公开(公告)号：US20250019412A1

公开(公告)日：2025-01-16

申请号：US18895187

申请日：2024-09-24

Applicant: Alpine Immune Sciences, Inc.

Inventor： Stacey DILLON ,  Mark RIXON ,  Lawrence EVANS ,  Daniel William DEMONTE ,  Joseph L. KUIJPER ,  Stanford L. PENG

IPC: C07K14/705 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61K47/64 ,  A61P37/06 ,  C07K14/715

Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.

公开(公告)号：US20240279310A1

公开(公告)日：2024-08-22

申请号：US18289746

申请日：2022-05-06

Applicant: Alpine Immune Sciences, Inc.

Inventor： Stacey DILLON ,  Jing YANG ,  Stanford L. PENG

IPC: C07K14/705 ,  A61K9/00 ,  A61K38/00 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07K14/70578 ,  A61K9/0019 ,  A61P29/00 ,  A61P37/00 ,  A61K38/00 ,  C07K2319/30

Abstract: Provided herein are methods of treatment and uses involving an immunomodulatory TACI-Fc fusion protein that exhibits neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The provided TACI-Fc protein may include variant domains of Transmembrane Activator and CAML Interactor (TACI). The methods and uses provide therapeutic utility for a variety of immunological diseases, disorders or conditions, such as B cell-mediated diseases, disorder or conditions.

公开(公告)号：US20240218045A1

公开(公告)日：2024-07-04

申请号：US18186098

申请日：2023-03-17

Applicant: Alpine Immune Sciences, Inc.

Inventor： Stacey DILLON ,  Mark RIXON ,  Lawrence EVANS ,  Daniel William DEMONTE ,  Joseph L. KUIJPER ,  Stanford L. PENG

IPC: C07K14/705 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61K47/64 ,  A61P37/06 ,  C07K14/715

CPC classification number: C07K14/70578 ,  A61K38/1774 ,  A61K38/1793 ,  A61K47/6425 ,  A61P37/06 ,  C07K14/7151 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/31

Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.

公开(公告)号：US20240158463A1

公开(公告)日：2024-05-16

申请号：US18355539

申请日：2023-07-20

Applicant: Alpine Immune Sciences, Inc.

Inventor： Lawrence EVANS ,  Joseph L. KUIJPER ,  Ryan SWANSON

IPC: C07K14/705 ,  A61K35/17 ,  A61K47/65 ,  A61P19/02 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/00

CPC classification number: C07K14/70521 ,  A61K35/17 ,  A61K47/65 ,  A61P19/02 ,  C07K14/7051 ,  C12N5/0637 ,  C12N15/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30

Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：US20220242930A1

公开(公告)日：2022-08-04

申请号：US17707511

申请日：2022-03-29

Applicant: Alpine Immune Sciences, Inc.

Inventor： Ryan SWANSON ,  Michael KORNACKER

IPC: C07K14/705 ,  C07K14/715 ,  G01N33/564 ,  G01N33/574

Abstract: Provided are immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：US20220177587A1

公开(公告)日：2022-06-09

申请号：US17275646

申请日：2019-09-19

Applicant: Alpine Immune Sciences, Inc.

Inventor： Ryan SWANSON ,  Mark F. MAURER ,  Stanford L. PENG ,  Jing YANG ,  Kristine M. SWIDEREK

IPC: C07K16/28 ,  A61K31/282 ,  C07K14/705 ,  C12N15/62 ,  A61P35/00 ,  A61K45/06

Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of oncological conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：US20220153846A1

公开(公告)日：2022-05-19

申请号：US17591499

申请日：2022-02-02

Applicant: Alpine Immune Sciences, Inc.

Inventor： Ryan SWANSON ,  Michael KORNACKER

IPC: C07K16/28 ,  C07K14/705 ,  A61K47/65 ,  A61K47/68 ,  A61K47/64 ,  A61K35/768 ,  C12N15/62 ,  C12N15/85

Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：US20210363223A1

公开(公告)日：2021-11-25

申请号：US17346095

申请日：2021-06-11

Applicant: Alpine Immune Sciences, Inc.

Inventor： Stacey DILLON ,  Mark RIXON ,  Lawrence EVANS ,  Daniel William DEMONTE ,  Joseph L. KUIJPER ,  Stanford L. PENG

IPC: C07K14/705

Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.

公开(公告)号：US20210363219A1

公开(公告)日：2021-11-25

申请号：US17252233

申请日：2019-06-14

Applicant: Alpine Immune Sciences, Inc.

Inventor： Ryan SWANSON ,  Daniel William DEMONTE

IPC: C07K14/705 ,  C12N15/86 ,  C07K16/28

Abstract: Provided herein are immunomodulatory proteins comprising variant PD-1 polypeptides, nucleic acids encoding such proteins and engineered cells expressing such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.

公开(公告)号：US20210347897A1

公开(公告)日：2021-11-11

申请号：US17346107

申请日：2021-06-11

Applicant: Alpine Immune Sciences, Inc.

Inventor： Ryan SWANSON ,  Michael KORNACKER

IPC: C07K16/28 ,  C07K14/705 ,  A61K47/65 ,  A61K47/68 ,  A61K47/64 ,  A61K35/768 ,  C12N15/62 ,  C12N15/85

Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.