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公开(公告)号：US20250025583A1
公开(公告)日：2025-01-23
申请号：US18597037
申请日：2024-03-06
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Stefano Buono , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maribel Lopera-Sierra , Maurizio Mariani , Giovanni Tesoriere
Abstract: The present invention relates to methods of treating cancers that overexpress somatostatin receptors, e.g. neuroendocrine tumors (NET). In particular, the invention provides novel therapies based on the combination of a peptide receptor radionuclide therapeutic (PRRT) agent and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR angonists, TGF-β inhibitors, IL15/IL-15RA complex, and selected PD-1 inhibitors.
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公开(公告)号：US20210379213A1
公开(公告)日：2021-12-09
申请号：US17209122
申请日：2021-03-22
Applicant: Advanced Accelerator Applications SA
Inventor： Francesco de Palo , Lorenza Fugazza , Donato Barbato , Maurizio Mariani , Daniela Chicco , Giovanni Tesoriere , Clementina Brambati
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US12151003B2
公开(公告)日：2024-11-26
申请号：US18640884
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US12144873B2
公开(公告)日：2024-11-19
申请号：US18640891
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20240285813A1
公开(公告)日：2024-08-29
申请号：US18640907
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
CPC classification number: A61K51/048 , A61K33/24 , C22B59/00 , A61K51/0482
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20210379212A1
公开(公告)日：2021-12-09
申请号：US17209121
申请日：2021-03-22
Applicant: ADVANCED ACCELERATOR APPLICATIONS SA
Inventor： Francesco de Palo , Lorenza Fugazza , Donato Barbato , Maurizio Mariani , Daniela Chicco , Giovanni Tesoriere , Clementina Brambati
IPC: A61K51/08
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20240285814A1
公开(公告)日：2024-08-29
申请号：US18640917
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
CPC classification number: A61K51/048 , A61K33/24 , C22B59/00 , A61K51/0482
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20240285812A1
公开(公告)日：2024-08-29
申请号：US18640891
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
CPC classification number: A61K51/048 , A61K33/24 , C22B59/00 , A61K51/0482
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20240285811A1
公开(公告)日：2024-08-29
申请号：US18640884
申请日：2024-04-19
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
CPC classification number: A61K51/048 , A61K33/24 , C22B59/00 , A61K51/0482
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
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公开(公告)号：US20250049969A1
公开(公告)日：2025-02-13
申请号：US18927034
申请日：2024-10-25
Applicant: Advanced Accelerator Applications SA
Inventor： Donato Barbato , Clementina Brambati , Daniela Chicco , Francesco de Palo , Lorenza Fugazza , Maurizio Mariani , Giovanni Tesoriere
Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
