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1.发明授权公开(公告)号：US09435809B2
公开(公告)日：2016-09-06
申请号：US14232801
申请日：2012-07-13
Applicant: Stephen D. Nimer , Lan Wang
Inventor： Stephen D. Nimer , Lan Wang
IPC: C12Q1/00 , C12N15/01 , G01N33/574 , G01N33/50 , C07K16/44 , C12N15/113 , C12Q1/68
CPC classification number: G01N33/57426 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2317/40 , C12N15/1135 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/47 , G01N2440/10 , G01N2500/00 , G01N2500/04
Abstract: The present invention relates to methods and compositions for treating and reducing the risk of Acute Myelogenous Leukemia (AML). In particular, the invention provides methods for identifying novel treatments for AML based on reproducible and detectable changes in AML1-ETO acetylation. The present invention further provides methods of using these treatments.
Abstract translation: 本发明涉及治疗和降低急性骨髓性白血病（AML）风险的方法和组合物。 特别地，本发明提供了基于AML1-ETO乙酰化可重复和可检测的变化来鉴定AML的新治疗的方法。 本发明还提供了使用这些处理的方法。
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公开(公告)号：US20140348840A1
公开(公告)日：2014-11-27
申请号：US14232801
申请日：2012-07-13
Applicant: Stephen D. Nimer , Lan Wang
Inventor： Stephen D. Nimer , Lan Wang
IPC: G01N33/574 , C12Q1/68 , G01N33/50
CPC classification number: G01N33/57426 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2317/40 , C12N15/1135 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2333/47 , G01N2440/10 , G01N2500/00 , G01N2500/04
Abstract: The present invention relates to methods and compositions for treating and reducing the risk of Acute Myelogenous Leukemia (AML). In particular, the invention provides methods for identifying novel treatments for AML based on reproducible and detectable changes in AML1-ETO acetylation. The present invention further provides methods of using these treatments.
Abstract translation: 本发明涉及用于治疗和降低急性骨髓性白血病（AML）风险的方法和组合物。 特别地，本发明提供了基于AML1-ETO乙酰化可重复和可检测的变化来鉴定AML的新治疗的方法。 本发明还提供了使用这些处理的方法。
