公开(公告)号：US20220324942A1

公开(公告)日：2022-10-13

申请号：US17608743

申请日：2020-05-07

Applicant: 2SEVENTY BIO, INC. ,  INHIBRX, INC.

Inventor： JORDAN JARJOUR ,  MARK POGSON ,  WAI-HANG LEUNG ,  KYLE JONES ,  WILLIAM CRAGO ,  ANGELICA SANABRIA ,  ANDREW HOLLANDS ,  JACOB GANO ,  MILTON MA ,  JOHN C. TIMMER ,  BRENDAN P. ECKELMAN

IPC: C07K14/705 ,  C07K14/73 ,  C07K14/725 ,  C07K16/28 ,  C12N9/90 ,  C07K14/715 ,  C07K14/005 ,  C12N15/86 ,  A61K35/17 ,  A61P35/00

Abstract: The present disclosure provides improved CD33 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.