公开(公告)号：US20140148592A1

公开(公告)日：2014-05-29

申请号：US14171305

申请日：2014-02-03

Applicant: A. Stewart CAMPBELL ,  Gregory LOHMAN ,  Obadiah J. PLANTE

Inventor： A. Stewart CAMPBELL ,  Gregory LOHMAN ,  Obadiah J. PLANTE

IPC: C07H3/06

CPC classification number: A61K39/1045 ,  A61K2039/6081 ,  C07H3/06 ,  C07H15/04 ,  C07H15/26 ,  C07K16/1203 ,  C07K19/00 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/21 ,  G01N33/56911 ,  G01N2333/212

Abstract: The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.

Abstract translation: 本发明提供合成的莫拉卡氏菌属低密度脂多糖（LOS）基寡糖和含有各种卡他莫拉胺血清型特异性寡糖抗原或各种核心卡他莫拉低聚糖结构或缀合物的缀合物，其对应于三种主要血清型和/或成员中的一种或多种 在给定的血清型。 寡糖可以通过依靠有限数量的单糖和二糖结构单元的化学组装方法来合成。 本发明进一步提供基于粘膜炎的基于LOS的免疫原性和免疫保护组合物及其衍生的抗体用于诊断，治疗和预防卡他莫拉菌引起的感染。