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1.发明公开公开(公告)号：US20240288419A1
公开(公告)日：2024-08-29
申请号：US18025103
申请日：2021-09-08
Applicant: CRYSTALSFIRST GMBH
Inventor： Gerhard KLEBE , Stefan MERKL , Serghei GLINCA , Kan FU
CPC classification number: G01N33/5306 , G01N33/5308 , C40B30/04
Abstract: Subject-matter of the present invention is an array comprising soaking solutions for soaking a biological macromolecular crystal. Further, the subject of the invention is a rule-based method of selecting specific soaking solution compositions having a specific composition comprising composite solute(s) and organic solvent(s). Additionally, the subjects matter of the invention are non-aqueous soaking solutions, the soaking solutions obtained by the method of the invention and a screening method for small molecules comprising molecular probes, fragments and drug-size molecules using the soaking solutions and the use of the soaking solutions in a screening method for small molecules on a macromolecular crystal.
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2.发明公开
公开(公告)号：US20230332333A1
公开(公告)日：2023-10-19
申请号：US18025100
申请日：2021-09-08
Applicant: CRYSTALSFIRST GMBH
Inventor： Gerhard KLEBE , Stefan MERKL , Serghei GLINCA , Kan FU
Abstract: Subject-matter of the present invention is an array comprising soaking solutions for soaking a biological macromolecular crystal. Further, the subject of the invention is a rule-based method of selecting specific soaking solution compositions having a specific composition comprising composite solute(s), water (w), crystallization solution (crs) and/or organic solvent(s). Additionally, the subjects matter of the invention the soaking solutions obtained by the method of the invention and a screening method for small molecules comprising molecular probes, fragments and drug-size molecules using the soaking solutions and the use of the soaking solutions in a screening method for small molecules on a macromolecular crystal.
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3.发明公开
公开(公告)号：US20230323565A1
公开(公告)日：2023-10-12
申请号：US18025107
申请日：2021-09-08
Applicant: CRYSTALSFIRST GMBH
Inventor： Gerhard KLEBE , Stefan MERKL , Serghei GLINCA , Kan FU
Abstract: Subject-matter of the present invention is an array comprising soaking solutions for soaking a biological macromolecular crystal. Further, the subject of the invention is a rule-based method of selecting specific soaking solution compositions having a specific composition comprising composite solute(s), water (w), crystallization solution (crs) and/or organic solvent(s). Additionally, the subjects matter of the invention the soaking solutions obtained by the method of the invention and a screening method for small molecules comprising molecular probes, fragments and drug-size molecules using the soaking solutions and the use of the soaking solutions in a screening method for small molecules on a macromolecular crystal.
