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1.发明授权公开(公告)号：US07074837B2
公开(公告)日：2006-07-11
申请号：US10344272
申请日：2001-08-07
Applicant: Keiji Nakayama , Makoto Muto , Tatsuru Saito , Yuichiro Tani , Toshifumi Akiba
Inventor： Keiji Nakayama , Makoto Muto , Tatsuru Saito , Yuichiro Tani , Toshifumi Akiba
IPC: A61K31/357 , A61K31/11 , C07D317/14 , C07D319/06 , C07C47/11
CPC classification number: C07D209/54
Abstract: A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.
Abstract translation: 通过化合物（I）或化合物（X）制备作为合成抗生素化合物合成原料的中间体化合物（Ⅶ），化合物（Ⅷ）和化合物（ⅩⅣ）的方法，然后，化合物（Ⅱ） 各化合物如下所示; 和可用于制备的新化合物。
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2.发明申请
公开(公告)号：US20050272797A1
公开(公告)日：2005-12-08
申请号：US11197553
申请日：2005-08-05
Applicant: Keiji Nakayama , Makoto Muto , Tatsuru Saito , Yuichiro Tani , Toshifumi Akiba
Inventor： Keiji Nakayama , Makoto Muto , Tatsuru Saito , Yuichiro Tani , Toshifumi Akiba
IPC: C07D209/54 , C07D209/96 , A61K31/403
CPC classification number: C07D209/54
Abstract: A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.
Abstract translation: 通过化合物（I）或化合物（X）制备作为合成抗生素化合物合成原料的中间体化合物（Ⅶ），化合物（Ⅷ）和化合物（ⅩⅣ）的方法，然后，化合物（Ⅱ） 各化合物如下所示; 和可用于制备的新化合物。
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公开(公告)号：US20070197836A1
公开(公告)日：2007-08-23
申请号：US10593200
申请日：2005-03-25
Applicant: Kenichi Koyakumaru , Tatsuhiko Hayashibara , Toshifumi Akiba , Tatsuru Saito
Inventor： Kenichi Koyakumaru , Tatsuhiko Hayashibara , Toshifumi Akiba , Tatsuru Saito
IPC: C07C47/14
CPC classification number: C07C47/277 , C07C45/59 , C07C45/60
Abstract: The present invention provides a method for industrially advantageously producing a halogenated unsaturated carbonyl compound without environment problems. A production method of a halogenated unsaturated carbonyl compound represented by the formula (III) is provided, which includes reacting an alkoxy-cyclic ether represented by the formula (I) with an acid halide represented by the formula (II) wherein each symbol is as defined in the specification.
Abstract translation: 本发明提供了一种在没有环境问题的情况下工业上有利地制备卤代不饱和羰基化合物的方法。 提供由式（III）表示的卤代不饱和羰基化合物的制备方法，其包括使由式（I）表示的烷氧基 - 环醚与式（II）表示的酰卤反应，其中每个符号为 在规范中定义。
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4.发明授权
公开(公告)号：US06825353B2
公开(公告)日：2004-11-30
申请号：US10204550
申请日：2002-08-22
Applicant: Tatsuru Saito , Toshiaki Jouno , Yuichiro Tani , Toshifumi Akiba
Inventor： Tatsuru Saito , Toshiaki Jouno , Yuichiro Tani , Toshifumi Akiba
IPC: C07D21556
CPC classification number: C07D215/56 , A01N43/42 , A61K31/47 , A61K31/4709 , C07D401/04
Abstract: This invention relates to methods for the efficient production of quinolonecarboxylic acid based synthetic antibacterial agents which are expected for applications such as excellent medicaments and agricultural chemicals and to intermediate compounds to be used therein. According to the present invention, an amine substituent as the 7-position substituent of the quinolonecarboxylic acid derivative can be efficiently introduced.
Abstract translation: 本发明涉及有效生产喹诺酮羧酸的合成抗菌剂的方法，其预期用于优异的药物和农用化学品以及其中使用的中间体化合物。 根据本发明，可以有效地引入作为喹诺酮羧酸衍生物的7-位取代基的胺取代基。
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5.发明申请Process for producing cyclopropane monoacetal derivative and intermediate therefor 失效制备环丙烷单缩醛衍生物及其中间体的方法
公开(公告)号：US20070191643A1
公开(公告)日：2007-08-16
申请号：US10593129
申请日：2005-03-25
Applicant: Kenichi Koyakumaru , Shingo Ueyama , Katsuji Ujita , Tatsuhiko Hayashibara , Naoshi Nakagawa , Toshifumi Akiba , Tatsuru Saito
Inventor： Kenichi Koyakumaru , Shingo Ueyama , Katsuji Ujita , Tatsuhiko Hayashibara , Naoshi Nakagawa , Toshifumi Akiba , Tatsuru Saito
IPC: C07C49/04 , C07C49/227 , C07C49/20
CPC classification number: C07C45/59 , C07C45/65 , C07C45/70 , C07C47/277 , C07C47/37 , C07C2601/02
Abstract: A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.
