公开(公告)号：US20160175361A1

公开(公告)日：2016-06-23

申请号：US14489415

申请日：2014-09-17

Applicant: Advanced Cell Technology, Inc.

Inventor： Robert P. Lanza ,  Shi-Jiang Lu ,  Wei Wang

IPC: A61K35/30 ,  C12N5/0793

CPC classification number: A61K35/30 ,  A61K35/545 ,  C12N5/062 ,  C12N5/0623 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  Y02A50/473

Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.

公开(公告)号：US09763984B2

公开(公告)日：2017-09-19

申请号：US14138008

申请日：2013-12-21

Applicant: Advanced Cell Technology, Inc.

Inventor： Qiang Feng ,  Shi-Jiang Lu ,  Robert P. Lanza

IPC: A61K35/19 ,  C12N5/078

CPC classification number: A61K35/19 ,  C12N5/0644 ,  C12N2501/04 ,  C12N2501/20 ,  C12N2501/2306 ,  C12N2501/2309 ,  C12N2501/2311 ,  C12N2501/30 ,  C12N2501/40 ,  C12N2501/727 ,  C12N2501/734 ,  C12N2501/91 ,  C12N2506/11 ,  Y02A50/411

Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

公开(公告)号：US20140294778A1

公开(公告)日：2014-10-02

申请号：US14214598

申请日：2014-03-14

Applicant: Advanced Cell Technology, Inc.

Inventor： Robert P. Lanza ,  Shi-Jiang Lu ,  Wei Wang

IPC: A61K35/30 ,  C12N5/079 ,  C12N5/0797

CPC classification number: A61K35/545 ,  A61K35/30 ,  C12N5/0606 ,  C12N5/062 ,  C12N5/0623 ,  C12N5/0696 ,  C12N2500/33 ,  C12N2501/105 ,  C12N2501/13 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2506/02

Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.

Abstract translation: 提供了用于从多能干细胞产生感光细胞和感光祖细胞的方法。 另外提供感光细胞和感光细胞的组合物，以及其治疗用途的方法。 示例性的方法可以产生感光细胞和/或感光细胞的基本上纯的培养物。

公开(公告)号：US20140271590A1

公开(公告)日：2014-09-18

申请号：US14138008

申请日：2013-12-21

Applicant: Advanced Cell Technology, Inc.

Inventor： Qiang Feng ,  Shi-Jiang Lu ,  Robert P. Lanza

IPC: A61K35/14

CPC classification number: A61K35/19 ,  C12N5/0644 ,  C12N2501/04 ,  C12N2501/20 ,  C12N2501/2306 ,  C12N2501/2309 ,  C12N2501/2311 ,  C12N2501/30 ,  C12N2501/40 ,  C12N2501/727 ,  C12N2501/734 ,  C12N2501/91 ,  C12N2506/11 ,  Y02A50/411

Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

Abstract translation: 提供了从多能干细胞（例如人胚胎干细胞（hESC））和诱导的多能干细胞（iPSCs）产生血小板的方法。 这些方法可以在不形成胚状体或多能干细胞簇的情况下进行，并且可以在不使用间质诱导细胞的情况下进行。 此外，产量和/或纯度可以大于从多能干细胞产生血小板的现有方法报道的产率和/或纯度。 还提供了包含血小板的组合物和药物制剂，优选由多能干细胞产生。

公开(公告)号：US20140370007A1

公开(公告)日：2014-12-18

申请号：US14362775

申请日：2012-12-06

Applicant: Advanced Cell Technology, Inc.

Inventor： Kathryn L. McCabe ,  Shi-Jiang Lu ,  Robert P. Lanza

IPC: C12N5/079 ,  A61K9/00 ,  C12N5/0797 ,  A61K35/30 ,  A61K45/06

CPC classification number: C12N5/0621 ,  A61K9/0048 ,  A61K35/30 ,  A61K45/06 ,  A61L27/3808 ,  A61L27/3839 ,  A61L27/3895 ,  A61L2430/16 ,  C12N5/0623 ,  C12N2500/60 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2506/45 ,  C12N2533/50

Abstract: This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more “youthful” gene expression relative to cells obtained from donated tissue.

Abstract translation: 本公开一般涉及用于治疗视觉障碍（包括角膜疾病）的基于细胞的疗法。 方法用于角膜细胞与干细胞的定向分化。 还提供了角膜内皮细胞的组合物及其用途。 示例性组合物相对于从捐赠组织获得的细胞，显示改善的细胞密度和/或更“年轻”的基因表达。