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公开(公告)号:US20250025468A1
公开(公告)日:2025-01-23
申请号:US18906967
申请日:2024-10-04
Applicant: ARIBIO CO., LTD. , SK CHEMICALS CO., LTD.
Inventor: Jai Jun Choung , Yoon Pyo Choi , Byungwoo Kang , Fred Kim , Mi Sun Choung
IPC: A61K31/519 , A61K31/4985 , A61K31/506 , A61K31/522 , A61K31/53 , A61P25/28
Abstract: The present invention provides methods for reducing amyloid beta formation and for treating diseases associated with the accumulation of amyloid beta. The present invention provides (1) A β aggregation inhibition by A β Oligomer/Fibril formation inhibition, (2) BACE-1 reduction through β-Amyloidogenic Processing inhibition, (3) increased cerebral blood flow, (4) activation of Neuronal cell Death inhibition and Neurogenesis, Synaptogenesis, Angiogenesis promotion, (5) DKK-1 inhibition by Wnt Signaling and Aβ production Positive Feedback Loop for inhibition of APP to suppress Aβ accumulation, (6) Autophagy activation by cells, by providing Mirodenafil, Sildenafil, Vardenafil, Tadalafil, Udenafil, Dasantafil, and Avanafil and a Pharmaceutically Acceptable Salt, Solvate, and Hydrate in selected compounds key of ingredient containing drug compound composition, and this with the treatment method provided.