Abstract translation: 工业上有利地通过使由式（II）表示的卤代不饱和羰基化合物与醇化物反应而方便地并且以较少的步骤制备由式（III）表示的环丙烷单缩醛衍生物的方法。 其中每个符号如说明书中所定义。
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公开(公告)号：US06218548B1
公开(公告)日：2001-04-17
申请号：US09447831
申请日：1999-11-23
Applicant: Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
Inventor： Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
IPC: C07D20954
CPC classification number: C07C271/22 , C07C255/31 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/54
Abstract: A compound represented by formula (III): wherein n is an integer of 2 to 5; and R11 represents a substituent group represented by formula: wherein Ra, Rb and Rc each represents a phenyl, phenylmethyl or naphthyl group (which may be substituted with at least one substituent group selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a halogen atom and a nitro group), a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms, with the proviso that Ra, Rb and Rc are different from one another, and a salt thereof.
Abstract translation: 由式（III）表示的化合物：其中n是2至5的整数; R 11表示由下式表示的取代基：其中R a，R b和R c各自表示苯基，苯甲基或萘基（其可以被至少一个选自具有1至4个碳原子的烷基的取代基取代， 具有1至4个碳原子的烷氧基，卤素原子和硝基），氢原子或具有1至4个碳原子的烷基，条件是Ra，Rb和Rc彼此不同，以及 其盐。
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公开(公告)号：US5856518A
公开(公告)日：1999-01-05
申请号：US952930
申请日：1997-11-26
Applicant: Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
Inventor： Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
IPC: C07C255/31 , C07C271/22 , C07D209/54 , C07D207/12 , C07C255/03
CPC classification number: C07C271/22 , C07C255/31 , C07D209/54 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
Abstract: This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of folmula (I), and also to provide a novel synthetic process for the inexpensive, short-step and industrially advantageous production thereof. ##STR1##
Abstract translation: PCT No.PCT / JP96 / 01373 Sec。 371日期：1997年11月26日 102（e）1997年11月26日PCT PCT 1996年5月23日PCT公布。 WO96 / 37470 PCT公开号 日本特开1996年11月28日本发明是提供下述式（I）所示的化合物和下述通式（II）所示的化合物和下述式（II）表示的化合物，其可用作通过下述（I）的化合物得到的抗菌剂， 提供了一种新颖的合成方法，用于其廉价，短期和工业上有利的生产。 （I）
（II）
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8.发明授权Process for producing cyclopropane monoacetal derivative and intermediate therefor 失效制备环丙烷单缩醛衍生物及其中间体的方法
公开(公告)号：US07358400B2
公开(公告)日：2008-04-15
申请号：US10593129
申请日：2005-03-25
Applicant: Kenichi Koyakumaru , Shingo Ueyama , Katsuji Ujita , Tatsuhiko Hayashibara , Naoshi Nakagawa , Toshifumi Akiba , Tatsuru Saito
Inventor： Kenichi Koyakumaru , Shingo Ueyama , Katsuji Ujita , Tatsuhiko Hayashibara , Naoshi Nakagawa , Toshifumi Akiba , Tatsuru Saito
CPC classification number: C07C45/59 , C07C45/65 , C07C45/70 , C07C47/277 , C07C47/37 , C07C2601/02
Abstract: A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.
Abstract translation: 工业上有利地通过使由式（II）表示的卤代不饱和羰基化合物与醇化物反应而方便地并且以较少的步骤制备由式（III）表示的环丙烷单缩醛衍生物的方法。 其中每个符号如说明书中所定义。
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公开(公告)号：US6013806A
公开(公告)日：2000-01-11
申请号：US112379
申请日：1998-07-09
Applicant: Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
Inventor： Toshifumi Akiba , Tutomu Ebata , Tatsuru Saito , Sadahiro Shimizu , Keiichi Hirai , Naoki Ohta , Toshiaki Tojo
IPC: C07C255/31 , C07C271/22 , C07D209/54
CPC classification number: C07C271/22 , C07C255/31 , C07D209/54 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
Abstract: This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of formula (I), and also to provide a novel synthetic process for the inexpensive, short-step and industrially advantageous production thereof. ##STR1##
Abstract translation: 本发明提供由下式（I）表示的化合物和由下式（II）表示的化合物，其可用作通过式（I）化合物获得的抗菌剂，并且还提供新的合成 其制造成本低廉且工业上有利的生产方法。
