Methods for preventing and/or treating lysosomal storage disorders
    4.
    发明授权
    Methods for preventing and/or treating lysosomal storage disorders 有权
    用于预防和/或治疗溶酶体储存障碍的方法

    公开(公告)号:US08940766B2

    公开(公告)日:2015-01-27

    申请号:US12757160

    申请日:2010-04-09

    CPC classification number: C12Q1/34 A61K31/445 C07D211/36 G01N2333/924

    Abstract: The present invention provides methods for preventing and/or treating lysosomal storage disorders using 5-(fluoromethyl)piperidine-3,4-diol, 5-(chloromethyl)piperidine-3,4-diol, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, or any combination of two or more thereof. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.

    Abstract translation: 本发明提供使用5-(氟甲基)哌啶-3,4-二醇,5-(氯甲基)哌啶-3,4-二醇或其药学上可接受的盐,溶剂合物或/或溶剂合物来预防和/或治疗溶酶体贮积病的方法 前药,或其两种或多种的任何组合。 特别地,本发明提供了预防和/或治疗戈谢氏病的方法。

    Golf clubs and golf club heads having targeted weighting characteristics
    6.
    发明授权
    Golf clubs and golf club heads having targeted weighting characteristics 有权
    具有目标加权特性的高尔夫球杆和高尔夫球杆头

    公开(公告)号:US08506421B2

    公开(公告)日:2013-08-13

    申请号:US12029217

    申请日:2008-02-11

    Abstract: Wood-type golf club heads include: (a) a ball striking face member; and (b) a club head body attached to or integrally formed with the face member. One body component of the club head (e.g., a weight or cover member) may be formed from a transparent, partially transparent, or translucent material. In some club head structures, an external weight member may extend around a part of a club head body member and beyond or outside of at least a portion of the body member's exterior perimeter (e.g., rearwardly, laterally toward a toe side, and/or laterally toward a heel side of the club head body, beyond the exterior perimeter portion, when viewed from overhead). Golf club structures that include golf club heads, e.g., of the types described above, and methods of constructing and/or using such clubs and club heads, also are described.

    Abstract translation: 木型高尔夫球杆头包括:(a)击球面部件; 和(b)附接到面部构件或与面部构件一体形成的球杆头主体。 球杆头的一个主体部件(例如,重量或盖部件)可以由透明的,部分透明的或半透明的材料形成。 在一些球杆头结构中,外部配重构件可以围绕球杆头主体构件的一部分延伸并且超过或超出身体构件的外周的至少一部分(例如,向后,侧向朝向脚趾侧,和/或 横向地朝向球杆头本体的后跟侧,超过外周边部分,当从塔顶观察时)。 还描述了包括例如上述类型的高尔夫球杆头的高尔夫俱乐部结构以及构造和/或使用这种球杆和杆头的方法。

    Golf Club Head Or Other Ball Striking Device Utilizing Energy Transfer
    7.
    发明申请
    Golf Club Head Or Other Ball Striking Device Utilizing Energy Transfer 有权
    高尔夫球杆头或其他使用能量转移的球打击装置

    公开(公告)号:US20130137533A1

    公开(公告)日:2013-05-30

    申请号:US13308079

    申请日:2011-11-30

    Abstract: A head for a ball striking device, such as a golf club head, includes a face member having a face with a striking surface configured for striking a ball and a rear surface opposite the striking surface, a weight member connected to the face member behind the rear surface of the face member, and a resilient member positioned between the weight member and the face member. The resilient member is connected to the rear surface of the face member to connect the weight member to the face member. The resilient member is compressible to permit energy and/or momentum to be transferred between the weight member and the face member through the resilient member during impact, including an off-center impact on the striking surface. Momentum transferred from the weight member to the face member during an off-center impact may reduce energy loss and twisting of the face on impact.

    Abstract translation: 用于诸如高尔夫球杆头的击球装置的头部包括面部构件,所述面部构件具有构造成用于击打球的撞击表面和与击打表面相对的后表面的面,配重构件连接到面部构件 面部构件的后表面,以及定位在配重构件和面构件之间的弹性构件。 弹性构件连接到面构件的后表面,以将配重构件连接到面构件。 弹性构件是可压缩的,以允许能量和/或动量在冲击期间通过弹性构件在配重构件和面构件之间传递,包括对冲击表面的偏心冲击。 在偏心冲击期间从重量部件转移到面部部件的动量可能减少冲击时的能量损失和扭曲。

    Golf club with adjustable weight
    10.
    发明授权
    Golf club with adjustable weight 有权
    高尔夫俱乐部,重量可调

    公开(公告)号:US08425348B2

    公开(公告)日:2013-04-23

    申请号:US12894390

    申请日:2010-09-30

    Abstract: A golf club with a golf club head having one or more adjustable weights is presented. The club head may include a club head body having a recessed formed therein. In some arrangements, the recess may be formed in a sole portion of the club head body. The golf club head further includes an adjustable weight that may be rotated from a first position to a second position to adjust the weight characteristics, and thus the performance characteristics of the golf club. In some arrangements, the adjustable weight and/or any hardware, fasteners, etc. associated with the adjustable weight may be constantly connected to the golf club head such that adjustment of the weight does not include removal of the weight and/or any hardware, fasteners, etc.

    Abstract translation: 呈现具有一个或多个可调重量的高尔夫球杆头的高尔夫球杆。 球杆头可以包括其中形成有凹陷的球杆头主体。 在一些布置中,凹部可以形成在球杆头本体的底部中。 高尔夫球杆头还包括可调整的重量,其可以从第一位置旋转到第二位置,以调节重量特征,并因此调节高尔夫球杆的性能特征。 在一些布置中,与可调重量相关联的可调节重量和/或任何硬件,紧固件等可以恒定地连接到高尔夫球杆头,使得重量的调节不包括重量的移除和/或任何硬件, 紧固件等

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