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公开(公告)号：US20060015002A1
公开(公告)日：2006-01-19
申请号：US11142078
申请日：2005-05-31
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
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公开(公告)号：US20050182487A1
公开(公告)日：2005-08-18
申请号：US11106421
申请日：2005-04-14
申请人： Patrick McCarthy , Richard Rhee , Stefan Schreck
发明人： Patrick McCarthy , Richard Rhee , Stefan Schreck
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2230/0091 , A61F2250/0029 , A61F2250/0036 , A61F2250/0037 , Y10S623/90
摘要： An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends. A deliver template having a mounting ring with about the same shape as the ring facilitates implant, and may be releasably attached to a delivery handle. The deliver template may include a plurality of cutting guides for releasably attaching the annuloplasty ring thereto while presenting maximum outer surface area of the ring. The template may have an outwardly-facing groove to receive and retain the ring.
摘要翻译： 具有三维不连续形状的瓣环成形术环通常围绕具有轴向偏移的两个自由端的轴线布置。 该环特别适用于修复三尖瓣，并且更接近于环形。 环绕径向延伸的轴弯曲比围绕中心轴更弯曲。 环可以具有由柔韧的套筒和/或织物管覆盖的内部结构支撑。 结构支撑件可以具有变化的横截面，例如两个自由端之间的中间部分中的C形横截面和在自由端处的矩形横截面。 具有与环具有大致相同形状的安装环的输送模板便于植入，并且可以可释放地附接到递送手柄。 递送模板可以包括多个切割引导件，用于可释放地将瓣环成形术环附接到其上，同时具有环的最大外表面面积。 模板可以具有向外的凹槽以接收和保持环。
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公开(公告)号：US20050171601A1
公开(公告)日：2005-08-04
申请号：US11095982
申请日：2005-03-30
申请人： Delos Cosgrove , Stefan Schreck , Richard Rhee
发明人： Delos Cosgrove , Stefan Schreck , Richard Rhee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466
摘要： An annuloplasty repair segment and template for heart valve annulus repair. The elongate flexible template may form a distal part of a holder that also has a proximal handle. Alternatively, the template may be releasably attached to a mandrel that slides within a delivery sheath, the template being released from the end of the sheath to enable manipulation by a surgeon. A tether connecting the template and mandrel may also be provided. The template may be elastic, temperature responsive, or multiple linked segments. The template may be aligned with the handle and form a two- or three-dimensional curve out of alignment with the handle such that the annuloplasty repair segment attached thereto conforms to the curve. The template may be actively or passively converted between its straight and curved positions. The combined holder and ring is especially suited for minimally-invasive surgeries in which the combination is delivered to an implantation site through a small access incision with or without a cannula, or through a catheter passed though the patient's vasculature.
摘要翻译： 用于心脏瓣膜环修复的瓣膜成形术修复部分和模板。 细长的柔性模板可以形成也具有近端手柄的保持器的远端部分。 或者，模板可以可释放地附接到在输送护套内滑动的心轴，模板从护套的端部释放以允许外科医生进行操纵。 还可以提供连接模板和心轴的系绳。 模板可以是弹性的，温度敏感的或多个链接的段。 模板可以与手柄对准并且形成与手柄对准的二维或三维曲线，使得附接到其上的瓣膜成形术修复段符合曲线。 模板可以在其直线位置和弯曲位置之间被主动地或被动地转换。 组合的保持器和环特别适用于微创手术，其中组合通过具有或不具有插管的小切口切口或通过穿过患者脉管系统的导管递送至植入部位。
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公开(公告)号：US09011480B2
公开(公告)日：2015-04-21
申请号：US13355295
申请日：2012-01-20
申请人： Vince Divino , Richard Rhee , Rich Kusleika
发明人： Vince Divino , Richard Rhee , Rich Kusleika
CPC分类号： A61B17/12145 , A61B17/12031 , A61B17/12113 , A61B17/1215 , A61B17/12154 , A61B2017/00526 , A61B2017/00778 , A61B2017/00867 , A61B2017/00898 , A61B2017/12054 , A61B2017/12063 , A61B2090/3966 , A61F2/01 , A61F2230/0091 , A61M25/0021 , A61M2025/0042 , B21F3/02 , B21F45/16
摘要： Systems and devices for endovascular treatment of intracranial aneurysms are described. Various configurations of coiled implants may be used as stenting devices or aneurysm coils. The implants include one or more filaments wound about a longitudinal axis to form a generally tubular shape. Lateral flexibility of the implants may be manipulated by, for example, adjusting a pitch between adjacent filaments, using different materials for the filaments, employing different filament cross-sectional shapes, grouping filaments into pluralities of varying flexibilities, and nesting inner coils within outer coils.
