公开(公告)号：US20160152580A1

公开(公告)日：2016-06-02

申请号：US14953854

申请日：2015-11-30

Applicant: BASF SE

Inventor： Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Christoph FLECKENSTEIN ,  Martin KALLER ,  Ulrik STENGEL ,  Mathieu BLANCHOT ,  Ritesh NAIR

IPC: C07D263/22

CPC classification number: C07D263/22 ,  C07D263/38

Abstract: The invention relates to a process for preparing heonone (meth)acrylate by transesterification of alkyl (meth)acrylate with heonone, which comprises the steps: (i) reaction of alkyl (meth)acrylate with heonone in the presence of a catalyst comprising titanium(IV) or zirconium(IV) and a stabilizer in the presence of an entrainer which forms an azeotrope with the alcohol bound in the alkyl (meth)acrylate, (ii) continuous removal by distillation of the azeotrope of entrainer and alcohol, with steps (i) and (ii) being carried out simultaneously until heonone has been essentially completely reacted, (iii) addition of water to the product mixture comprising heonone (meth)acrylate obtained in steps (i) and (ii) and removal of the hydrolyzate of the catalyst comprising titanium(IV) or zirconium(IV) by filtration, (iv) distillation of unreacted alkyl (meth)acrylate and entrainer from the product mixture, (v) distillation of water from the product mixture, with step (iv) also being able to be carried out before step (iii) and steps (iv) and (v) also being able to be carried out in a distillation step, wherein steps (i) and (ii) are carried out in the presence of an inorganic or organic acid.

Abstract translation: 本发明涉及一种通过（甲基）丙烯酸烷基酯与保护剂的酯交换制备苯乙烯（甲基）丙烯酸酯的方法，该方法包括以下步骤：（i）（甲基）丙烯酸烷基酯与保护剂在含钛的催化剂 IV）或锆（IV）和稳定剂，其在与（甲基）丙烯酸烷基酯中结合的醇形成共沸物的夹带剂存在下，（ii）通过蒸馏除去夹带剂和醇的共沸物， i）和（ii）同时进行直到恒酮基本上完全反应，（iii）向包含在步骤（i）和（ii）中获得的（甲基）丙烯酸氢醌的产物混合物中加入水，并除去水解产物 催化剂通过过滤包括钛（IV）或锆（IV），（iv）从产物混合物中蒸馏未反应的（甲基）丙烯酸烷基酯和夹带剂，（v）从产物混合物中蒸馏水，与步骤（iv） 能够成为 在步骤（iii）之前进行，步骤（iv）和（v）也可以在蒸馏步骤中进行，其中步骤（i）和（ii）在无机或有机酸的存在下进行。

公开(公告)号：US20160186220A1

公开(公告)日：2016-06-30

申请号：US14974267

申请日：2015-12-18

Applicant: BASF SE

Inventor： Christoph FLECKENSTEIN ,  Mathieu BLANCHOT ,  Benoit BLANK ,  Martin KALLER ,  Ulrik STENGEL ,  Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Ritesh NAIR

IPC: C12P17/04 ,  C09D133/14 ,  C08F220/28 ,  C07D307/46

CPC classification number: C12P17/04 ,  C07D307/46 ,  C08F220/28 ,  C08F2220/282 ,  C09D133/14

Abstract: The invention relates to a process for preparing a compound of the formula (I), in which R is H or C1-C6 alkyl, by reaction of at least one compound of the formula (II) in which R has the same definition as in the formula (I) and in which R1 is H, C1-C12 alkyl or C3-C12 cycloalkyl, with a compound of the formula (III) in which R2 is H or C(O)R3, in which R3 is H or C1-C12 alkyl, in the presence of at least one enzyme suitable for transesterification.

