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公开(公告)号：US20240368128A1
公开(公告)日：2024-11-07
申请号：US18144004
申请日：2023-05-05
Applicant: ALIGOS THERAPEUTICS, INC.
IPC: C07D403/12 , A61P3/06 , A61P5/14
Abstract: Disclosed herein are methods of modulating the activity of a thyroid hormone receptor beta and methods of treating disease using a pyridazinone compound.
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公开(公告)号：US11858913B2
公开(公告)日：2024-01-02
申请号：US17520176
申请日：2021-11-05
Applicant: ALIGOS THERAPEUTICS, INC.
Inventor： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC: C07D401/14 , C07D403/12
CPC classification number: C07D403/12 , C07D401/14
Abstract: Disclosed herein are compounds of Formula I:
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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公开(公告)号：US11786532B2
公开(公告)日：2023-10-17
申请号：US17520173
申请日：2021-11-05
Applicant: ALIGOS THERAPEUTICS, INC.
Inventor： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC: A61K31/53 , A61P1/16 , A61P3/04 , A61K31/4439 , A61K45/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04
CPC classification number: A61K31/53 , A61K31/4439 , A61K45/06 , A61P1/16 , A61P3/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04
Abstract: Disclosed herein are compounds of Formula I″:
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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公开(公告)号：US20240199647A1
公开(公告)日：2024-06-20
申请号：US18499941
申请日：2023-11-01
Applicant: Aligos Therapeutics, Inc. , Katholieke Universiteit Leuven
Inventor： Dorothée Alice Marie-Eve Bardiot , Sandro Boland , Arnaud Didier Marie Marchand , Koen Vandyck , David McGowan , Leonid Beigelman , Antitsa Dimitrova Stoycheva
IPC: C07D513/10 , A61K45/06 , A61P31/14 , C07D471/10 , C07D487/10 , C07D487/20 , C07D498/10 , C07D498/20
CPC classification number: C07D513/10 , A61K45/06 , A61P31/14 , C07D471/10 , C07D487/10 , C07D487/20 , C07D498/10 , C07D498/20
Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11793815B2
公开(公告)日：2023-10-24
申请号：US17520168
申请日：2021-11-05
Applicant: ALIGOS THERAPEUTICS, INC.
Inventor： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC: C07D471/04 , A61K31/4245 , A61K31/53 , A61P1/16 , A61P3/04 , A61K31/404 , A61K31/437 , A61K31/451 , A61K31/46 , A61K31/506 , A61K31/575 , C07D209/46 , C07D209/96 , C07D403/12 , C07D413/12
CPC classification number: A61K31/53 , A61K31/404 , A61K31/4245 , A61K31/437 , A61K31/451 , A61K31/46 , A61K31/506 , A61K31/575 , A61P1/16 , A61P3/04 , C07D209/46 , C07D209/96 , C07D403/12 , C07D413/12 , C07D471/04
Abstract: Disclosed herein are compounds of Formula I′:
or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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公开(公告)号：US20230140238A1
公开(公告)日：2023-05-04
申请号：US17932218
申请日：2022-09-14
Applicant: Aligos Therapeutics, Inc. , Katholieke Universiteit Leuven
Inventor： Dorothée Alice Marie-Eve Bardiot , Koen Vandyck , Sandro Boland , Antitsa Dimitrova Stoycheva , Arnaud Didier Marie Marchand , Pierre Jean-Marie Bernard Raboisson , Leonid Beigelman
IPC: C07D401/14 , C07D409/14 , C07D417/14 , C07D405/14 , C07D401/12 , C07D487/04
Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220144811A1
公开(公告)日：2022-05-12
申请号：US17520176
申请日：2021-11-05
Applicant: ALIGOS THERAPEUTICS, INC.
Inventor： David Craig McGowan , Pierre Jean-Marie Bernard Raboisson , Koen Vandyck , Jerome Deval , Leonid Beigelman
IPC: C07D403/12 , C07D401/14
Abstract: Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
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公开(公告)号：US20220009924A1
公开(公告)日：2022-01-13
申请号：US17370623
申请日：2021-07-08
Applicant: ALIGOS THERAPEUTICS, INC.
IPC: C07D471/04 , A61K45/06 , A61P1/16
Abstract: Disclosed herein are compounds of Formula I′: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.
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公开(公告)号：US12180192B2
公开(公告)日：2024-12-31
申请号：US17330232
申请日：2021-05-25
Applicant: ALIGOS THERAPEUTICS, INC.
Inventor： Koen Vandyck , Pierre Jean-Marie Bernard Raboisson , David McGowan , Jerome Deval
IPC: C07D403/10 , C07D401/10 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
Abstract: Disclosed herein are compounds of Formula I: TL-La-CE-HD (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
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公开(公告)号：US12065428B2
公开(公告)日：2024-08-20
申请号：US17932218
申请日：2022-09-14
Applicant: Aligos Therapeutics, Inc. , Katholieke Universiteit Leuven
Inventor： Dorothée Alice Marie-Eve Bardiot , Koen Vandyck , Sandro Boland , Antitsa Dimitrova Stoycheva , Arnaud Didier Marie Marchand , Pierre Jean-Marie Bernard Raboisson , Leonid Beigelman
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04
Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
