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公开(公告)号：US20230278989A1
公开(公告)日：2023-09-07
申请号：US18159452
申请日：2023-01-25
Inventor： Steven HOWARD , Benjamin David CONS , Jeffrey David ST. DENIS , Charlotte Mary GRIFFITHS-JONES , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Alan Richard BURNS , David COUSIN , Hannah Louise DEXTER , Guillaume François PARRA , John Paul WATTS , Robert JEWELL , Jennifer Ann STOCKWELL , Kim Louise HIRST , Isabelle Anne LEMASSON , David John NASH , James Daniel OSBORNE , Jonas Calleja PRIEDE , Nicholas Paul RICHARDS , Aaron Michael DUMAS , Brian Christopher BISHOP , David PARRY-JONES , Jeremy Peter SCOTT , Meenakshi Sundaram SHANMUGHAM , Peter Richard MULLENS , David Charles LATHBURY , Darren James DIXON , Matthew James GAUNT
IPC: C07D405/06
CPC classification number: C07D405/06 , C07B2200/13
Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US20200079761A1
公开(公告)日：2020-03-12
申请号：US16535931
申请日：2019-08-08
Inventor： Gianni CHESSARI , Steven HOWARD , lldiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mantyla NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00 , C07D413/06 , C07D403/12 , C07F9/572
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20210276984A1
公开(公告)日：2021-09-09
申请号：US17164045
申请日：2021-02-01
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20250074900A1
公开(公告)日：2025-03-06
申请号：US18785847
申请日：2024-07-26
Inventor： Steven HOWARD , Benjamin David CONS , Jeffrey David ST. DENIS , Charlotte Mary GRIFFITHS-JONES , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Alan Richard BURNS , David COUSIN , Hannah Louise DEXTER , Guillaume François PARRA , John Paul WATTS , Robert JEWELL , Jennifer Ann STOCKWELL , Kim Louise HIRST , Isabelle Anne LEMASSON , David John NASH , James Daniel OSBORNE , Jonas Calleja PRIEDE , Nicholas Paul RICHARDS , Aaron Michael DUMAS , Brian Christopher BISHOP , David PARRY-JONES , Jeremy Peter SCOTT , Meenakshi Sundaram SHANMUGHAM , Peter Richard MULLENS , David Charles LATHBURY , Darren James DIXON , Matthew James GAUNT
IPC: C07D405/06
Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US20250092027A1
公开(公告)日：2025-03-20
申请号：US18767400
申请日：2024-07-09
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20210101887A1
公开(公告)日：2021-04-08
申请号：US16498207
申请日：2018-03-28
Inventor： Steven HOWARD , Benjamin David CONS , Jeffrey David ST. DENIS , Charlotte Mary GRIFFITHS-JONES , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Alan Richard BURNS , David COUSIN , Hannah Louise DEXTER , Guillaume François PARRA , John Paul WATTS , Robert JEWELL , Jennifer Ann STOCKWELL , Kim Louise HIRST , Isabelle Anne LEMASSON , David John NASH , James Daniel OSBORNE , Jonas Calleja PRIEDE , Nicholas Paul RICHARDS , Aaron Michael DUMAS , Brian Christopher BISHOP , David PARRY-JONES , Jeremy Peter SCOTT , Meenakshi Sundaram SHANMUGHAM , Peter Richard MULLENS , David Charles LATHBURY , Darren James DIXON , Matthew James GAUNT
IPC: C07D405/06
Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
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公开(公告)号：US20220106287A1
公开(公告)日：2022-04-07
申请号：US17228151
申请日：2021-04-12
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D401/06 , A61K31/4439 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D403/06 , C07D409/14 , C07D487/08 , A61K31/496 , A61K31/501 , C07D413/14 , A61K45/06 , C07D403/14 , C07D407/14 , C07D417/14 , A61K31/444 , C07D401/14 , A61K31/506 , A61P35/00 , C07B59/00 , A61K31/4545
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20200247789A2
公开(公告)日：2020-08-06
申请号：US16535931
申请日：2019-08-08
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00 , C07D413/06 , C07D403/12 , C07F9/572
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20190055215A1
公开(公告)日：2019-02-21
申请号：US15763724
申请日：2016-09-29
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST.DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D401/06 , A61K31/4439 , A61K45/06 , C07D403/06 , A61K31/501 , A61K31/506 , C07D401/14 , C07D409/14 , A61K31/496 , C07D407/14 , A61K31/444 , A61K31/4545 , A61K31/5377 , C07D417/14 , A61P35/00
CPC classification number: C07D401/06 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20190016708A1
公开(公告)日：2019-01-17
申请号：US15763698
申请日：2016-09-29
Inventor： Gianni CHESSARI , Steven HOWARD , IIdiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Sarah CULLY , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D413/12 , C07D405/12 , C07D403/06 , A61P35/00 , C07D209/48
CPC classification number: C07D405/14 , A61P35/00 , C07B2200/05 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/5728
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
