公开(公告)号：US11716427B2

公开(公告)日：2023-08-01

申请号：US16640114

申请日：2018-09-05

Applicant: Arrayjet Limited

Inventor： Benjamin Mitchell

IPC: H04N1/024 ,  H04N1/00 ,  G06K15/10

CPC classification number: H04N1/0005 ,  G06K15/10 ,  G06K15/105 ,  H04N1/00082 ,  H04N1/00997 ,  H04N1/02418 ,  H04N1/02463

Abstract: A microarrayer for dispensing reagent onto a substrate, comprising a dispensing print head adapted to load reagent and provided with a plurality of nozzles to dispense said at least reagent on the substrate, wherein the print head is mounted in the microarrayer to allow the print head to move with respect to the substrate in subsequent, essentially, parallel print passes, wherein the print head moves during a first print pass between a first end of the substrate toward a second end of the substrate and during a subsequent printpass in the opposite direction, the microarrayer being characterised in that the microarrayer comprises a first camera adapted to move behind the print head during a print pass and a second camera adapted to move ahead of the print head during said print pass, the first and second camera being adapted to obtain images of the substrate.

公开(公告)号：US11052370B2

公开(公告)日：2021-07-06

申请号：US16640028

申请日：2018-09-05

Applicant: Arrayjet Limited

Inventor： Benjamin Mitchell ,  Joan Salvatella Serra

IPC: B01J19/00 ,  B01L3/00 ,  B41M5/00 ,  G01N21/956 ,  G01N21/84

Abstract: Method for manufacturing microarrays and verifying the quality of said microarrays, wherein the method comprises: a) providing at least one reagent, b) loading said at least one reagent in a dispensing print head, in a predetermined arrangement, c) in a first print pass, generating instructions for the print head and moving said print head with respect to a substrate to print said at least one reagent on the substrate to obtain microarrays, d) obtaining an image of the printed microarrays by means of a camera, e) processing the obtained images of the printed microarrays, to calculate parameters indicative for the quality of the printed microarrays, f) comparing, at the end of the first print pass, the calculated parameters for the printed microarrays with predetermined criteria for the microarrays, to identify possible printing defects, g) comparing, for the printed microarrays, the identified printing defects of step f), h) using the outcome of the comparison of step g) to select a corrective action to improve the quality of the microarrays, prior to the printing of a subsequent print pass.

公开(公告)号：US11691433B2

公开(公告)日：2023-07-04

申请号：US16640029

申请日：2018-09-05

Applicant: Arrayjet Limited

Inventor： Benjamin Mitchell ,  Joan Salvatella Serra ,  Marisa Chong-Kwan

IPC: B41J2/21 ,  B01J19/00 ,  G01N21/88 ,  G06T7/00 ,  G01N21/956 ,  B01L3/00

CPC classification number: B41J2/2142 ,  B01J19/0046 ,  B01L3/502715 ,  G01N21/8806 ,  G01N21/956 ,  G06T7/0002 ,  B01J2219/00378 ,  B01J2219/00693

Abstract: Method for manufacturing a microarray and verifying the quality of said microarray, wherein the method comprises: —providing at least one reagent, —loading said at least one reagent in a dispensing print head, in a predetermined arrangement, —moving the print head with respect to a substrate and dispensing said at least one reagent on the substrate, during a print pass, to obtain a microarray, —illuminating the substrate using illumination means and obtaining an image of the printed microarray on the substrate, using a camera, —processing the obtained image to verify the quality of the microarray, wherein the step of obtaining an image of the printed microarray comprises: —illuminating the substrate and obtaining an image of the microarray by means of illumination means and a camera which are connected to and move together with the print head with respect to the substrate, the illumination means and the camera being adapted to move behind the print head.