OXIME-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AS ORL-1 MODULATORS
    86.
    发明申请
    OXIME-SUBSTITUTED QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AS ORL-1 MODULATORS 审中-公开
    作为ORL-1调节剂的OXIME取代的喹啉类型哌啶化合物

    公开(公告)号:US20150238485A1

    公开(公告)日:2015-08-27

    申请号:US14706641

    申请日:2015-05-07

    Abstract: The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound.

    Abstract translation: 本公开涉及肟取代的喹喔啉型哌啶化合物,例如式(I)的化合物及其药学上可接受的盐和溶剂合物,其中R1,R2,R3,R4,R20,R21,Q,Y1,Z ,A,B和a如本文所定义; 包含有效量的肟取代的喹喔啉哌啶化合物的组合物,以及治疗或预防诸如疼痛的病症的方法,包括向有需要的动物施用有效量的肟取代的喹喔啉型哌啶化合物 。

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