公开(公告)号：US20160022736A1

公开(公告)日：2016-01-28

申请号：US14515619

申请日：2014-10-16

Applicant: ADVANCED CELL TECHNOLOGY, INC.

Inventor： QIANG FENG ,  SHI-JIANG LU ,  ROBERT P. LANZA

IPC: A61K35/19 ,  C12N5/078

CPC classification number: A61K35/19 ,  C12N5/0644 ,  C12N2501/04 ,  C12N2501/20 ,  C12N2501/2306 ,  C12N2501/2309 ,  C12N2501/2311 ,  C12N2501/30 ,  C12N2501/40 ,  C12N2501/727 ,  C12N2501/734 ,  C12N2501/91 ,  C12N2506/11 ,  Y02A50/411

Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.