公开(公告)号：US09823222B2

公开(公告)日：2017-11-21

申请号：US15471699

申请日：2017-03-28

Applicant: ADVANCED ANALYTICAL TECHNOLOGIES, INC.

Inventor： Ho-ming Pang ,  Wei Wei

IPC: G01N27/447 ,  G01N21/64

CPC classification number: G01N27/44791 ,  G01N21/6428 ,  G01N27/44721 ,  G01N27/44726

Abstract: A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.

公开(公告)号：US09518955B2

公开(公告)日：2016-12-13

申请号：US12634349

申请日：2009-12-09

Applicant: Pang Ho-ming ,  Wei Wei

Inventor： Pang Ho-ming ,  Wei Wei

IPC: G01N27/447 ,  G01N21/64

CPC classification number: G01N27/44791 ,  G01N21/6428 ,  G01N27/44721 ,  G01N27/44726

Abstract: The invention is a high sensitivity and high throughput capillary multiwavelength fluorescence detection system. The fluorescent detection system is configured to illuminate a relatively large volume of a single capillary or a plurality of capillaries, with a pixelated detection system capable of imaging an area of each capillary that differentiates the capillary walls, the space between the capillaries, and the internal liquid volume within the capillary. Only the desired pixels or image area are used for processing and generating an output signal.

Abstract translation: 本发明是高灵敏度和高通量的毛细管多波长荧光检测系统。 荧光检测系统被配置为照亮相对较大体积的单个毛细管或多个毛细管，其中像素化检测系统能够对每个毛细管的区域进行成像，以区分毛细管壁，毛细管之间的空间和内部 毛细管内的液体体积。 仅使用期望的像素或图像区域来处理和产生输出信号。

公开(公告)号：US08357281B2

公开(公告)日：2013-01-22

申请号：US12883475

申请日：2010-09-16

Applicant: Ho-Ming Pang ,  Wei Wei

Inventor： Ho-Ming Pang ,  Wei Wei

IPC: G01N27/00

CPC classification number: G01N27/44721

Abstract: Using multiple dichroics mirrors to split and redirect different wavelength regions of light in a multi-wavelength fluorescence detection system.

Abstract translation: 使用多个二向色镜在多波长荧光检测系统中分离和重定向不同波长的光区域。

公开(公告)号：US20110120869A1

公开(公告)日：2011-05-26

申请号：US13012446

申请日：2011-01-24

Applicant: HO-MING PANG

Inventor： HO-MING PANG

IPC: G01N27/447

CPC classification number: B01D57/02 ,  G01N27/44782

Abstract: The present invention provides a simple method to correct cross-talk, after the data have been generated. Adjacent signals are simply subtracted from the original observed signal with a repeating process. The data processing is stopped when a predefined condition is met. By this technique, cross-talk can be reduced from >5% to less than 0.1%. And as an additional advantage, this method provides a way to correct the cross-talk without the need to know which peaks are caused by the adjacent capillary signal.

Abstract translation: 本发明提供了在数据生成之后校正串扰的简单方法。 通过重复的过程简单地从原始观察信号中减去相邻的信号。 当满足预定义条件时，停止数据处理。 通过这种技术，串扰可以从> 5％降低到小于0.1％。 而且作为另外的优点，该方法提供了一种校正串扰的方法，而不需要知道相邻毛细管信号引起哪些峰。

公开(公告)号：US07901557B2

公开(公告)日：2011-03-08

申请号：US12426317

申请日：2009-04-20

Applicant: Ho-Ming Pang

Inventor： Ho-Ming Pang

IPC: G01N27/447

CPC classification number: B01D57/02 ,  G01N27/44773

Abstract: The present invention provides a simple method to correct cross-talk, after the data have been generated. Adjacent signals are simply subtracted from the original observed signal with a repeating process. The data processing is stopped when a predefined condition is met. By this technique, cross-talk can be reduced from >5% to less than 0.1%. And as an additional advantage, this method provides a way to correct the cross-talk without the need to know which peaks are caused by the adjacent capillary signal.

Abstract translation: 本发明提供了在数据生成之后校正串扰的简单方法。 通过重复的过程简单地从原始观察信号中减去相邻的信号。 当满足预定义条件时，停止数据处理。 通过这种技术，串扰可以从> 5％降低到小于0.1％。 而且作为另外的优点，该方法提供了一种校正串扰的方法，而不需要知道相邻毛细管信号引起哪些峰值。

公开(公告)号：US20100264028A1

公开(公告)日：2010-10-21

申请号：US12426317

申请日：2009-04-20

Applicant: HO-MING PANG

Inventor： HO-MING PANG

IPC: B01D57/02

CPC classification number: B01D57/02 ,  G01N27/44773

Abstract: The present invention provides a simple method to correct cross-talk, after the data have been generated. Adjacent signals are simply subtracted from the original observed signal with a repeating process. The data processing is stopped when a predefined condition is met. By this technique, cross-talk can be reduced from >5% to less than 0.1%. And as an additional advantage, this method provides a way to correct the cross-talk without the need to know which peaks are caused by the adjacent capillary signal.

