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    Anthrose-based compositions and related methods
    3.
    发明申请
    Anthrose-based compositions and related methods 审中-公开
    基于Anthrose的组合物和相关方法

    公开(公告)号：US20150265691A1

    公开(公告)日：2015-09-24

    申请号：US11901234

    申请日：2007-09-14

    Applicant: Denong Wang ,  Pavol Kovac ,  Lawrence Steinman ,  Gregory Carroll ,  Nicholas Turro ,  Jeffrey Koberstein ,  Rina Saksena ,  Roberto Adamo

    Inventor： Denong Wang ,  Pavol Kovac ,  Lawrence Steinman ,  Gregory Carroll ,  Nicholas Turro ,  Jeffrey Koberstein ,  Rina Saksena ,  Roberto Adamo

    IPC: A61K39/07 ,  G01N33/68 ,  G01N33/569 ,  A61K47/48 ,  C07K16/12 ,  C07K16/42

    CPC classification number: A61K39/07 ,  A61K47/61 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/55566 ,  A61K2039/6068 ,  A61K2039/6081 ,  C07K16/1278 ,  C12Q1/04 ,  G01N33/56911 ,  G01N2333/32 ,  G01N2469/10

    Abstract: This invention provides a vaccine comprising (i) an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject and (ii) a pharmaceutically acceptable carrier. This invention provides a vaccine comprising (i) a conjugate of an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in a subject, wherein the anthrose-containing saccharide is conjugated to a biomolecule via a linker, and (ii) a pharmaceutically acceptable carrier. This invention provides a method for vaccinating a subject against Bacillus anthracis infection comprising administering to the subject a vaccine comprising (i) an anthrose-containing saccharide in an amount effective to enhance immunity against Bacillus anthracis in the subject and (ii) a pharmaceutically acceptable carrier, in an amount effective to stimulate production of antibodies to Bacillus anthracis spores in the subject, thereby vaccinating the subject against Bacillus anthracis.

    Abstract translation: 本发明提供了一种疫苗，其包含（i）含有量的含有糖的糖类，其量有效地增强受试者中对炭疽杆菌的免疫力，和（ii）药学上可接受的载体。 本发明提供了一种疫苗，其包含（i）含有含量的含糖的糖类的缀合物，其有效量以增强受试者中对炭疽芽孢杆菌的免疫力，其中所述含有所述含烟糖的糖通过接头与生物分子缀合，和（ii） 药学上可接受的载体。 本发明提供了一种针对炭疽芽孢杆菌感染接种受试者的方法，其包括向所述受试者施用疫苗，所述疫苗包含（i）含有有效量以提高受试者中对于炭疽杆菌的免疫力的含量的含有糖的糖类，以及（ii）药学上可接受的载体 ，其量有效地刺激在受试者中产生炭疽芽孢杆菌孢子的抗体，从而使受试者接种针对炭疽芽孢杆菌的疫苗。

    Linking compounds useful for coupling carbohydrates to amine-containing carriers
    4.
    发明授权
    Linking compounds useful for coupling carbohydrates to amine-containing carriers 有权
    用于将碳水化合物偶联至含胺载体的连接化合物

    公开(公告)号：US5952454A

    公开(公告)日：1999-09-14

    申请号：US183053

    申请日：1998-10-30

    Applicant: Pavol Kovac ,  Jian Zhang

    Inventor： Pavol Kovac ,  Jian Zhang

    IPC: A61K39/385 ,  C07H15/12 ,  C08G69/26

    CPC classification number: C07H15/12 ,  A61K39/385 ,  A61K2039/6081 ,  A61K2039/627

    Abstract: The present invention provides a method to couple a glycosyl donor to an amine-containing carrier or substrate material using as a spacer a compound of the general formula I: ##STR1## in which n and m are each independently an integer of from 1 to 12, R.sub.1 and R.sub.2 are each independently H, lower alkyl, a hydroxyl group, or a substituent which does not interfere with the linking reactions, R.sub.4 and R.sub.5 are each independently H, lower alkyl, a hydroxyl group, or a substituent which does not interfere with the linking reactions, R.sub.3 and R'.sub.3 are each independently an optionally substituted lower alkyl or R.sub.3 and R'.sub.3 can be joined to form an optionally substituted cyclic moiety having from 2 to 5 carbon atoms.

    Abstract translation: 本发明提供了使用通式I化合物作为间隔物将糖供体偶联到含胺载体或底物材料的方法：其中n和m各自独立地为1至12的整数，R 1和 R2各自独立地为H，低级烷基，羟基或不干扰连接反应的取代基，R4和R5各自独立地为H，低级烷基，羟基或不干扰连接的取代基 反应，R 3和R'3各自独立地是任选取代的低级烷基或R 3，且R'3可以连接形成任选取代的具有2至5个碳原子的环状部分。

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