摘要翻译： 描述了用于颅内动脉瘤血管内治疗的系统和装置。 螺旋植入物的各种构造可以用作支架装置或动脉瘤线圈。 植入物包括围绕纵向轴线缠绕的一个或多个细丝以形成大致管状的形状。 植入物的侧向柔性可以通过例如调节相邻细丝之间的间距来进行操作，使用不同的长丝材料，使用不同的细丝横截面形状，将丝分成多个变化的柔性，以及将内部线圈嵌套在外部线圈内 。
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公开(公告)号：US20080293995A1
公开(公告)日：2008-11-27
申请号：US12177052
申请日：2008-07-21
IPC分类号： A61N2/10
CPC分类号： A61F2/2481 , A61B17/3468 , A61B2017/00876 , A61F2/2478 , A61F2/2487 , A61F2002/249 , A61F2210/009 , A61N2/00
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用磁力重塑心脏解剖结构治疗的心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。 磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US07402134B2
公开(公告)日：2008-07-22
申请号：US11142127
申请日：2005-05-31
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61B17/3468 , A61B2017/00876 , A61F2/2478 , A61F2/2487 , A61F2002/249 , A61F2210/009 , A61N2/00
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用磁力重塑心脏解剖结构治疗的心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。 磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US20080039681A1
公开(公告)日：2008-02-14
申请号：US11876586
申请日：2007-10-22
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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8.发明申请Vascular stent which is specially designed for the multiple drug loading and better drug elution 审中-公开血管支架特别设计用于多种药物装载和更好的药物洗脱公开(公告)号：US20070123974A1
公开(公告)日：2007-05-31
申请号：US11585028
申请日：2006-10-23
申请人： Jeong Park , Richard Rhee
发明人： Jeong Park , Richard Rhee
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2250/0035 , A61F2250/0068 , A61L31/16 , A61L2300/608
摘要： Provided is a vascular stent used in percutaneous coronary intervention (PCI) which is specially designed for multiple drug loading and improved drug elution, including: a plurality of ring structures extending in the longitudinal direction of the vascular stent, including a plurality of struts disposed in a zigzag formation and connected to each other to form a cylindrical loop; and a plurality of link structures disposed between the ring structures and connecting the ring structures in the longitudinal direction of the vascular stent, wherein each of the struts in a ring structure is connected to adjacent struts in the same ring structure through one of a plurality of linking ends, a slot loaded with drugs is formed in the strut in the longitudinal direction of the strut, and a multi-layer structure comprising a plurality of layers of drugs is loaded in the slot. The vascular stent effectively inhibits restenosis by loading a large amount of a drug or various types of drugs in multiple layers in slots of struts in the vascular stent and controlling elution of the drugs, and can be easily installed in a serpentine coronary artery with excellent flexibility. In addition, the link structure of the vascular stent is disposed in a symmetric formation, and thus, side branch accessibility is excellent and an additional coronary intervention can be performed easily in a branched artery.
摘要翻译： 提供了一种用于经皮冠状动脉介入术（PCI）的血管支架，其特别设计用于多种药物装载和改进的药物洗脱，包括：在血管支架的纵向方向上延伸的多个环结构，包括多个支架， 一个Z字形并相互连接形成一个圆柱形环; 以及多个连接结构，其设置在所述环形结构之间并且在所述血管支架的纵向方向上连接所述环形结构，其中环形结构中的每个支柱通过多个 在支柱的长度方向上在支柱上形成装载有药物的狭缝，并且包含多层药物的多层结构被装载在狭槽中。 血管支架通过在血管支架的支柱狭槽中多层加载大量药物或多种药物，控制药物的洗脱，有效地抑制再狭窄，并且可以容易地安装在具有优异柔性的蛇形冠状动脉 。 此外，血管支架的连接结构以对称形式设置，因此侧支辅助性优异，并且在分支动脉中可以容易地进行额外的冠状动脉介入治疗。
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公开(公告)号：US20070055368A1
公开(公告)日：2007-03-08
申请号：US11514292
申请日：2006-08-31
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices comprise a shape memory material, and further include a body member and an insert member. The body member has a circumference and a slot that extends at least partially along the circumference of the body. The insert member extends at least partially along the circumference of the body. The device has a first shape in a first configuration and a second shape in a second configuration, and is configured to transform from a first configuration to a second configuration in response to a first activation energy applied thereto.
摘要翻译： 提供了用于支撑身体结构的方法和装置。 这些装置可以以微创或非侵入性的方式在患者身体内进行调节，例如通过经皮或外部给患者身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括形状记忆材料，并且还包括主体构件和插入构件。 主体构件具有至少部分地沿主体的圆周延伸的圆周和狭槽。 插入构件至少部分地沿身体的圆周延伸。 该装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的第一激活能量而从第一配置变换到第二配置。
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公开(公告)号：US20060015178A1
公开(公告)日：2006-01-19
申请号：US11181686
申请日：2005-07-14
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson , Richard Rhee , Steven Anderson
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson , Richard Rhee , Steven Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.
摘要翻译： 提供组织成形方法和装置用于加强和/或改造心脏瓣膜。 在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。 这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。 在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。 形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。 形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。 在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。
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