Abstract translation: 本发明提供了在数据生成之后校正串扰的简单方法。 通过重复的过程简单地从原始观察信号中减去相邻的信号。 当满足预定义条件时，停止数据处理。 通过这种技术，串扰可以从> 5％降低到小于0.1％。 而且作为另外的优点，该方法提供了一种校正串扰的方法，而不需要知道相邻毛细管信号引起哪些峰。

公开(公告)号：US20100140505A1

公开(公告)日：2010-06-10

申请号：US12634349

申请日：2009-12-09

Applicant: Ho-ming Pang ,  Wei Wei

Inventor： Ho-ming Pang ,  Wei Wei

IPC: G01J1/58

CPC classification number: G01N27/44791 ,  G01N21/6428 ,  G01N27/44721 ,  G01N27/44726

Abstract: The invention includes a high sensitivity and high throughput capillary electrophoresis multiwavelength florescence detection system. The fluorescent detection system is configured to illuminate a relatively large volume of a single capillary or a plurality of capillaries, with a pixelated detection system capable of imaging an area of each capillary that differentiates the capillary walls, the space between the capillaries, and the internal liquid volume within the capillary. Only the desired pixels or image area are used for processing and generating an output signal.

Abstract translation: 本发明包括高灵敏度和高通量的毛细管电泳多波长荧光检测系统。 荧光检测系统被配置为照亮相对较大体积的单个毛细管或多个毛细管，其中像素化检测系统能够对每个毛细管的区域进行成像，以区分毛细管壁，毛细管之间的空间和内部 毛细管内的液体体积。 仅使用期望的像素或图像区域来处理和产生输出信号。

公开(公告)号：US07370819B2

公开(公告)日：2008-05-13

申请号：US11527152

申请日：2006-09-26

Applicant: Robert Czarnek

Inventor： Robert Czarnek

IPC: B02C19/00

CPC classification number: G01N1/286 ,  G01N2001/2866

Abstract: In a biological sample grinding device and method, a bearing having a plurality of rolling elements disposed between a pair of rings is disposed in a container in which a fluid having at least one biological sample particle therein is introduced. With the bearing immersed in the fluid having the biological sample particle therein, one ring of the bearing is rotated relative to the other ring thereof, whereupon the rolling elements roll between the pair of rings and, in response thereto, the biological sample particle is drawn by the fluid between the pair of rings where it is subject to being crushed or ground between at least one of the rolling elements and at least one of the rings. A baffle can be disposed in the container for inhibiting the rotation of the fluid and, hence, the introduction of air into the fluid.

Abstract translation: 在生物样品研磨装置和方法中，将具有设置在一对环之间的多个滚动元件的轴承设置在其中引入至少一个生物样品颗粒的流体的容器中。 当轴承浸入其中具有生物样品颗粒的流体中时，轴承的一个环相对于另一个环旋转，随后滚动元件在一对环之间滚动，并且响应于此，生物样品颗粒被拉伸 通过所述一对环之间的流体在其中在至少一个滚动元件和至少一个环之间被破碎或磨碎。 挡板可以设置在容器中，以阻止流体的旋转，从而将空气引入流体。

公开(公告)号：US09612204B2

公开(公告)日：2017-04-04

申请号：US15167990

申请日：2016-05-27

Applicant: ConocoPhillips Company ,  Advanced Analytical Technologies, Inc.

Inventor： Jay Edward Locklear ,  Thomas Baugh ,  Pierre Varineau ,  Wei Wei

IPC: G01N21/78 ,  G01N21/64 ,  G01N27/447 ,  G01N33/18 ,  G01N21/77 ,  C02F5/08 ,  G01N33/28

CPC classification number: G01N21/78 ,  C02F5/08 ,  C02F2103/10 ,  C02F2103/365 ,  C02F2209/003 ,  C02F2303/22 ,  G01N21/6428 ,  G01N21/643 ,  G01N27/44726 ,  G01N33/1833 ,  G01N33/2823 ,  G01N2021/7786

Abstract: A method for determining a concentration of a scale inhibitor in a water system that includes contacting a scale inhibitor with a dye in a capillary channel to form a complex effective to generate fluorescence; measuring a fluorescence signal generated by the complex; and, determining the concentration of the scale inhibitor based on the fluorescence signal.

公开(公告)号：US09140666B2

公开(公告)日：2015-09-22

申请号：US13470870

申请日：2012-05-14

Applicant: Bruce R. Boeke ,  Martin Chris Foster ,  Thomas J. Kurt ,  Scott Stueckradt

Inventor： Bruce R. Boeke ,  Martin Chris Foster ,  Thomas J. Kurt ,  Scott Stueckradt

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  G01N27/44743

Abstract: The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.

Abstract translation: 本发明是一种改进的多重毛细管电泳仪器或模块，其具有至少四个并且优选六个用户易于垂直堆叠的抽屉。 x-z平台将样品从用户可访问的抽屉移动到毛细管阵列进行分析。 计算机程序允许用户将毛细管电泳作业添加到对应于样品行或板的分析的队列中，而不停止或中断正在进行的运行。