公开(公告)号：US08923470B2

公开(公告)日：2014-12-30

申请号：US12994449

申请日：2009-05-27

Applicant: Bruno Convert ,  Thierry Favre ,  Jean Hericourt ,  Arnauld Deniau ,  Pascal Pierre ,  Badia Amekraz

Inventor： Bruno Convert ,  Thierry Favre ,  Jean Hericourt ,  Arnauld Deniau ,  Pascal Pierre ,  Badia Amekraz

IPC: G21C3/00 ,  F16J13/12 ,  G21F5/12 ,  G21F5/00 ,  B65D41/16 ,  B65D41/10 ,  B65D41/02

CPC classification number: G21F5/12 ,  B65D41/026 ,  B65D41/10 ,  B65D41/16 ,  F16J13/12 ,  G21Y2002/206 ,  G21Y2002/303 ,  G21Y2002/60 ,  G21Y2004/30

Abstract: The container is comprised of a side wall of which the end edges are each provided with a blocking member, of which at least one is inserted in order to close an opening. The peripheral outline of the inserted blocking member and the interior outline of the associated end edge of the side wall have generally complementary shapes on at least one portion of their respective heights, in such a way that said inserted blocking member comes to be housed on at least one portion of its height in the space defined by said end edge of the side wall and comes to bear against said end edge by adjusting lugs in recesses of complementary shape. The inclined joining surfaces form an angle from 20° to 40° with the axis of the container.

Abstract translation: 容器由侧壁构成，端缘各自设置有阻挡构件，其中插入至少一个以封闭开口。 插入的阻挡构件的外围轮廓和侧壁的相关联的端部边缘的内部轮廓在它们各自的高度的至少一部分上具有大致互补的形状，使得所述插入的阻挡构件被容纳在 在由所述侧壁的所述端缘限定的空间中，其高度的至少一部分通过调节互补形状的凹槽中的凸耳而抵靠所述端部边缘。 倾斜的接合表面与容器的轴线成20°至40°的角度。

公开(公告)号：US08173650B2

公开(公告)日：2012-05-08

申请号：US12787613

申请日：2010-05-26

Applicant: Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

Inventor： Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

IPC: A61K31/535 ,  C07D413/14

CPC classification number: C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 式（I）和（Ib）化合物，其中（i）X1为N，X 2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，或（iv）X1为CR7， X 2为O，包括立体异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20110077449A1

公开(公告)日：2011-03-31

申请号：US12994449

申请日：2009-05-27

Applicant: Bruno Convert ,  Thierry Favre ,  Jean Hericourt ,  Arnauld Deniau ,  Pascal Pierre ,  Badia Amekraz

Inventor： Bruno Convert ,  Thierry Favre ,  Jean Hericourt ,  Arnauld Deniau ,  Pascal Pierre ,  Badia Amekraz

IPC: G21F9/00 ,  B65D45/00

CPC classification number: G21F5/12 ,  B65D41/026 ,  B65D41/10 ,  B65D41/16 ,  F16J13/12 ,  G21Y2002/206 ,  G21Y2002/303 ,  G21Y2002/60 ,  G21Y2004/30

Abstract: The container is comprised of a side wall of which the end edges are each provided with a blocking member, of which at least one is inserted in order to close an opening.The peripheral outline of the inserted blocking member and the interior outline of the associated end edge of the side wall have generally complementary shapes on at least one portion of their respective heights, in such a way that said inserted blocking member comes to be housed on at least one portion of its height in the space defined by said end edge of the side wall and comes to bear against said end edge by adjusting lugs in recesses of complementary shape. The inclined joining surfaces form an angle from 20° to 40° with the axis of the container.

Abstract translation: 容器由侧壁构成，端缘各自设置有阻挡构件，其中插入至少一个以封闭开口。 插入的阻挡构件的外围轮廓和侧壁的相关联的端部边缘的内部轮廓在它们各自的高度的至少一部分上具有大致互补的形状，使得所述插入的阻挡构件被容纳在 在由所述侧壁的所述端缘限定的空间中，其高度的至少一部分通过调节互补形状的凹槽中的凸耳而抵靠所述端部边缘。 倾斜的接合表面与容器的轴线成20°至40°的角度。

公开(公告)号：USD401964S

公开(公告)日：1998-12-01

申请号：US55938

申请日：1996-06-17

Applicant: Patrick Lardant ,  Pascal Pierre-Francois

Designer： Patrick Lardant ,  Pascal Pierre-Francois

公开(公告)号：US08841462B2

公开(公告)日：2014-09-23

申请号：US12999003

申请日：2009-07-01

Applicant: Robert A. Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

Inventor： Robert A. Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

IPC: C07D275/04 ,  C07D231/56 ,  C07D513/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/428 ,  A61K31/416

CPC classification number: C07D231/56 ,  C07D275/04 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract translation: 本发明涉及式I和II的双环杂环，其具有抗癌和/或抗炎活性，更具体地涉及MEK激酶抑制活性。 本发明提供了可用于抑制异常细胞生长，治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US20130060009A1

公开(公告)日：2013-03-07

申请号：US13576980

申请日：2011-02-02

Applicant: Jean-Pascal Pierre Bilgischer ,  Philip Jonathan Bassett ,  Mark Robert Pearce-Higgins ,  Andrew John Kenny

Inventor： Jean-Pascal Pierre Bilgischer ,  Philip Jonathan Bassett ,  Mark Robert Pearce-Higgins ,  Andrew John Kenny

