公开(公告)号：US11696957B2

公开(公告)日：2023-07-11

申请号：US16601333

申请日：2019-10-14

申请人： Sunstate Biosciences, LLC

发明人： Changjun Yu

IPC分类号： A61K31/136 ,  A61K47/68 ,  A61K47/64 ,  A61P35/00 ,  A61K31/337 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/498 ,  A61K31/519 ,  A61K31/704

CPC分类号： A61K47/6803 ,  A61K31/136 ,  A61K31/337 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/498 ,  A61K31/519 ,  A61K31/704 ,  A61K47/643 ,  A61K47/6809 ,  A61K47/6835 ,  A61P35/00

摘要： The invention provides compositions comprising a single protein having one or more molecules of a pharmaceutical agent tightly bound therein. The compositions are useful to decrease the toxicity and/or to widen the therapeutic window of the pharmaceutical agent. The invention also provides methods for preparing such a composition.

公开(公告)号：US20240287140A1

公开(公告)日：2024-08-29

申请号：US18415225

申请日：2024-01-17

申请人： Sunstate Biosciences, LLC

发明人： Changjun Yu

IPC分类号： C07K14/00 ,  C07K14/765

CPC分类号： C07K14/003 ,  C07K14/765 ,  C07K2319/60

摘要： The invention provides compositions comprising a single protein having one or more biopolymers or modified biopolymers for therapeutics and diagnostics tightly bound therein. The compositions are useful to enhance efficacy and water solution of biopolymers, decrease their toxicity and/or to widen therapeutic window of the biopolymers. The invention also provides methods for preparing such compositions.

公开(公告)号：US20240016948A1

公开(公告)日：2024-01-18

申请号：US18128828

申请日：2023-03-30

申请人： Sunstate Biosciences, LLC

发明人： Changjun Yu

IPC分类号： A61K47/68 ,  A61K47/64 ,  A61P35/00 ,  A61K31/136 ,  A61K31/337 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/498 ,  A61K31/519 ,  A61K31/704

CPC分类号： A61K47/6803 ,  A61K47/643 ,  A61K47/6809 ,  A61K47/6835 ,  A61P35/00 ,  A61K31/136 ,  A61K31/704 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/498 ,  A61K31/519 ,  A61K31/337

摘要： The invention provides compositions comprising a single protein having one or more molecules of a pharmaceutical agent tightly bound therein. The compositions are useful to decrease the toxicity and/or to widen the therapeutic window of the pharmaceutical agent. The invention also provides methods for preparing such a composition.