K31/535 , A01N37/18 , A61K38/00 , A61P31/18 , C07D267/22 , C07D491/22 , A61K31/5383 , A61K31/519 , C07D498/16 , C07D487/16 , A61K45/06 , C07D498/22
CPC classification number: A61K31/5383 , A61K31/519 , A61K45/06 , C07D487/16 , C07D491/22 , C07D498/16 , C07D498/22
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US20130231331A1
公开(公告)日：2013-09-05
申请号：US13782198
申请日：2013-03-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Annapurna Pendri , David R. Langley , Samuel Gerritz , Guo Li , Weixu Zhai , Stanley D'Andrea , Manoj Patel , B. Narasimhulu Naidu , Kevin Peese , Zhongyu Wang
IPC: C07D487/04 , C07D498/08
CPC classification number: C07D487/04 , C07D498/08 , C07D519/00
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
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