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公开(公告)号：US20240327343A1
公开(公告)日：2024-10-03
申请号：US18580519
申请日：2022-07-18
发明人： Guanjun ZHANG , Baokui SHUAI , Yuqing SHAN
IPC分类号： C07D207/08
CPC分类号： C07D207/08
摘要： The present invention discloses a preparation method of 3-(2, 2, 2-trifluoroethyl) pyrrolidine hydrochloride and(S)-3-(2, 2, 2-trifluoroethyl) pyrrolidine hydrochloride.
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公开(公告)号：US11814384B2
公开(公告)日：2023-11-14
申请号：US18164326
申请日：2023-02-03
发明人： Toufike Kanouni , Jason M. Cox , John Tyhonas , Robert S. Kania , Subhas J. Chakravorty , Young K. Chen
IPC分类号： C07D403/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D491/147
CPC分类号： C07D471/04 , C07D403/12 , C07D487/04 , C07D491/147 , C07D519/00
摘要： Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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公开(公告)号：US11780862B2
公开(公告)日：2023-10-10
申请号：US18175074
申请日：2023-02-27
发明人： Toufike Kanouni , Robert S. Kania , Jason M. Cox
IPC分类号： C07F9/58 , C07F9/6584 , C07F9/53
CPC分类号： C07F9/58 , C07F9/5325 , C07F9/6584
摘要： Provided herein are inhibitors of MEK kinase, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said MEK kinase inhibitory compounds for the treatment of disease.
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公开(公告)号：US20230174535A1
公开(公告)日：2023-06-08
申请号：US17605127
申请日：2020-05-14
发明人： Stephen W. KALDOR , John TYHONAS
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Provided herein are inhibitors of fibroblast growth factor receptor kinases, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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公开(公告)号：US11447493B2
公开(公告)日：2022-09-20
申请号：US17052162
申请日：2019-05-02
发明人： Toufike Kanouni , Lee Arnold , Stephen W. Kaldor , Eric A. Murphy
IPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D413/14 , A61K9/00 , A61K9/08 , A61K9/48 , C07D401/14
摘要： Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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公开(公告)号：US11407737B2
公开(公告)日：2022-08-09
申请号：US17477260
申请日：2021-09-16
发明人： Stephen W. Kaldor , Toufike Kanouni , John Tyhonas , Eric Murphy , Jason Cox , Robert Kania
IPC分类号： C07D401/14 , C07D413/14 , C07D401/12 , C07D471/08 , C07D265/30 , C07D417/14
摘要： Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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公开(公告)号：US20240067626A1
公开(公告)日：2024-02-29
申请号：US18341503
申请日：2023-06-26
IPC分类号： C07D401/12 , C07D215/22 , C07D405/14 , C07D471/04
CPC分类号： C07D401/12 , C07D215/22 , C07D405/14 , C07D471/04
摘要： Provided herein are inhibitors of MET receptor tyrosine kinase, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said MET kinase inhibitory compounds for the treatment of disease.
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公开(公告)号：US11753395B2
公开(公告)日：2023-09-12
申请号：US18066056
申请日：2022-12-14
IPC分类号： C07D401/12 , C07D405/14 , C07D471/04 , C07D215/22
CPC分类号： C07D401/12 , C07D215/22 , C07D405/14 , C07D471/04
摘要： Provided herein are inhibitors of MET receptor tyrosine kinase, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said MET kinase inhibitory compounds for the treatment of disease.
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公开(公告)号：US20230074545A1
公开(公告)日：2023-03-09
申请号：US17789484
申请日：2020-12-23
发明人： Eric A. MURPHY , John TYHONAS , Noelito TIMPLE , Toufike KANOUNI , Lee D. ARNOLD , Elisabeth GARDINER , Eric MARTIN
IPC分类号： A61K31/506 , A61P35/04 , A61P35/00 , C12Q1/6886
摘要： Provided herein are compositions and methods for the treatment of a triple-negative breast cancer, ovarian cancer and castration-resistant prostate cancer. Said compositions comprise CDK12/13 inhibitors.
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公开(公告)号：US11358958B2
公开(公告)日：2022-06-14
申请号：US17095672
申请日：2020-11-11
IPC分类号： C07D403/14 , C07D413/14 , C07D403/12 , C07D405/14 , C07D417/14 , C07D401/14
摘要： Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
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