公开(公告)号：US08961956B2

公开(公告)日：2015-02-24

申请号：US13905526

申请日：2013-05-30

Applicant: Advanced Cell Technology, Inc.

Inventor： Erin Anne Kimbrel ,  Robert Lanza ,  Jianlin Chu ,  Nicholas Arthur Kouris

IPC: A61K35/12 ,  A61K35/28 ,  A61K48/00 ,  C12N5/0789 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K45/06 ,  A61K48/00 ,  C12N5/0647 ,  C12N5/0662 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2506/02 ,  C12N2506/11 ,  C12N2533/90

Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

Abstract translation: 本发明一般涉及衍生自成血成血管细胞的间充质基质细胞（MSC）的新制剂，获得这样的MSC的方法，以及使用这种MSC治疗病理学的方法。 本发明的方法产生大量具有保留能量的年轻表型的MSC，其可用于治疗病理学。

公开(公告)号：US20160038543A1

公开(公告)日：2016-02-11

申请号：US14504351

申请日：2014-10-01

Applicant: Advanced Cell Technology, Inc.

Inventor： Erin Anne Kimbrel ,  Robert P. Lanza ,  Jianlin Chu ,  Nicholas Arthur Kouris

IPC: A61K35/28 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407 ,  C12N5/0647 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2502/1171 ,  C12N2506/02 ,  C12N2506/11 ,  C12N2506/28 ,  C12N2533/54 ,  A61K2300/00

Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

公开(公告)号：US08962321B2

公开(公告)日：2015-02-24

申请号：US13691349

申请日：2012-11-30

Applicant: Advanced Cell Technology, Inc.

Inventor： Erin Anne Kimbrel ,  Robert Lanza ,  Jianlin Chu ,  Nicholas Arthur Kouris

IPC: C12N5/00 ,  C12N5/077 ,  A61K48/00 ,  A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407

CPC classification number: A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407 ,  A61K48/00 ,  C12N5/0647 ,  C12N5/0652 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2502/1171 ,  C12N2506/02 ,  C12N2506/11 ,  C12N2506/28 ,  C12N2533/54 ,  A61K2300/00

Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.