Abstract translation: 本发明涉及通过至少一种式（II）化合物（其中R的定义如下）的式（I）化合物的制备方法，其中R是H或C 1 -C 6烷基， 式（I），其中R 1为H，C 1 -C 12烷基或C 3 -C 12环烷基，与式（III）化合物（其中R 2为H或C（O）R 3），其中R 3为H或C 1 -C 12烷基，在至少一种适于酯交换的酶的存在下。

公开(公告)号：US20160090348A1

公开(公告)日：2016-03-31

申请号：US14854141

申请日：2015-09-15

Applicant: BASF SE

Inventor： Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Christoph FLECKENSTEIN ,  Martin KALLER ,  Ulrik STENGEL ,  Mathieu BLANCHOT ,  Ritesh NAIR

IPC: C07C67/03 ,  C07C67/48

CPC classification number: C07C67/03 ,  C07C69/54

Abstract: The invention relates to a process for preparing a C8-C24 alkyl(meth)acrylate by transesterification of methyl(meth)acrylate with a C8-C24 alkanol, said process comprising the steps of:(i) reacting methyl(meth)acrylate with the C8-C24 alkanol in the presence of a tin-comprising catalyst and a stabilizer in the presence of an entraining agent which forms an azeotrope with methanol,(ii) continuously distilling off the azeotrope of entraining agent and methanol wherein steps (i) and (ii) are carried out simultaneously until the C8-C24 alkanol has been substantially completely reacted,(iii) washing with an aqueous alkaline washing solution the C8-C24 alkyl (meth)acrylate-comprising product mixture obtained in steps (i) and (ii) to remove from the product mixture the tin-comprising catalyst and at least some of the stabilizer,(iv) distilling off unconverted methyl(meth)acrylate and entraining agent from the product mixture,(v) distilling off water from the product mixturewherein a product having a by-product content of

Abstract translation: 本发明涉及通过（甲基）丙烯酸甲酯与C8-C24链烷醇的酯交换制备C 8 -C 24烷基（甲基）丙烯酸酯的方法，所述方法包括以下步骤：（i）使（甲基）丙烯酸甲酯与 在含有催化剂和稳定剂的存在下，在与甲醇形成共沸物的夹带剂的存在下，（ⅱ）连续蒸馏出夹带剂和甲醇的共沸物，其中步骤（i）和（ ii）同时进行，直到C8-C24烷醇已经基本上完全反应，（iii）用碱性洗涤液将步骤（i）和（ii）中获得的（甲基）丙烯酸（甲基）丙烯酸烷基酯产物混合物 从产物混合物中除去含锡催化剂和至少一些稳定剂，（iv）从产物混合物中蒸馏未转化的（甲基）丙烯酸甲酯和夹带剂，（v）从产物混合物中蒸出水，其中 亲 在步骤（v）之后获得副产物含量<0.5重量％的管道，步骤（iii）之前也可以进行步骤（iv），步骤（iv）和（v））也可以在 一个蒸馏步骤。

公开(公告)号：US20200231528A1

公开(公告)日：2020-07-23

申请号：US16639174

申请日：2018-08-16

Applicant: BASF SE

Inventor： Mathieu BLANCHOT ,  Uwe MEISENBURG ,  Steffen MAURER ,  Jochen PETZOLDT ,  Tobias HOEFENER ,  Boris BREITSCHEIDEL ,  Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Martin KALLER ,  Christoph FLECKENSTEIN ,  Ulrik STENGEL ,  Ritesh NAIR

IPC: C07C67/24

Abstract: A process for preparing an ester of (meth)acrylic acid or a derivative thereof comprises reacting (meth)acrylic acid or a derivative thereof with glycerol carbonate at a reaction temperature of 10 to 150° C. without a solvent in the presence of at least one enzyme catalyzing the esterification reaction.

公开(公告)号：US20160251371A1

公开(公告)日：2016-09-01

申请号：US15054506

申请日：2016-02-26

Applicant: BASF SE

Inventor： Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Christoph FLECKENSTEIN ,  Martin KALLER ,  Ritesh NAIR ,  Ulrik STENGEL ,  Mathieu BLANCHOT

IPC: C07D493/04 ,  C09K8/42 ,  C09K8/44 ,  C08F22/20

CPC classification number: C07D493/04 ,  C08F22/20 ,  C09J4/00 ,  C09K8/426 ,  C09K8/44

