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191 条记录 (耗时 0.053 秒)

    Cardiovascular Prostheses
    4.
    发明申请
    Cardiovascular Prostheses 有权

    公开(公告)号：US20210316042A1

    公开(公告)日：2021-10-14

    申请号：US17358616

    申请日：2021-06-25

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61L27/36 ,  A61F2/06 ,  A61F2/00 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61K31/4418 ,  A61L27/38 ,  A61L27/50

    摘要： Biomaterial compositions for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include a plurality of particulate structures. The biomaterial compositions include poly(glycerol sebacate) (PGS) and an antifibrotic. The biomaterial compositions can also include poly(glycerol sebacate) acrylate (PGSA) and an antifibrotic. The biomaterial compositions can further include acellular extracellular matrix (ECM) derived from a mammalian tissue source, such as small intestine submucosa, cardiac tissue and placental tissue. The biomaterial compositions are adapted to modulate inflammation of damaged tissue and induce neovascularization, host cell proliferation, remodeling of damaged tissue, and regeneration of new tissue and tissue structures.

    Systems, Apparatus and Methods for Sealing Perivalvular Leaks
    5.
    发明申请
    Systems, Apparatus and Methods for Sealing Perivalvular Leaks 有权

    公开(公告)号：US20210228346A1

    公开(公告)日：2021-07-29

    申请号：US17231229

    申请日：2021-04-15

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G Matheny

    IPC分类号： A61F2/24

    摘要： A biocompatible and biodegradable construct comprising a base expandable member and an outer coating comprising poly(glycerol sebacate) (PGS), the base expandable member comprising acellular extracellular matrix (ECM) derived from a mammalian tissue source, the acellular ECM exhibiting a flexible, porous, expandable structure, which is adapted to expand upon exposure to and absorption of a bodily fluid, wherein the construct seals a perivalvular leak when disposed proximate thereto.

    Cardiovascular Prostheses
    6.
    发明申请
    Cardiovascular Prostheses 有权

    公开(公告)号：US20210196859A1

    公开(公告)日：2021-07-01

    申请号：US17178406

    申请日：2021-02-18

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61L27/36 ,  A61F2/06 ,  A61F2/00 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61K31/4418 ,  A61L27/38 ,  A61L27/50

    摘要： Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include a plurality of particulate structures. The particulate structures further include an acellular ECM core and an outer layer or coating comprising poly(glycerol sebacate) (PGS) and everolimus. When the particulate structures are delivered to the damaged cardiovascular tissue the outer layer is adapted to induce a first level of remodeling and suppress hyperplasia, and the acellular ECM is adapted to induce a second level of remodeling.

    Adaptable Prosthetic Tissue Valves
    7.
    发明申请
    Adaptable Prosthetic Tissue Valves 有权

    公开(公告)号：US20210169644A1

    公开(公告)日：2021-06-10

    申请号：US17181161

    申请日：2021-02-22

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G Matheny

    IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/54 ,  A61L27/38

    摘要： Prosthetic valves that include conical shaped base valve members having an annular engagement end, a closed distal end region that restricts fluid flow therethrough, and a plurality of elongated ribbon members, which transition from an open fluid flow configuration to a closed fluid flow configuration in response to expansion and contraction of the base valve member, and a support structure that is configured and adapted to exert retaining forces on the annular engagement ends of the base valve members, whereby the support structure (i) conforms to the shape of the annular engagement ends of the base valve members, (ii) securely positions the annular engagement ends of the base valve members adjacent to and, thereby, in contact with a valve annulus, whereby the annular engagement ends of the base valve members conform to the shape of the valve annulus, and (iii) the annular engagement ends of the base valve members adapt to at least one fluctuation in the configuration and/or dimension of the valve annulus, whereby the annular engagement ends of the base valve members maintain contact therewith.

    Prosthetic Tissue Valves
    9.
    发明申请
    Prosthetic Tissue Valves 审中-公开

    公开(公告)号：US20200069840A1

    公开(公告)日：2020-03-05

    申请号：US16440504

    申请日：2019-06-13

    申请人： CorMatrix Cardiovascular, Inc.

    发明人： Robert G. Matheny

    IPC分类号： A61L27/36 ,  A61F2/24 ,  A61L27/54 ,  A61L27/38

    摘要： A prosthetic valve comprising a conical shaped ribbon structure comprising an extracellular matrix (ECM) composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.