IPC: C12P21/00 ,  C07K16/00

CPC classification number: C07K16/00 ,  C07K2317/14 ,  C07K2317/55

Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

Abstract translation: 本公开涉及一种制备重组抗体分子的方法，包括培养用编码重组抗体分子的表达载体转化的宿主细胞样品; 向样品中加入提取缓冲液; 并对样品进行热处理步骤; 其中在加入提取缓冲液之后检测样品的pH，并任选地调节，以确保在热处理步骤之前样品的pH为6至9。

公开(公告)号：US20100280063A1

公开(公告)日：2010-11-04

申请号：US12808346

申请日：2008-12-18

Applicant: Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

Inventor： Stephen Price ,  Robert Heald ,  Pascal Pierre Alexandre Savy

IPC: A61K31/437 ,  C07D471/04 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract translation: 本发明涉及式I的咪唑并吡啶与抗癌和/或抗炎活性，更具体地涉及抑制MEK激酶活性的咪唑并吡啶类。 本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US6011571A

公开(公告)日：2000-01-04

申请号：US358

申请日：1998-01-28

Applicant: Patrick Lardant ,  Pascal Pierre-Francois

Inventor： Patrick Lardant ,  Pascal Pierre-Francois

IPC: B41J11/20 ,  B41J15/04 ,  B41J29/02 ,  B41J25/304

CPC classification number: B41J29/02 ,  B41J11/20 ,  B41J15/04

Abstract: A thermal printer mechanism comprising an elongate support (1), a drive roller (4), a strip of print elements (3) mounted on said support, spring-forming means for urging said strip against the drive roller, at least one cam (5) mounted to pivot about an axis (A.sub.2) of the support (1) to move the strip (3) away from the drive roller (4), said mechanism being characterized in that it can be transformed from a stationary-roller version to a retractable-roller version, and in that the axle about which the drive roller (4) rotates is suitable for being selectively mounted either on the support (1), or on a paper-protecting cover (CP) hinged to said support (1), the cam of the stationary version being suitable for being replaced with at least one other cam suitable for being entrained by the paper-protecting cover being tipped up and vice versa.

Abstract translation: PCT No.PCT / FR96 / 01193 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年7月29日PCT公布。 出版物WO97 / 04966 日期1997年2月13日热敏打印机机构包括细长支撑件（1），驱动辊（4），安装在所述支撑上的打印元件条（3），用于将所述条带推靠在驱动辊上的弹簧形成装置， 安装成围绕所述支撑件（1）的轴线（A2）枢转以将所述带材（3）移动远离所述驱动辊（4）的至少一个凸轮（5），所述机构的特征在于其可以从 固定辊版本为可伸缩辊版本，并且驱动辊（4）围绕其旋转的轴适合于选择性地安装在支撑件（1）上或铰接在纸保护盖（CP）上 对于所述支撑件（1），所述固定型式的凸轮适于被至少一个其他凸轮所替代，所述至少一个其它凸轮适于被所述纸保护盖夹带，反之亦然。

公开(公告)号：US5149713A

公开(公告)日：1992-09-22

申请号：US704302

申请日：1991-05-22

Applicant: Pascal-Pierre Bousquet

Inventor： Pascal-Pierre Bousquet

IPC: A61K31/195 ,  A61P9/08 ,  A61P9/10 ,  C07C229/34

CPC classification number: A61K31/195

Abstract: The invention relates to the use of baclofen for the treatment of angina pectoris.

Abstract translation: 本发明涉及巴氯芬用于治疗心绞痛的用途。

公开(公告)号：US09103212B2

公开(公告)日：2015-08-11

申请号：US13502471

申请日：2010-10-13

Applicant: Pascal Pierre Le Brusq ,  Jean-Philippe Ousty ,  Lionel Scuiller

Inventor： Pascal Pierre Le Brusq ,  Jean-Philippe Ousty ,  Lionel Scuiller

IPC: F01D5/06 ,  F01D5/02 ,  F01D11/00 ,  F04D29/08 ,  F04D29/16 ,  F04D29/58 ,  F16D1/033 ,  F16D11/00

CPC classification number: F01D5/066 ,  F01D5/025 ,  F01D11/001 ,  F04D29/083 ,  F04D29/161 ,  F04D29/584 ,  F16D1/033 ,  F16D2011/008 ,  F16D2300/021

Abstract: A method to prevent blockage of air passages in curvic couplings between drive parts and to prevent potential damage to the drive parts during weakening of protective elements. To this end, axial abutments are formed by ring gears of the curvic couplings. A coupling includes two rings, each ring being on the end of one drive part and engaged with the other so as to transmit to the drive part a rotation around a central axis while allowing air to pass between male and female portions of the teeth of the rings behind a bearing area. The rings are extended in an at least partially radial manner relative to each other to form an outer ring extension and an inner ring extension respectively facing elements surrounding the drive part that are mounted onto the other ring. The rotor lines can be used in turbine engines.

Abstract translation: 防止驱动部件之间的弯曲联轴器中的空气通道堵塞并防止在保护元件削弱期间对驱动部件的潜在损坏的方法。 为此，轴向邻接由曲线联轴器的环形齿轮形成。 联接器包括两个环，每个环在一个驱动部分的端部上并且与另一个接合，以便传递到驱动部分围绕中心轴线的旋转，同时允许空气通过在 环在轴承区后面。 环以相对于彼此至少部分径向的方式延伸以形成外环延伸部和分别面向围绕驱动部分的元件的内环延伸，所述内环延伸部安装在另一个环上。 转子线可用于涡轮发动机。