Abstract: A process for preparing isosorbide di(meth)acrylate by transesterifying alkyl (meth)acrylate with isosorbide, comprising the steps of: (i) reacting alkyl (meth)acrylate with isosorbide in the presence of a catalyst comprising titanium(IV) or zirconium(IV) and a stabilizer in the presence of an azeotroping agent which forms an azeotrope with the alcohol bound in the alkyl (meth)acrylate, (ii) continuously distilling off the azeotrope of azeotroping agent and alcohol, wherein steps (i) and (ii) are conducted simultaneously until the isosorbide has been essentially fully converted, (iii) adding water to the product mixture which comprises isosorbide (meth)acrylate and is obtained in steps (i) and (ii) and removing the hydrolyzate of the catalyst comprising titanium(IV) or zirconium(IV), (iv) distilling unconverted alkyl (meth)acrylate and azeotroping agent out of the product mixture, (v) distilling off water from the product mixture, wherein step (iv) can also be conducted before step (iii) and steps (iv) and (v) can also be conducted in one distillation step.

Abstract translation: 包括以下步骤：（i）使（甲基）丙烯酸烷基酯与异山梨醇在含钛（Ⅳ）或锆（ⅰ）的催化剂的存在下反应来制备二（甲基）丙烯酸异山梨醇酯的方法， IV）和在与（甲基）丙烯酸烷基酯结合的醇形成共沸物的共沸剂存在下​​的稳定剂，（ii）连续蒸馏共沸剂和醇的共沸物，其中步骤（i）和（ii ）同时进行，直到异山梨醇基本上完全转化，（iii）向包含异山梨醇（甲基）丙烯酸酯并在步骤（i）和（ii）中获得的产物混合物中加入水，并除去包含钛的催化剂的水解产物 （IV）或锆（IV），（iv）从产物混合物中蒸馏未转化的（甲基）丙烯酸烷基酯和共沸剂，（v）从产物混合物中蒸馏除去水，其中步骤（iv）也可以在步骤 （ii i）和步骤（iv）和（v）也可以在一个蒸馏步骤中进行。

公开(公告)号：US20160251370A1

公开(公告)日：2016-09-01

申请号：US15051974

申请日：2016-02-24

Applicant: BASF SE

Inventor： Andrea MISSKE ,  Friederike FLEISCHHAKER ,  Christoph FLECKENSTEIN ,  Martin KALLER ,  Ulrik STENGEL ,  Mathieu BLANCHOT ,  Claudia STOER ,  Ritesh NAIR

IPC: C07D493/04

CPC classification number: C07D493/04 ,  C08F222/1006 ,  C09J4/00 ,  C09J4/06

Abstract: A process for preparing isosorbide ethoxylate di(meth)acrylate by transesterifying alkyl (meth)acrylate with isosorbide ethoxylate, comprising the steps of: (i) ethoxylating isosorbide to give isosorbide ethoxylate, (ii) reacting alkyl (meth)acrylate with isosorbide ethoxylate in the presence of potassium phosphate as catalyst and a stabilizer and in the presence of an azeotroping agent which forms an azeotrope with the alcohol bound in the alkyl (meth)acrylate, (iii) continuously distilling off the azeotrope of azeotroping agent and alcohol, wherein steps (ii) and (iii) are conducted simultaneously until the isosorbide ethoxylate has been essentially fully converted, (iv) removing the catalyst from the product mixture comprising isosorbide ethoxylate di(meth)acrylate, (v) distilling unconverted alkyl (meth)acrylate and azeotroping agent out of the product mixture.

Abstract translation: 包括以下步骤：（i）乙氧基化异山梨醇，得到异山梨醇乙氧基化物，（ii）使（甲基）丙烯酸烷基酯与异山梨醇乙氧基化物反应，得到异山梨醇乙氧基化物 在与（甲基）丙烯酸烷基酯结合的醇形成共沸物的共沸物存在下，连续蒸馏共沸剂和醇的共沸物，其中步骤 （ii）和（iii）同时进行，直到异山梨醇乙氧基化物已经基本上完全转化，（iv）从包含异山梨醇乙氧基化物二（甲基）丙烯酸酯的产物混合物中除去催化剂，（v）蒸馏未转化的（甲基） 共沸剂排出产品混合物。