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公开(公告)号：US20230190822A1
公开(公告)日：2023-06-22
申请号：US17923431
申请日：2021-05-05
Applicant: PLURI BIOTECH LTD.
Inventor： Rachel Ofir , Zami Aberman , Niva Shraga Heled
IPC: A61K35/50 , C12N5/0775
CPC classification number: A61K35/50 , C12N5/0668 , C12N2500/90
Abstract: Disclosed herein are compositions comprising subcellular fractions from expanded placental adherent stromal cells, and methods utilizing same.
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公开(公告)号：US20240392225A1
公开(公告)日：2024-11-28
申请号：US18593868
申请日：2024-03-02
Applicant: PLURI BIOTECH LTD.
Inventor： Lior RAVIV , Shirley BACHAR , Dorina ROBERMAN
Abstract: This invention discloses a three-dimensional (3D) bioreactor for large scale expansion of immune cells and methods of use. The 3D bioreactor comprising at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extra cellular matrix protein (ECM); at least one container comprising a fluid media, the fluid media is configured to flow through said packed bed chamber with at least one porous coated scaffold; and at least one population of immune cells suspended in the fluid media, wherein, the at least one porous scaffold coated with said ECM is creates a stationary niche having low shear forces that imitate the natural growth environment of the immune cells and allows expansion of the immune cells population that flow through the coated porous scaffold in large scale.
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公开(公告)号：US11939562B2
公开(公告)日：2024-03-26
申请号：US18200942
申请日：2023-05-23
Applicant: PLURI BIOTECH LTD.
Inventor： Lior Raviv , Shirley Bachar , Dorina Roberman
CPC classification number: C12M25/14 , C12M23/02 , C12M23/20 , C12M25/18 , C12N5/0634 , C12N2513/00
Abstract: This invention discloses a three-dimensional (3D) bioreactor for large scale expansion of immune cells and methods of use. The 3D bioreactor comprising at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extra cellular matrix protein (ECM); at least one container comprising a fluid media, the fluid media is configured to flow through said packed bed chamber with at least one porous coated scaffold; and at least one population of immune cells suspended in the fluid media, wherein, the at least one porous scaffold coated with said ECM is creates a stationary niche having low shear forces that imitate the natural growth environment of the immune cells and allows expansion of the immune cells population that flow through the coated porous scaffold in large scale.
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公开(公告)号：US20230374433A1
公开(公告)日：2023-11-23
申请号：US18200942
申请日：2023-05-23
Applicant: PLURI BIOTECH LTD.
Inventor： Lior RAVIV , Shirley BACHAR , Dorina ROBERMAN
CPC classification number: C12M25/14 , C12M23/02 , C12M25/18 , C12M23/20 , C12N5/0634 , C12N2513/00
Abstract: This invention discloses a three-dimensional (3D) bioreactor for large scale expansion of immune cells and methods of use. The 3D bioreactor comprising at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extra cellular matrix protein (ECM); at least one container comprising a fluid media, the fluid media is configured to flow through said packed bed chamber with at least one porous coated scaffold; and at least one population of immune cells suspended in the fluid media, wherein, the at least one porous scaffold coated with said ECM is creates a stationary niche having low shear forces that imitate the natural growth environment of the immune cells and allows expansion of the immune cells population that flow through the coated porous scaffold in large scale.
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公开(公告)号：US20240293471A1
公开(公告)日：2024-09-05
申请号：US18689276
申请日：2022-08-29
Applicant: PLURI BIOTECH LTD.
Inventor： Daniel ROTHENSTEIN , Yuval MATHEWS
CPC classification number: A61K35/50 , A61K9/0019 , A61P9/10 , C12N5/0605 , G01N33/66 , G01N33/6893 , G01N2333/805 , G01N2800/042
Abstract: Disclosed herein are methods and compositions comprising placental adherent stromal cells for treating peripheral ischemic disease, for example critical limb ischemia in specific patient subpopulations; and methods of selecting subjects having peripheral ischemic disease, for example critical limb ischemia, amenable for treatment with placental adherent stromal cells.
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公开(公告)号：US20240200009A1
公开(公告)日：2024-06-20
申请号：US18593869
申请日：2024-03-02
Applicant: PLURI BIOTECH LTD.
Inventor： Lior RAVIV , Shirley BACHAR , Dorina ROBERMAN
CPC classification number: C12M25/14 , C12M23/02 , C12M23/20 , C12M25/18 , C12N5/0634 , C12N2513/00
Abstract: This invention discloses a three-dimensional (3D) bioreactor for large scale expansion of immune cells and methods of use. The 3D bioreactor comprising at least one packed bed chamber comprising at least one porous scaffold; at least one porous scaffold coated with one or more extra cellular matrix protein (ECM); at least one container comprising a fluid media, the fluid media is configured to flow through said packed bed chamber with at least one porous coated scaffold; and at least one population of immune cells suspended in the fluid media, wherein, the at least one porous scaffold coated with said ECM is creates a stationary niche having low shear forces that imitate the natural growth environment of the immune cells and allows expansion of the immune cells population that flow through the coated porous scaffold in large scale.
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公开(公告)号：US20230357713A1
公开(公告)日：2023-11-09
申请号：US18207304
申请日：2023-06-08
Applicant: PLURI BIOTECH LTD.
Inventor： Lior RAVIV , Eran BEN ELIEZER
CPC classification number: C12N5/04 , C12M25/18 , C12M33/08 , C12M25/02 , C12M27/02 , C12M29/00 , C12M41/00
Abstract: This invention is directed to a method for three-dimensional cultivation of proliferating plant cells in a packed bed bioreactor, the bioreactor comprising at least one packed bed chamber configured to confine said proliferating plant cells within it such that the proliferating plant cells become a three-dimensional stationary biomass phase; and At least one container comprising a fluid media, the fluid media is configured to flow through said proliferating plant cells stationary biomass phase, wherein, the flow of the fluid media through the proliferating plant cells stationary biomass phase allows transfer of compounds from the fluid media into the cells and vice versa in low sheer forces within the at least one packed bed chamber thereby imitating natural growth environment of the proliferating plant cells within the 3D bioreactor.
